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GO:0030414 peptidase inhibitor activity

Term Information

ID GO:0030414
Name peptidase inhibitor activity
Ontology Molecular Function
Definition Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
GONUTS GO:0030414 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related protease inhibitor activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR008037
InterPro IPR008197
InterPro IPR008296
InterPro IPR016397
UniProtKB-KW Bait region
UniProtKB-KW Protease inhibitor

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0017114 wide-spectrum protease inhibitor activity REPLACEDBY GO:0030414
GO:0030415 carboxypeptidase A inhibitor activity REPLACEDBY GO:0030414

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030414:
Relationship To GO:0030414 Child Term Child Term Name
Is a GO:0004866 endopeptidase inhibitor activity
Is a GO:0060422 peptidyl-dipeptidase inhibitor activity

Protein Annotation

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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
Evidence
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Date
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0030414. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0030414 based on the entire annotation set Co-occurrence statistics for GO:0030414 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0010466 (negative regulation of peptidase activity)
2010-06-15 Added RELATION negatively regulates GO:0008233 (peptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0008233 (peptidase activity)
2010-06-14 Deleted RELATION part of GO:0010466 (negative regulation of peptidase activity)
2010-06-08 Added RELATION part of GO:0010466 (negative regulation of peptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0008233 (peptidase activity)
2010-05-19 Added RELATION is a GO:0061134 (peptidase regulator activity)
2009-06-11 Deleted DEFINITION Stops, prevents or reduces the activity of a peptidase, any enzyme catalyzes the hydrolysis peptide bonds.
2009-06-11 Added DEFINITION Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
2009-03-16 Deleted SYNONYM protease inhibitor activity
2009-03-16 Added SYNONYM protease inhibitor activity
2009-03-15 Added DEFINITION Stops, prevents or reduces the activity of a peptidase, any enzyme catalyzes the hydrolysis peptide bonds.
2009-03-15 Updated TERM peptidase inhibitor activity
2009-03-15 Deleted DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2009-03-15 Deleted SYNONYM peptidase inhibitor
2009-03-15 Added SYNONYM protease inhibitor activity
2009-02-25 Deleted RELATION negatively regulates GO:0008233 (peptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0008233 (peptidase activity)
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2008-04-01 Updated RELATION is a GO:0004857 (enzyme inhibitor activity)
2007-08-09 Added SYNONYM peptidase inhibitor
2007-08-09 Deleted SYNONYM peptidase inhibitor
2004-04-19 Added SYNONYM peptidase inhibitor
2004-04-16 Deleted SYNONYM peptidase inhibitor
2004-01-08 Updated DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2003-04-09 Updated DEFINITION Stops, prevents or reduces the activity of any enzyme that hydrolyzes peptide bonds.
2003-03-19 Updated TERM protease inhibitor activity
2002-11-27 Added DEFINITION Stops, prevents or decreases the activity of any enzyme that hydrolyzes peptide bonds.
2002-02-14 Added SYNONYM peptidase inhibitor
2001-11-14 Added TERM protease inhibitor

Term

Timestamp Action Category Detail
2009-03-15 Updated TERM peptidase inhibitor activity
2003-03-19 Updated TERM protease inhibitor activity
2001-11-14 Added TERM protease inhibitor

Definition/synonyms

Timestamp Action Category Detail
2009-06-11 Deleted DEFINITION Stops, prevents or reduces the activity of a peptidase, any enzyme catalyzes the hydrolysis peptide bonds.
2009-06-11 Added DEFINITION Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
2009-03-16 Deleted SYNONYM protease inhibitor activity
2009-03-16 Added SYNONYM protease inhibitor activity
2009-03-15 Added DEFINITION Stops, prevents or reduces the activity of a peptidase, any enzyme catalyzes the hydrolysis peptide bonds.
2009-03-15 Deleted DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2009-03-15 Deleted SYNONYM peptidase inhibitor
2009-03-15 Added SYNONYM protease inhibitor activity
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2007-08-09 Added SYNONYM peptidase inhibitor
2007-08-09 Deleted SYNONYM peptidase inhibitor
2004-04-19 Added SYNONYM peptidase inhibitor
2004-04-16 Deleted SYNONYM peptidase inhibitor
2004-01-08 Updated DEFINITION Stops, prevents or reduces the activity of a protease, any enzyme catalyzes the hydrolysis peptide bonds.
2003-04-09 Updated DEFINITION Stops, prevents or reduces the activity of any enzyme that hydrolyzes peptide bonds.
2002-11-27 Added DEFINITION Stops, prevents or decreases the activity of any enzyme that hydrolyzes peptide bonds.
2002-02-14 Added SYNONYM peptidase inhibitor

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0010466 (negative regulation of peptidase activity)
2010-06-15 Added RELATION negatively regulates GO:0008233 (peptidase activity)
2010-06-14 Deleted RELATION negatively regulates GO:0008233 (peptidase activity)
2010-06-14 Deleted RELATION part of GO:0010466 (negative regulation of peptidase activity)
2010-06-08 Added RELATION part of GO:0010466 (negative regulation of peptidase activity)
2010-06-08 Added RELATION negatively regulates GO:0008233 (peptidase activity)
2010-05-19 Added RELATION is a GO:0061134 (peptidase regulator activity)
2009-02-25 Deleted RELATION negatively regulates GO:0008233 (peptidase activity)
2009-02-22 Added RELATION negatively regulates GO:0008233 (peptidase activity)
2008-04-01 Updated RELATION is a GO:0004857 (enzyme inhibitor activity)
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