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GO:0030154 cell differentiation

The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.

Term Information

ID	GO:0030154
Name	cell differentiation
Ontology	Biological Process
Definition	The process whereby relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate.
Comment

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

	GO slim name	Count of all terms
	goslim_generic	127
	goslim_goa	62
	goslim_plant	102

Cross-references associated with this term:

Database	ID
INTERPRO	IPR011656
INTERPRO	IPR000800
INTERPRO	IPR015737
INTERPRO	IPR010660
Wikipedia	Cellular_differentiation
INTERPRO	IPR009800

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GTerm?id=termID&format=format

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.

GO:0008150 biological_process

GO:0032502 developmental process

GO:0009987 cellular process

GO:0048869 cellular developmental process

GO:0030154 cell differentiation

Relationship key

Code	Relationship
	part of
	is a
	regulates
	+ve regulates
	-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:

P	GO:0048468 cell development
I	GO:0048824 pigment cell precursor differentiation
I	GO:0060034 notochord cell differentiation
I	GO:0001649 osteoblast differentiation
I	GO:0048515 spermatid differentiation
I	GO:0030435 sporulation resulting in formation of a cellular spore
I	GO:0048756 sieve cell differentiation
I	GO:0014001 sclerenchyma cell differentiation
I	GO:0042692 muscle cell differentiation
I	GO:0009559 embryo sac central cell differentiation
I	GO:0009560 embryo sac egg cell differentiation
I	GO:0009563 synergid differentiation
I	GO:0030182 neuron differentiation
I	GO:0030855 epithelial cell differentiation
I	GO:0030099 myeloid cell differentiation
I	GO:0048759 vessel member cell differentiation
I	GO:0048760 parenchymal cell differentiation
I	GO:0048761 collenchyma cell differentiation
I	GO:0048762 mesenchymal cell differentiation
I	GO:0050931 pigment cell differentiation
I	GO:0031149 sorocarp stalk cell differentiation
I	GO:0014816 satellite cell differentiation
I	GO:0048235 pollen sperm cell differentiation
I	GO:0042675 compound eye cone cell differentiation
I	GO:0035051 cardiac cell differentiation
I	GO:0009913 epidermal cell differentiation
I	GO:0042386 hemocyte differentiation
I	GO:0045444 fat cell differentiation
I	GO:0070306 lens fiber cell differentiation
I	GO:0048657 tapetal cell differentiation
I	GO:0003309 pancreatic B cell differentiation
I	GO:0003310 pancreatic A cell differentiation
I	GO:0003311 pancreatic D cell differentiation
I	GO:0003312 pancreatic PP cell differentiation
I	GO:0048533 sporocyte differentiation
I	GO:0002268 follicular dendritic cell differentiation
I	GO:0001826 inner cell mass cell differentiation
I	GO:0001829 trophectodermal cell differentiation
I	GO:0002062 chondrocyte differentiation
I	GO:0001570 vasculogenesis
I	GO:0043158 heterocyst differentiation
I	GO:0001549 cumulus cell differentiation
I	GO:0009557 antipodal cell differentiation
I	GO:0002521 leukocyte differentiation
I	GO:0007514 garland cell differentiation
I	GO:0009994 oocyte differentiation
I	GO:0010001 glial cell differentiation
P	GO:0045165 cell fate commitment
I	GO:0001742 oenocyte differentiation
R	GO:0045595 regulation of cell differentiation
NR	GO:0045596 negative regulation of cell differentiation
PR	GO:0045597 positive regulation of cell differentiation
I	GO:0060014 granulosa cell differentiation
I	GO:0060126 somatotropin secreting cell differentiation
I	GO:0060127 prolactin secreting cell differentiation
I	GO:0060128 adrenocorticotropin hormone secreting cell differentiation
I	GO:0060129 thyroid stimulating hormone secreting cell differentiation
I	GO:0008583 mystery cell fate differentiation
I	GO:0010444 guard mother cell differentiation
I	GO:0060563 neuroepithelial cell differentiation
I	GO:0022036 rhombomere cell differentiation
I	GO:0021515 cell differentiation in spinal cord
I	GO:0021533 cell differentiation in hindbrain
I	GO:0033327 Leydig cell differentiation
I	GO:0060290 transdifferentiation
I	GO:0048888 neuromast mantle cell differentiation
I	GO:0048889 neuromast support cell differentiation
I	GO:0060479 lung cell differentiation
I	GO:0060019 radial glial cell differentiation
I	GO:0060531 neuroendocrine cell differentiation involved in prostate gland acinus development
I	GO:0022619 generative cell differentiation
I	GO:0022620 vegetative cell differentiation
I	GO:0090077 foam cell differentiation
I	GO:0060008 Sertoli cell differentiation
I	GO:0010480 microsporocyte differentiation
I	GO:0070365 hepatocyte differentiation
I	GO:0048333 mesodermal cell differentiation
I	GO:0075301 cell differentiation involved in spore germination
I	GO:0048863 stem cell differentiation
P	GO:0070315 G1 to G0 transition involved in cell differentiation
I	GO:0060217 hemangioblast cell differentiation
I	GO:0010668 ectodermal cell differentiation
I	GO:0060591 chondroblast differentiation
I	GO:0002244 hemopoietic progenitor cell differentiation
I	GO:0060689 cell differentiation involved in salivary gland development
I	GO:0060706 cell differentiation involved in embryonic placenta development
I	GO:0021889 olfactory bulb interneuron differentiation
I	GO:0021979 hypothalamus cell differentiation
I	GO:0060718 chorionic trophoblast cell differentiation

Relationship key

Code	Relationship
P	part of
I	is a

Protein Annotation

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Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.

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