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GO:0030060 L-malate dehydrogenase activity

Term Information

ID GO:0030060
Name L-malate dehydrogenase activity
Ontology Molecular Function
Definition Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
GONUTS GO:0030060 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact NAD-malic dehydrogenase activity
exact malic acid dehydrogenase activity
related MDH
exact (S)-malate:NAD+ oxidoreductase activity
exact L-malate-NAD+ oxidoreductase activity
exact malate (NAD) dehydrogenase activity
exact NAD-specific malate dehydrogenase activity
exact NAD-malate dehydrogenase activity
exact NAD-linked malate dehydrogenase activity
exact malic dehydrogenase activity
exact NAD-L-malate dehydrogenase activity
exact NAD-dependent malate dehydrogenase activity
exact NAD-dependent malic dehydrogenase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.1.1.37
InterPro IPR010097
InterPro IPR011274
InterPro IPR011275
InterPro IPR023958
MetaCyc MALATE-DEH-RXN
RHEA 21435

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0030060:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0030060. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0030060 based on the entire annotation set Co-occurrence statistics for GO:0030060 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:21435
2010-10-08 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2010-10-08 Added DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0016615 (malate dehydrogenase activity)
2007-11-08 Deleted SYNONYM NAD-L-malate dehydrogenase
2007-11-08 Added SYNONYM NAD-dependent malate dehydrogenase activity
2007-11-08 Added SYNONYM NAD-dependent malic dehydrogenase activity
2007-11-08 Added SYNONYM NAD-linked malate dehydrogenase activity
2007-11-08 Added SYNONYM NAD-malate dehydrogenase activity
2007-11-08 Added SYNONYM NAD-malic dehydrogenase activity
2007-11-08 Added SYNONYM NAD-specific malate dehydrogenase activity
2007-11-08 Added SYNONYM malate (NAD) dehydrogenase activity
2007-11-08 Added SYNONYM malic acid dehydrogenase activity
2007-11-08 Added SYNONYM (S)-malate:NAD+ oxidoreductase activity
2007-11-08 Added SYNONYM L-malate-NAD+ oxidoreductase activity
2007-11-08 Added SYNONYM MDH
2007-11-08 Added SYNONYM NAD-L-malate dehydrogenase activity
2007-09-06 Added SYNONYM malic dehydrogenase activity
2007-09-06 Deleted SYNONYM malic dehydrogenase
2007-08-09 Added SYNONYM NAD-L-malate dehydrogenase
2007-08-09 Added SYNONYM malic dehydrogenase
2007-08-09 Deleted SYNONYM NAD-L-malate dehydrogenase
2007-08-09 Deleted SYNONYM malic dehydrogenase
2004-04-19 Added SYNONYM NAD-L-malate dehydrogenase
2004-04-19 Added SYNONYM malic dehydrogenase
2004-04-16 Deleted SYNONYM NAD-L-malate dehydrogenase
2004-04-16 Deleted SYNONYM malic dehydrogenase
2003-10-27 Added SYNONYM malic dehydrogenase
2003-10-27 Added SYNONYM NAD-L-malate dehydrogenase
2003-10-27 Added XREF MetaCyc:MALATE-DEH-RXN
2003-08-21 Deleted SYNONYM malic dehydrogenase
2003-08-21 Deleted SYNONYM NAD-L-malate dehydrogenase
2003-03-19 Updated TERM L-malate dehydrogenase activity
2003-03-19 Deleted SYNONYM malate dehydrogenase 1
2002-12-06 Added SYNONYM malic dehydrogenase
2002-11-27 Updated DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2002-10-16 Updated TERM L-malate dehydrogenase
2002-10-16 Added SYNONYM NAD-L-malate dehydrogenase
2002-10-16 Added SYNONYM malate dehydrogenase 1
2001-08-06 Added DEFINITION The catalysis of the interconversion of malate and NAD to/from oxaloacetate and NADH.
2001-06-21 Added XREF EC:1.1.1.37
2001-06-21 Added TERM malate dehydrogenase 1

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM L-malate dehydrogenase activity
2002-10-16 Updated TERM L-malate dehydrogenase
2001-06-21 Added TERM malate dehydrogenase 1

Definition/synonyms

Timestamp Action Category Detail
2010-10-08 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2010-10-08 Added DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+.
2008-05-13 Added DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2007-11-08 Deleted SYNONYM NAD-L-malate dehydrogenase
2007-11-08 Added SYNONYM NAD-dependent malate dehydrogenase activity
2007-11-08 Added SYNONYM NAD-dependent malic dehydrogenase activity
2007-11-08 Added SYNONYM NAD-linked malate dehydrogenase activity
2007-11-08 Added SYNONYM NAD-malate dehydrogenase activity
2007-11-08 Added SYNONYM NAD-malic dehydrogenase activity
2007-11-08 Added SYNONYM NAD-specific malate dehydrogenase activity
2007-11-08 Added SYNONYM malate (NAD) dehydrogenase activity
2007-11-08 Added SYNONYM malic acid dehydrogenase activity
2007-11-08 Added SYNONYM (S)-malate:NAD+ oxidoreductase activity
2007-11-08 Added SYNONYM L-malate-NAD+ oxidoreductase activity
2007-11-08 Added SYNONYM MDH
2007-11-08 Added SYNONYM NAD-L-malate dehydrogenase activity
2007-09-06 Added SYNONYM malic dehydrogenase activity
2007-09-06 Deleted SYNONYM malic dehydrogenase
2007-08-09 Added SYNONYM NAD-L-malate dehydrogenase
2007-08-09 Added SYNONYM malic dehydrogenase
2007-08-09 Deleted SYNONYM NAD-L-malate dehydrogenase
2007-08-09 Deleted SYNONYM malic dehydrogenase
2004-04-19 Added SYNONYM NAD-L-malate dehydrogenase
2004-04-19 Added SYNONYM malic dehydrogenase
2004-04-16 Deleted SYNONYM NAD-L-malate dehydrogenase
2004-04-16 Deleted SYNONYM malic dehydrogenase
2003-10-27 Added SYNONYM malic dehydrogenase
2003-10-27 Added SYNONYM NAD-L-malate dehydrogenase
2003-08-21 Deleted SYNONYM malic dehydrogenase
2003-08-21 Deleted SYNONYM NAD-L-malate dehydrogenase
2003-03-19 Deleted SYNONYM malate dehydrogenase 1
2002-12-06 Added SYNONYM malic dehydrogenase
2002-11-27 Updated DEFINITION Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+. Also oxidizes some other 2-hydroxydicarboxylic acids.
2002-10-16 Added SYNONYM NAD-L-malate dehydrogenase
2002-10-16 Added SYNONYM malate dehydrogenase 1
2001-08-06 Added DEFINITION The catalysis of the interconversion of malate and NAD to/from oxaloacetate and NADH.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
2008-04-01 Updated RELATION is a GO:0016615 (malate dehydrogenase activity)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:21435
2003-10-27 Added XREF MetaCyc:MALATE-DEH-RXN
2001-06-21 Added XREF EC:1.1.1.37
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