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GO:0007165 signal transduction

Term Information

ID GO:0007165
Name signal transduction
Ontology Biological Process
Definition The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Comment Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
Secondary IDs GO:0023033
GONUTS GO:0007165 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related signalling pathway
narrow signalling cascade
related signaling pathway
narrow signaling cascade

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_candida89
goslim_generic149
goslim_plant100
goslim_aspergillus85

Cross-references

Database ID
InterPro IPR000009
InterPro IPR000014
InterPro IPR000065
InterPro IPR000157
InterPro IPR000159
InterPro IPR000198
InterPro IPR000239
InterPro IPR000329
InterPro IPR000488
InterPro IPR000698
InterPro IPR001217
InterPro IPR001573
InterPro IPR001690
InterPro IPR001711
InterPro IPR002041
InterPro IPR002073
InterPro IPR002211
InterPro IPR002545
InterPro IPR002554
InterPro IPR003116
InterPro IPR003122
InterPro IPR003660
InterPro IPR003661
InterPro IPR004041
InterPro IPR004075
InterPro IPR004089
InterPro IPR004090
InterPro IPR008063
InterPro IPR008064
InterPro IPR008112
InterPro IPR008359
InterPro IPR008466
InterPro IPR008595
InterPro IPR008936
InterPro IPR009082
InterPro IPR009103
InterPro IPR009109
InterPro IPR009471
InterPro IPR010682
InterPro IPR011025
InterPro IPR011072
InterPro IPR011524
InterPro IPR012227
InterPro IPR012290
InterPro IPR012316
InterPro IPR012345
InterPro IPR013799
InterPro IPR013800
InterPro IPR013801
InterPro IPR014285
InterPro IPR014752
InterPro IPR014753
InterPro IPR015123
InterPro IPR015988
InterPro IPR016237
InterPro IPR016238
InterPro IPR016279
InterPro IPR016359
InterPro IPR017421
InterPro IPR017424
InterPro IPR017428
InterPro IPR018451
InterPro IPR019577
InterPro IPR020416
InterPro IPR020849
InterPro IPR026109
InterPro IPR026155
InterPro IPR026830
InterPro IPR026984
InterPro IPR027130
InterPro IPR027136
InterPro IPR027138
InterPro IPR027139
InterPro IPR028380
InterPro IPR028381
InterPro IPR028387
InterPro IPR028400
InterPro IPR028745
InterPro IPR028849
InterPro IPR029515
InterPro IPR029534
InterPro IPR029535
InterPro IPR029586
InterPro IPR029593
InterPro IPR029797
InterPro IPR029870
InterPro IPR030035
InterPro IPR030036
InterPro IPR030055
InterPro IPR030061
UniProtKB-KW Transducer
Wikipedia Signal_transduction

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0005013 neurotrophin TRK receptor activity CONSIDER GO:0007165
GO:0005014 neurotrophin TRKA receptor activity CONSIDER GO:0007165
GO:0005015 neurotrophin TRKB receptor activity CONSIDER GO:0007165
GO:0005016 neurotrophin TRKC receptor activity CONSIDER GO:0007165
GO:0023005 signal initiation by neurotransmitter CONSIDER GO:0007165
GO:0023036 initiation of signal transduction CONSIDER GO:0007165
GO:0023038 signal initiation by diffusible mediator CONSIDER GO:0007165
GO:0023047 signal initiation by chemical mediator CONSIDER GO:0007165
GO:0023048 signal initiation by lipid mediator CONSIDER GO:0007165
GO:0023049 signal initiation by protein/peptide mediator CONSIDER GO:0007165
GO:0023053 signal initiation by mechanical effect CONSIDER GO:0007165
GO:0023054 signal initiation by stretch effect CONSIDER GO:0007165

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0007165:
Relationship To GO:0007165 Child Term Child Term Name
Is a GO:0001402 signal transduction involved in filamentous growth
Part of GO:0004871 signal transducer activity
Regulates GO:0009966 regulation of signal transduction
Positively regulates GO:0009967 positive regulation of signal transduction
Negatively regulates GO:0009968 negative regulation of signal transduction
Part of GO:0048018 receptor agonist activity
Is a GO:0097411 hypoxia-inducible factor-1alpha signaling pathway
Is a GO:0035556 intracellular signal transduction
Is a GO:0060863 regulation of floral organ abscission by signal transduction
Is a GO:0007602 phototransduction
Is a GO:0023041 neuronal signal transduction
Is a GO:0032005 signal transduction involved in conjugation with cellular fusion
Is a GO:0060395 SMAD protein signal transduction
Is a GO:0097190 apoptotic signaling pathway
Is a GO:0090520 sphingolipid mediated signaling pathway
Is a GO:0038183 bile acid signaling pathway
Is a GO:0038034 signal transduction in absence of ligand
Is a GO:0002764 immune response-regulating signaling pathway
Is a GO:0006984 ER-nucleus signaling pathway
Is a GO:0007166 cell surface receptor signaling pathway
Is a GO:0007231 osmosensory signaling pathway
Is a GO:0009755 hormone-mediated signaling pathway
Is a GO:0009756 carbohydrate mediated signaling
Is a GO:0009863 salicylic acid mediated signaling pathway
Is a GO:0009870 defense response signaling pathway, resistance gene-dependent
Is a GO:0010017 red or far-red light signaling pathway
Is a GO:0010019 chloroplast-nucleus signaling pathway
Is a GO:0010204 defense response signaling pathway, resistance gene-independent
Is a GO:0010850 regulation of blood pressure by chemoreceptor signaling pathway
Is a GO:0023014 signal transduction by phosphorylation
Is a GO:0023019 signal transduction involved in regulation of gene expression
Is a GO:0023045 signal transduction by conformational transition
Is a GO:0030522 intracellular receptor signaling pathway
Is a GO:0031930 mitochondria-nucleus signaling pathway
Is a GO:0055095 lipoprotein particle mediated signaling
Is a GO:0071588 hydrogen peroxide mediated signaling pathway
Is a GO:1902420 signal transduction involved in Dma1-dependent checkpoint
Is a GO:0097527 necroptotic signaling pathway

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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ID Mapping

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0007165. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0007165 based on the entire annotation set Co-occurrence statistics for GO:0007165 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_metagenomics
2012-09-29 Deleted RELATION part of GO:0023052 (signaling)
2012-09-29 Added RELATION part of GO:0044700 (single organism signaling)
2012-02-17 Added SLIM goslim_metagenomics
2011-11-26 Deleted DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-11-26 Added DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-11-05 Added SLIM goslim_aspergillus
2011-08-21 Added RELATION part of GO:0007154 (cell communication)
2011-08-14 Deleted SLIM goslim_yeast
2011-02-23 Deleted DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream process,e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-02-23 Added DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-02-18 Deleted DEFINITION The process whereby a signal is passed across a cell to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal and ends with regulation of a downstream process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-02-18 Added DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream process,e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-01-30 Added RELATION is a GO:0051716 (cellular response to stimulus)
2011-01-30 Deleted RELATION part of GO:0051716 (cellular response to stimulus)
2011-01-16 Deleted DEFINITION The process in which a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2011-01-16 Added DEFINITION The process whereby a signal is passed across a cell to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal and ends with regulation of a downstream process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-01-16 Deleted SYNONYM signalling cascade
2011-01-16 Added SYNONYM signalling cascade
2011-01-16 Added SYNONYM signalling pathway
2011-01-16 Added SYNONYM signaling pathway
2011-01-16 Added SYNONYM signaling cascade
2011-01-16 Deleted SYNONYM signaling cascade
2011-01-16 Added RELATION part of GO:0051716 (cellular response to stimulus)
2011-01-16 Added RELATION part of GO:0023052 (signaling)
2011-01-16 Deleted RELATION part of GO:0023060 (signal transmission)
2011-01-16 Added SECONDARY GO:0023033 (signaling pathway)
2010-12-17 Deleted DEFINITION The process whereby a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2010-12-17 Added DEFINITION The process in which a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2010-11-07 Deleted DEFINITION The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.
2010-11-07 Added DEFINITION The process whereby a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2010-10-11 Added RELATION part of GO:0023060 (signal transmission)
2010-10-11 Deleted RELATION is a GO:0023060 (signal transmission)
2010-09-12 Deleted SLIM goslim_pombe
2010-02-20 Added RELATION is a GO:0023060 (signal transmission)
2010-02-20 Deleted RELATION is a GO:0007154 (cell communication)
2010-02-20 Deleted SYNONYM signalling
2010-02-20 Deleted SYNONYM signaling
2010-02-20 Deleted DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2010-02-20 Added DEFINITION The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.
2009-05-11 Added SLIM goslim_pombe
2009-03-02 Added XREF Wikipedia:Signal_transduction
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
2008-06-07 Added RELATION is a GO:0050794 (regulation of cellular process)
2008-05-13 Added DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2008-05-12 Deleted DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2008-04-18 Added SYNONYM signaling cascade
2008-04-18 Added SYNONYM signalling cascade
2008-04-01 Updated RELATION is a GO:0007154 (cell communication)
2007-08-09 Added SYNONYM signaling
2007-08-09 Added SYNONYM signalling
2007-08-09 Deleted SYNONYM signaling
2007-08-09 Deleted SYNONYM signalling
2007-04-21 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM activation of MAPK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-01-26 Added SYNONYM signaling
2007-01-26 Added SYNONYM signalling
2007-01-18 Deleted SYNONYM MAPKKK cascade during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM MAPKKK cascade during sporulation (sensu the Saccharomyces research community)
2007-01-18 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM activation of MAPK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2007-01-18 Deleted SYNONYM activation of MAPK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM activation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-18 Deleted SYNONYM activation of MAPKK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM activation of MAPKK during sporulation (sensu the Saccharomyces research community)
2007-01-18 Deleted SYNONYM activation of MAPKKK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM activation of MAPKKK during sporulation (sensu the Saccharomyces research community)
2007-01-18 Deleted SYNONYM inactivation of MAPK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM inactivation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM MAPKKK cascade during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM MAPKKK cascade during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM activation of MAPK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM activation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM activation of MAPKK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM activation of MAPKK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM activation of MAPKKK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM activation of MAPKKK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM inactivation of MAPK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM inactivation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM activation of MAPK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2005-10-28 Deleted SYNONYM neurotrophin TRK receptor activity
2005-10-28 Deleted SYNONYM neurotrophin TRKA receptor activity
2005-10-28 Deleted SYNONYM neurotrophin TRKB receptor activity
2005-10-28 Deleted SYNONYM neurotrophin TRKC receptor activity
2005-10-28 Deleted SYNONYM nuclear translocation of MAPK during sporulation (sensu Fungi)
2005-10-28 Deleted SYNONYM nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM activation of MAPK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM neurotrophin TRK receptor activity
2005-08-10 Added SYNONYM neurotrophin TRKA receptor activity
2005-08-10 Added SYNONYM neurotrophin TRKB receptor activity
2005-08-10 Added SYNONYM neurotrophin TRKC receptor activity
2005-08-10 Added SYNONYM nuclear translocation of MAPK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
2004-07-24 Updated DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2004-05-02 Updated DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the cell's functioning.
2002-11-27 Added DEFINITION Relaying of a signal by conversion from one physical or chemical form to another. In cell biology, the process by which a cell converts an extracellular signal into a response.
2002-02-06 Updated TERM signal transduction
2001-04-03 Updated TERM signal transduction
2001-03-30 Added TERM signal transduction

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM signal transduction
2001-04-03 Updated TERM signal transduction
2001-03-30 Added TERM signal transduction

Definition/synonyms

Timestamp Action Category Detail
2011-11-26 Deleted DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-11-26 Added DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-02-23 Deleted DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream process,e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-02-23 Added DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-02-18 Deleted DEFINITION The process whereby a signal is passed across a cell to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal and ends with regulation of a downstream process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-02-18 Added DEFINITION The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream process,e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-01-16 Deleted DEFINITION The process in which a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2011-01-16 Added DEFINITION The process whereby a signal is passed across a cell to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal and ends with regulation of a downstream process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2011-01-16 Deleted SYNONYM signalling cascade
2011-01-16 Added SYNONYM signalling cascade
2011-01-16 Added SYNONYM signalling pathway
2011-01-16 Added SYNONYM signaling pathway
2011-01-16 Added SYNONYM signaling cascade
2011-01-16 Deleted SYNONYM signaling cascade
2010-12-17 Deleted DEFINITION The process whereby a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2010-12-17 Added DEFINITION The process in which a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2010-11-07 Deleted DEFINITION The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.
2010-11-07 Added DEFINITION The process whereby a signal is converted into a form where it can ultimately trigger a change in the state or activity of a cell. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2010-02-20 Deleted SYNONYM signalling
2010-02-20 Deleted SYNONYM signaling
2010-02-20 Deleted DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2010-02-20 Added DEFINITION The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell.
2008-05-13 Added DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2008-05-12 Deleted DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2008-04-18 Added SYNONYM signaling cascade
2008-04-18 Added SYNONYM signalling cascade
2007-08-09 Added SYNONYM signaling
2007-08-09 Added SYNONYM signalling
2007-08-09 Deleted SYNONYM signaling
2007-08-09 Deleted SYNONYM signalling
2007-04-21 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM activation of MAPK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2007-04-21 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2007-04-21 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-01-26 Added SYNONYM signaling
2007-01-26 Added SYNONYM signalling
2007-01-18 Deleted SYNONYM MAPKKK cascade during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM MAPKKK cascade during sporulation (sensu the Saccharomyces research community)
2007-01-18 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM activation of MAPK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2007-01-18 Added SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2007-01-18 Added SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2007-01-18 Deleted SYNONYM activation of MAPK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM activation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-18 Deleted SYNONYM activation of MAPKK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM activation of MAPKK during sporulation (sensu the Saccharomyces research community)
2007-01-18 Deleted SYNONYM activation of MAPKKK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM activation of MAPKKK during sporulation (sensu the Saccharomyces research community)
2007-01-18 Deleted SYNONYM inactivation of MAPK during sporulation (sensu the Fungi research community)
2007-01-18 Deleted SYNONYM inactivation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM MAPKKK cascade during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM MAPKKK cascade during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM activation of MAPK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM activation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM activation of MAPKK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM activation of MAPKK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM activation of MAPKKK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM activation of MAPKKK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Added SYNONYM inactivation of MAPK during sporulation (sensu the Fungi research community)
2007-01-15 Added SYNONYM inactivation of MAPK during sporulation (sensu the Saccharomyces research community)
2007-01-15 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM activation of MAPK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2007-01-15 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2007-01-15 Deleted SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2005-10-28 Deleted SYNONYM neurotrophin TRK receptor activity
2005-10-28 Deleted SYNONYM neurotrophin TRKA receptor activity
2005-10-28 Deleted SYNONYM neurotrophin TRKB receptor activity
2005-10-28 Deleted SYNONYM neurotrophin TRKC receptor activity
2005-10-28 Deleted SYNONYM nuclear translocation of MAPK during sporulation (sensu Fungi)
2005-10-28 Deleted SYNONYM nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM MAPKKK cascade during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM MAPKKK cascade during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM activation of MAPK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM activation of MAPK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM activation of MAPKK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM activation of MAPKK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM activation of MAPKKK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM activation of MAPKKK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM inactivation of MAPK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM inactivation of MAPK during sporulation (sensu Saccharomyces)
2005-08-10 Added SYNONYM neurotrophin TRK receptor activity
2005-08-10 Added SYNONYM neurotrophin TRKA receptor activity
2005-08-10 Added SYNONYM neurotrophin TRKB receptor activity
2005-08-10 Added SYNONYM neurotrophin TRKC receptor activity
2005-08-10 Added SYNONYM nuclear translocation of MAPK during sporulation (sensu Fungi)
2005-08-10 Added SYNONYM nuclear translocation of MAPK during sporulation (sensu Saccharomyces)
2004-07-24 Updated DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the functioning of the cell.
2004-05-02 Updated DEFINITION The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately effecting a change in the cell's functioning.
2002-11-27 Added DEFINITION Relaying of a signal by conversion from one physical or chemical form to another. In cell biology, the process by which a cell converts an extracellular signal into a response.

Relationships

Timestamp Action Category Detail
2012-09-29 Deleted RELATION part of GO:0023052 (signaling)
2012-09-29 Added RELATION part of GO:0044700 (single organism signaling)
2011-08-21 Added RELATION part of GO:0007154 (cell communication)
2011-01-30 Added RELATION is a GO:0051716 (cellular response to stimulus)
2011-01-30 Deleted RELATION part of GO:0051716 (cellular response to stimulus)
2011-01-16 Added RELATION part of GO:0051716 (cellular response to stimulus)
2011-01-16 Added RELATION part of GO:0023052 (signaling)
2011-01-16 Deleted RELATION part of GO:0023060 (signal transmission)
2010-10-11 Added RELATION part of GO:0023060 (signal transmission)
2010-10-11 Deleted RELATION is a GO:0023060 (signal transmission)
2010-02-20 Added RELATION is a GO:0023060 (signal transmission)
2010-02-20 Deleted RELATION is a GO:0007154 (cell communication)
2008-06-07 Added RELATION is a GO:0050794 (regulation of cellular process)
2008-04-01 Updated RELATION is a GO:0007154 (cell communication)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Signal_transduction

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2011-11-05 Added SLIM goslim_aspergillus
2011-08-14 Deleted SLIM goslim_yeast
2011-01-16 Added SECONDARY GO:0023033 (signaling pathway)
2010-09-12 Deleted SLIM goslim_pombe
2009-05-11 Added SLIM goslim_pombe
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
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