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GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex

Term Information

ID GO:0019907
Name cyclin-dependent protein kinase activating kinase holoenzyme complex
Ontology Cellular Component
Definition A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
PMID:8752210
GONUTS GO:0019907 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact CAK complex
exact CDK-activating kinase complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
GOTAX:0000059 GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct cak_human Cyclin-dependent protein kinase-activating kinase complex

Cross-references

Database ID
IntAct EBI-1246076
IntAct EBI-9868598

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019907:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0019907. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0019907 based on the entire annotation set Co-occurrence statistics for GO:0019907 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2015-06-25 Deleted RELATION is a GO:0044428 (nuclear part)
2015-06-18 Added RELATION capable of GO:0019912 (cyclin-dependent protein kinase activating kinase activity)
2015-06-18 Added RELATION capable of part of GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
2015-06-18 Added RELATION capable of GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
2015-06-18 Added RELATION capable of part of GO:0006368 (transcription elongation from RNA polymerase II promoter)
2015-06-18 Added RELATION capable of GO:0005524 (ATP binding)
2015-06-18 Added RELATION capable of part of GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
2015-06-18 Added RELATION capable of part of GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
2015-06-18 Added RELATION capable of part of GO:0070816 (phosphorylation of RNA polymerase II C-terminal domain)
2015-06-18 Added RELATION capable of part of GO:0060261 (positive regulation of transcription initiation from RNA polymerase II promoter)
2014-12-04 Added RELATION is a GO:0032806 (carboxy-terminal domain protein kinase complex)
2014-11-28 Added RELATION is a GO:0019908 (nuclear cyclin-dependent protein kinase holoenzyme complex)
2014-11-28 Deleted RELATION is a GO:1902911 (protein kinase complex)
2014-11-28 Added XREF IntAct:EBI-9868598
2014-11-28 Added XREF IntAct:EBI-1246076
2014-11-28 Added RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2014-11-28 Added DEFINITION A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
2014-11-28 Deleted DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2014-04-21 Added RELATION is a GO:1902911 (protein kinase complex)
2014-04-21 Deleted RELATION is a GO:1990234 (transferase complex)
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2008-05-13 Added DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2008-05-12 Deleted DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2008-04-01 Updated RELATION is a GO:0044428 (nuclear part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2007-08-09 Added SYNONYM CAK complex
2007-08-09 Added SYNONYM CDK-activating kinase complex
2007-08-09 Deleted SYNONYM CAK complex
2007-08-09 Deleted SYNONYM CDK-activating kinase complex
2007-05-27 Added DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2007-05-19 Added SYNONYM CDK-activating kinase complex
2007-05-19 Added SYNONYM CAK complex
2002-11-28 Updated TERM cyclin-dependent protein kinase activating kinase holoenzyme complex
2002-01-08 Added TERM cyclin-dependent protein kinase activating kinase holoenzyme

Term

Timestamp Action Category Detail
2002-11-28 Updated TERM cyclin-dependent protein kinase activating kinase holoenzyme complex
2002-01-08 Added TERM cyclin-dependent protein kinase activating kinase holoenzyme

Definition/synonyms

Timestamp Action Category Detail
2014-11-28 Added DEFINITION A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH.
2014-11-28 Deleted DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2008-05-13 Added DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2008-05-12 Deleted DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2007-08-09 Added SYNONYM CAK complex
2007-08-09 Added SYNONYM CDK-activating kinase complex
2007-08-09 Deleted SYNONYM CAK complex
2007-08-09 Deleted SYNONYM CDK-activating kinase complex
2007-05-27 Added DEFINITION A protein complex that phosphorylates cyclin-dependent kinases such as Cdc2 on Thr161 (or an equivalent residue); contains a catalytic subunit and a regulatory subunit, and some examples also include an assembly factor.
2007-05-19 Added SYNONYM CDK-activating kinase complex
2007-05-19 Added SYNONYM CAK complex

Relationships

Timestamp Action Category Detail
2015-06-25 Deleted RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2015-06-25 Deleted RELATION is a GO:0044428 (nuclear part)
2015-06-18 Added RELATION capable of GO:0019912 (cyclin-dependent protein kinase activating kinase activity)
2015-06-18 Added RELATION capable of part of GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
2015-06-18 Added RELATION capable of GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
2015-06-18 Added RELATION capable of part of GO:0006368 (transcription elongation from RNA polymerase II promoter)
2015-06-18 Added RELATION capable of GO:0005524 (ATP binding)
2015-06-18 Added RELATION capable of part of GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
2015-06-18 Added RELATION capable of part of GO:2000045 (regulation of G1/S transition of mitotic cell cycle)
2015-06-18 Added RELATION capable of part of GO:0070816 (phosphorylation of RNA polymerase II C-terminal domain)
2015-06-18 Added RELATION capable of part of GO:0060261 (positive regulation of transcription initiation from RNA polymerase II promoter)
2014-12-04 Added RELATION is a GO:0032806 (carboxy-terminal domain protein kinase complex)
2014-11-28 Added RELATION is a GO:0019908 (nuclear cyclin-dependent protein kinase holoenzyme complex)
2014-11-28 Deleted RELATION is a GO:1902911 (protein kinase complex)
2014-11-28 Added RELATION is a GO:1902554 (serine/threonine protein kinase complex)
2014-04-21 Added RELATION is a GO:1902911 (protein kinase complex)
2014-04-21 Deleted RELATION is a GO:1990234 (transferase complex)
2013-11-28 Added RELATION is a GO:1990234 (transferase complex)
2013-11-28 Deleted RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Added RELATION is a GO:1902494 (catalytic complex)
2013-11-15 Deleted RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044428 (nuclear part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)

Cross-references

Timestamp Action Category Detail
2014-11-28 Added XREF IntAct:EBI-9868598
2014-11-28 Added XREF IntAct:EBI-1246076
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