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GO:0019643 reductive tricarboxylic acid cycle

Term Information

ID GO:0019643
Name reductive tricarboxylic acid cycle
Ontology Biological Process
Definition A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
PMID:15838028
Secondary IDs GO:0019644
GONUTS GO:0019643 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact reductive Kreb's cycle
exact reductive TCA cycle
exact reductive carboxylate cycle
exact reductive carboxylic acid cycle
exact reductive citric acid pathway

Cross-references

Database ID
MetaCyc P23-PWY
MetaCyc REDCITCYC

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019643:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0019643. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0019643 based on the entire annotation set Co-occurrence statistics for GO:0019643 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
2008-05-12 Deleted DEFINITION A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
2008-04-01 Updated RELATION is a GO:0006099 (tricarboxylic acid cycle)
2008-04-01 Updated RELATION is a GO:0015977 (carbon fixation)
2007-08-09 Added SYNONYM reductive Kreb's cycle
2007-08-09 Added SYNONYM reductive TCA cycle
2007-08-09 Added SYNONYM reductive carboxylate cycle
2007-08-09 Added SYNONYM reductive carboxylic acid cycle
2007-08-09 Added SYNONYM reductive citric acid pathway
2007-08-09 Deleted SYNONYM reductive Kreb's cycle
2007-08-09 Deleted SYNONYM reductive TCA cycle
2007-08-09 Deleted SYNONYM reductive carboxylate cycle
2007-08-09 Deleted SYNONYM reductive carboxylic acid cycle
2007-08-09 Deleted SYNONYM reductive citric acid pathway
2006-05-06 Added SYNONYM reductive carboxylate cycle
2005-07-29 Added SYNONYM reductive TCA cycle
2005-07-29 Added SYNONYM reductive citric acid pathway
2005-07-29 Added SECONDARY GO:0019644 (reductive citric acid pathway)
2005-07-29 Added XREF MetaCyc:REDCITCYC
2005-07-18 Added SYNONYM reductive Kreb's cycle
2005-07-18 Added SYNONYM reductive carboxylic acid cycle
2005-07-16 Added DEFINITION A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
2003-10-27 Added XREF MetaCyc:P23-PWY
2001-10-22 Added TERM reductive tricarboxylic acid cycle

Term

Timestamp Action Category Detail
2001-10-22 Added TERM reductive tricarboxylic acid cycle

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
2008-05-12 Deleted DEFINITION A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.
2007-08-09 Added SYNONYM reductive Kreb's cycle
2007-08-09 Added SYNONYM reductive TCA cycle
2007-08-09 Added SYNONYM reductive carboxylate cycle
2007-08-09 Added SYNONYM reductive carboxylic acid cycle
2007-08-09 Added SYNONYM reductive citric acid pathway
2007-08-09 Deleted SYNONYM reductive Kreb's cycle
2007-08-09 Deleted SYNONYM reductive TCA cycle
2007-08-09 Deleted SYNONYM reductive carboxylate cycle
2007-08-09 Deleted SYNONYM reductive carboxylic acid cycle
2007-08-09 Deleted SYNONYM reductive citric acid pathway
2006-05-06 Added SYNONYM reductive carboxylate cycle
2005-07-29 Added SYNONYM reductive TCA cycle
2005-07-29 Added SYNONYM reductive citric acid pathway
2005-07-18 Added SYNONYM reductive Kreb's cycle
2005-07-18 Added SYNONYM reductive carboxylic acid cycle
2005-07-16 Added DEFINITION A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0006099 (tricarboxylic acid cycle)
2008-04-01 Updated RELATION is a GO:0015977 (carbon fixation)

Cross-references

Timestamp Action Category Detail
2005-07-29 Added XREF MetaCyc:REDCITCYC
2003-10-27 Added XREF MetaCyc:P23-PWY

Other

Timestamp Action Category Detail
2005-07-29 Added SECONDARY GO:0019644 (reductive citric acid pathway)
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