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GO:0019221 cytokine-mediated signaling pathway

Term Information

ID GO:0019221
Name cytokine-mediated signaling pathway
Ontology Biological Process
Definition A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
PMID:19295629
GONUTS GO:0019221 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact cytokine and chemokine mediated signaling pathway
exact cytokine mediated signalling pathway

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR011365
InterPro IPR029838
InterPro IPR029839
InterPro IPR029874

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019221:
Relationship To GO:0019221 Child Term Child Term Name
Regulates GO:0001959 regulation of cytokine-mediated signaling pathway
Negatively regulates GO:0001960 negative regulation of cytokine-mediated signaling pathway
Is a GO:0038109 Kit signaling pathway
Is a GO:0038110 interleukin-2-mediated signaling pathway
Is a GO:0038111 interleukin-7-mediated signaling pathway
Is a GO:0038112 interleukin-8-mediated signaling pathway
Is a GO:0038113 interleukin-9-mediated signaling pathway
Is a GO:0038114 interleukin-21-mediated signaling pathway
Positively regulates GO:0001961 positive regulation of cytokine-mediated signaling pathway
Is a GO:0070098 chemokine-mediated signaling pathway
Part of GO:0004896 cytokine receptor activity
Is a GO:0070102 interleukin-6-mediated signaling pathway
Is a GO:0070106 interleukin-27-mediated signaling pathway
Is a GO:0070120 ciliary neurotrophic factor-mediated signaling pathway
Is a GO:0033209 tumor necrosis factor-mediated signaling pathway
Is a GO:0033210 leptin-mediated signaling pathway
Is a GO:0033211 adiponectin-activated signaling pathway
Is a GO:0060333 interferon-gamma-mediated signaling pathway
Is a GO:0060337 type I interferon signaling pathway
Is a GO:0070498 interleukin-1-mediated signaling pathway
Is a GO:0070757 interleukin-35-mediated signaling pathway
Is a GO:0035723 interleukin-15-mediated signaling pathway
Is a GO:0035722 interleukin-12-mediated signaling pathway
Is a GO:0038157 granulocyte-macrophage colony-stimulating factor signaling pathway
Is a GO:0038158 granulocyte colony-stimulating factor signaling pathway
Is a GO:0038161 prolactin signaling pathway
Is a GO:0038162 erythropoietin-mediated signaling pathway
Is a GO:0038165 oncostatin-M-mediated signaling pathway
Is a GO:0038145 macrophage colony-stimulating factor signaling pathway
Is a GO:0061514 interleukin-34-mediated signaling pathway
Is a GO:0035655 interleukin-18-mediated signaling pathway
Is a GO:0097399 interleukin-32-mediated signaling pathway
Is a GO:0097400 interleukin-17-mediated signaling pathway
Is a GO:0035771 interleukin-4-mediated signaling pathway
Is a GO:0035772 interleukin-13-mediated signaling pathway
Is a GO:0038196 type III interferon signaling pathway
Is a GO:0038043 interleukin-5-mediated signaling pathway
Is a GO:0038154 interleukin-11-mediated signaling pathway
Is a GO:0038155 interleukin-23-mediated signaling pathway
Is a GO:0038156 interleukin-3-mediated signaling pathway
Is a GO:0035691 macrophage migration inhibitory factor signaling pathway
Is a GO:0038172 interleukin-33-mediated signaling pathway
Is a GO:0038173 interleukin-17A-mediated signaling pathway

Protein Annotation

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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0019221. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0019221 based on the entire annotation set Co-occurrence statistics for GO:0019221 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-14 Deleted DEFINITION Any series of molecular signals generated as a consequence of a cytokine binding to a cell surface receptor.
2012-01-14 Added DEFINITION A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2011-09-09 Deleted DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2011-09-09 Added DEFINITION Any series of molecular signals generated as a consequence of a cytokine binding to a cell surface receptor.
2011-01-30 Added RELATION is a GO:0071345 (cellular response to cytokine stimulus)
2010-10-28 Deleted RELATION is a GO:0023049 (signal initiation by protein/peptide mediator)
2010-04-14 Added RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023049 (signal initiation by protein/peptide mediator)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Deleted RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2008-11-15 Updated TERM cytokine-mediated signaling pathway
2008-11-13 Updated TERM cytokine mediated signaling pathway
2008-11-13 Added SYNONYM cytokine and chemokine mediated signaling pathway
2008-11-13 Added SYNONYM cytokine mediated signalling pathway
2008-11-13 Deleted SYNONYM cytokine and chemokine mediated signalling pathway
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2007-08-09 Added SYNONYM cytokine and chemokine mediated signalling pathway
2007-08-09 Deleted SYNONYM cytokine and chemokine mediated signalling pathway
2004-07-17 Added DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2004-04-19 Added SYNONYM cytokine and chemokine mediated signalling pathway
2004-04-16 Deleted SYNONYM cytokine and chemokine mediated signalling pathway
2003-11-13 Added SYNONYM cytokine and chemokine mediated signalling pathway
2001-10-03 Added TERM cytokine and chemokine mediated signaling pathway

Term

Timestamp Action Category Detail
2008-11-15 Updated TERM cytokine-mediated signaling pathway
2008-11-13 Updated TERM cytokine mediated signaling pathway
2001-10-03 Added TERM cytokine and chemokine mediated signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-01-14 Deleted DEFINITION Any series of molecular signals generated as a consequence of a cytokine binding to a cell surface receptor.
2012-01-14 Added DEFINITION A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2011-09-09 Deleted DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2011-09-09 Added DEFINITION Any series of molecular signals generated as a consequence of a cytokine binding to a cell surface receptor.
2008-11-13 Added SYNONYM cytokine and chemokine mediated signaling pathway
2008-11-13 Added SYNONYM cytokine mediated signalling pathway
2008-11-13 Deleted SYNONYM cytokine and chemokine mediated signalling pathway
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2007-08-09 Added SYNONYM cytokine and chemokine mediated signalling pathway
2007-08-09 Deleted SYNONYM cytokine and chemokine mediated signalling pathway
2004-07-17 Added DEFINITION Any series of molecular signals generated as a consequence of a cytokine or chemokine binding to a cell surface receptor.
2004-04-19 Added SYNONYM cytokine and chemokine mediated signalling pathway
2004-04-16 Deleted SYNONYM cytokine and chemokine mediated signalling pathway
2003-11-13 Added SYNONYM cytokine and chemokine mediated signalling pathway

Relationships

Timestamp Action Category Detail
2011-01-30 Added RELATION is a GO:0071345 (cellular response to cytokine stimulus)
2010-10-28 Deleted RELATION is a GO:0023049 (signal initiation by protein/peptide mediator)
2010-04-14 Added RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023049 (signal initiation by protein/peptide mediator)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Deleted RELATION is a GO:0007166 (cell surface receptor signaling pathway)
2008-04-01 Updated RELATION is a GO:0007166 (cell surface receptor signaling pathway)
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