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GO:0019005 SCF ubiquitin ligase complex

A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).

Term Information

ID GO:0019005
Name SCF ubiquitin ligase complex
Ontology Cellular Component
Definition A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Comment

Synonyms

Type Synonym
exact CDL1 complex
exact CRL1 complex
exact Cul1-RING ubiquitin ligase complex
exact SCF complex
narrow SCF complex substrate recognition subunit
exact Skp1/Cul1/F-box protein complex
exact cullin-RING ligase 1

Cross-references associated with this term:

Database ID
Wikipedia SCF_complex

This term can be used instead of these obsolete terms:

GO:0009839 SCF complex substrate recognition subunit (replaced_by GO:0019005)

Web service: term information

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0005575 cellular_component
GO:0032991 macromolecular complex
GO:0005623 cell
GO:0044464 cell part
GO:0043234 protein complex
GO:0005622 intracellular
GO:0044424 intracellular part
GO:0000151 ubiquitin ligase complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0019005 SCF ubiquitin ligase complex

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0043223 cytoplasmic SCF ubiquitin ligase complex
I GO:0043224 nuclear SCF ubiquitin ligase complex

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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