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GO:0019005 SCF ubiquitin ligase complex

Term Information

ID GO:0019005
Name SCF ubiquitin ligase complex
Ontology Cellular Component
Definition A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
PMID:15571813 PMID:15688063
GONUTS GO:0019005 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact CDL1 complex
exact CRL1 complex
exact Cul1-RING ubiquitin ligase complex
exact SCF complex
narrow SCF complex substrate recognition subunit
exact Skp1/Cul1/F-box protein complex
exact cullin-RING ligase 1

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR026941
InterPro IPR027046
Wikipedia SCF_complex

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0009839 SCF complex substrate recognition subunit REPLACEDBY GO:0019005

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0019005:
Relationship To GO:0019005 Child Term Child Term Name
Is a GO:0043223 cytoplasmic SCF ubiquitin ligase complex
Is a GO:0043224 nuclear SCF ubiquitin ligase complex

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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ID Mapping

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0019005. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0019005 based on the entire annotation set Co-occurrence statistics for GO:0019005 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-02-08 Added XREF Wikipedia:SCF_complex
2008-05-13 Added DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2008-04-01 Updated RELATION is a GO:0031461 (cullin-RING ubiquitin ligase complex)
2007-08-09 Added SYNONYM CDL1 complex
2007-08-09 Added SYNONYM CRL1 complex
2007-08-09 Added SYNONYM Cul1-RING ubiquitin ligase complex
2007-08-09 Added SYNONYM SCF complex
2007-08-09 Added SYNONYM SCF complex substrate recognition subunit
2007-08-09 Added SYNONYM Skp1/Cul1/F-box protein complex
2007-08-09 Added SYNONYM cullin-RING ligase 1
2007-08-09 Deleted SYNONYM CDL1 complex
2007-08-09 Deleted SYNONYM CRL1 complex
2007-08-09 Deleted SYNONYM Cul1-RING ubiquitin ligase complex
2007-08-09 Deleted SYNONYM SCF complex
2007-08-09 Deleted SYNONYM SCF complex substrate recognition subunit
2007-08-09 Deleted SYNONYM Skp1/Cul1/F-box protein complex
2007-08-09 Deleted SYNONYM cullin-RING ligase 1
2006-09-29 Updated DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2005-08-10 Added SYNONYM SCF complex substrate recognition subunit
2005-06-16 Added SYNONYM Cul1-RING ubiquitin ligase complex
2005-06-16 Added SYNONYM cullin-RING ligase 1
2005-06-15 Deleted SYNONYM cullin complex
2005-06-15 Added SYNONYM CDL1 complex
2005-06-15 Added SYNONYM CRL1 complex
2005-06-11 Updated DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome.The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2004-04-19 Added SYNONYM SCF complex
2004-04-19 Added SYNONYM Skp1/Cul1/F-box protein complex
2004-04-19 Added SYNONYM cullin complex
2004-04-16 Deleted SYNONYM SCF complex
2004-04-16 Deleted SYNONYM Skp1/Cul1/F-box protein complex
2004-04-16 Deleted SYNONYM cullin complex
2003-06-28 Added SYNONYM cullin complex
2003-03-19 Deleted SYNONYM Skp1/ Cul1/F-BOX protein complex
2003-03-19 Deleted SYNONYM Skp1/ Cul1/F-box protein complex
2002-12-17 Added SYNONYM Skp1/Cul1/F-box protein complex
2002-11-27 Updated TERM SCF ubiquitin ligase complex
2002-11-27 Added DEFINITION A protein complex usually consisting of three conserved polypeptides (named Skp1, Cdc53/Cul1, Rbx1/Hrt1 in yeast and mammals) and one variable polypeptide (F-box protein), which is involved in the targeting of proteins for proteasome degradation.
2002-11-27 Added SYNONYM SCF complex
2002-11-27 Added SYNONYM Skp1/ Cul1/F-box protein complex
2002-07-09 Added SYNONYM Skp1/ Cul1/F-BOX protein complex
2001-10-01 Added TERM SCF complex

Term

Timestamp Action Category Detail
2002-11-27 Updated TERM SCF ubiquitin ligase complex
2001-10-01 Added TERM SCF complex

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2008-05-12 Deleted DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2007-08-09 Added SYNONYM CDL1 complex
2007-08-09 Added SYNONYM CRL1 complex
2007-08-09 Added SYNONYM Cul1-RING ubiquitin ligase complex
2007-08-09 Added SYNONYM SCF complex
2007-08-09 Added SYNONYM SCF complex substrate recognition subunit
2007-08-09 Added SYNONYM Skp1/Cul1/F-box protein complex
2007-08-09 Added SYNONYM cullin-RING ligase 1
2007-08-09 Deleted SYNONYM CDL1 complex
2007-08-09 Deleted SYNONYM CRL1 complex
2007-08-09 Deleted SYNONYM Cul1-RING ubiquitin ligase complex
2007-08-09 Deleted SYNONYM SCF complex
2007-08-09 Deleted SYNONYM SCF complex substrate recognition subunit
2007-08-09 Deleted SYNONYM Skp1/Cul1/F-box protein complex
2007-08-09 Deleted SYNONYM cullin-RING ligase 1
2006-09-29 Updated DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2005-08-10 Added SYNONYM SCF complex substrate recognition subunit
2005-06-16 Added SYNONYM Cul1-RING ubiquitin ligase complex
2005-06-16 Added SYNONYM cullin-RING ligase 1
2005-06-15 Deleted SYNONYM cullin complex
2005-06-15 Added SYNONYM CDL1 complex
2005-06-15 Added SYNONYM CRL1 complex
2005-06-11 Updated DEFINITION A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome.The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
2004-04-19 Added SYNONYM SCF complex
2004-04-19 Added SYNONYM Skp1/Cul1/F-box protein complex
2004-04-19 Added SYNONYM cullin complex
2004-04-16 Deleted SYNONYM SCF complex
2004-04-16 Deleted SYNONYM Skp1/Cul1/F-box protein complex
2004-04-16 Deleted SYNONYM cullin complex
2003-06-28 Added SYNONYM cullin complex
2003-03-19 Deleted SYNONYM Skp1/ Cul1/F-BOX protein complex
2003-03-19 Deleted SYNONYM Skp1/ Cul1/F-box protein complex
2002-12-17 Added SYNONYM Skp1/Cul1/F-box protein complex
2002-11-27 Added DEFINITION A protein complex usually consisting of three conserved polypeptides (named Skp1, Cdc53/Cul1, Rbx1/Hrt1 in yeast and mammals) and one variable polypeptide (F-box protein), which is involved in the targeting of proteins for proteasome degradation.
2002-11-27 Added SYNONYM SCF complex
2002-11-27 Added SYNONYM Skp1/ Cul1/F-box protein complex
2002-07-09 Added SYNONYM Skp1/ Cul1/F-BOX protein complex

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0031461 (cullin-RING ubiquitin ligase complex)

Cross-references

Timestamp Action Category Detail
2009-02-08 Added XREF Wikipedia:SCF_complex
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