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GO:0018279 protein amino acid N-linked glycosylation via asparagine

The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.

Term Information

ID GO:0018279
Name protein amino acid N-linked glycosylation via asparagine
Ontology Biological Process
Definition The posttranslational glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine also occurs; this modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification.
Comment

Cross-references associated with this term:

Database ID
INTERPRO IPR005013
RESID AA0151
INTERPRO IPR008814

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Ancestor Table

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0044238 primary metabolic process
GO:0043170 macromolecule metabolic process
GO:0005975 carbohydrate metabolic process
GO:0044237 cellular metabolic process
GO:0043283 biopolymer metabolic process
GO:0043412 biopolymer modification
GO:0009059 macromolecule biosynthetic process
GO:0070085 glycosylation
GO:0044260 cellular macromolecule metabolic process
GO:0044249 cellular biosynthetic process
GO:0019538 protein metabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0034960 cellular biopolymer metabolic process
GO:0009100 glycoprotein metabolic process
GO:0043413 biopolymer glycosylation
GO:0034645 cellular macromolecule biosynthetic process
GO:0044267 cellular protein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0006464 protein modification process
GO:0018193 peptidyl-amino acid modification
GO:0018196 peptidyl-asparagine modification
GO:0006486 protein amino acid glycosylation
GO:0006487 protein amino acid N-linked glycosylation
GO:0018279 protein amino acid N-linked glycosylation via asparagine

Relationship key

Code Relationship
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+ve regulates
-ve regulates

Child Terms

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Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
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Co-occurring Terms

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