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GO:0018081 peptide cross-linking via lanthionine or 3-methyl-lanthionine

Term Information

ID GO:0018081
Name peptide cross-linking via lanthionine or 3-methyl-lanthionine
Ontology Biological Process
Definition The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
GONUTS GO:0018081 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
exact peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine

Cross-references

Database ID
RESID AA0110
RESID AA0111
RESID AA0112

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0018081:
Relationship To GO:0018081 Child Term Child Term Name
Is a GO:0018154 peptide cross-linking via (2R,6R)-lanthionine
Is a GO:0018155 peptide cross-linking via sn-(2S,6R)-lanthionine

Protein Annotation

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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0018081. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0018081 based on the entire annotation set Co-occurrence statistics for GO:0018081 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-15 Added DEFINITION The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2010-10-15 Deleted DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2008-05-13 Added DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2008-05-12 Deleted DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2008-04-01 Updated RELATION is a GO:0018149 (peptide cross-linking)
2007-08-09 Added SYNONYM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2007-08-09 Added SYNONYM peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine
2007-08-09 Deleted SYNONYM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2007-08-09 Deleted SYNONYM peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine
2006-02-09 Updated TERM peptide cross-linking via lanthionine or 3-methyl-lanthionine
2006-02-09 Added SYNONYM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2006-02-09 Added SYNONYM peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine
2005-02-24 Added XREF RESID:AA0112
2005-02-24 Added XREF RESID:AA0111
2005-02-24 Added XREF RESID:AA0110
2004-09-24 Updated DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2003-04-24 Updated DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2002-11-27 Added DEFINITION The post-translational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2001-11-23 Updated TERM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2001-10-01 Added TERM protein-protein cross-linking via lanthionine

Term

Timestamp Action Category Detail
2006-02-09 Updated TERM peptide cross-linking via lanthionine or 3-methyl-lanthionine
2001-11-23 Updated TERM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2001-10-01 Added TERM protein-protein cross-linking via lanthionine

Definition/synonyms

Timestamp Action Category Detail
2010-10-15 Added DEFINITION The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2010-10-15 Deleted DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2008-05-13 Added DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2008-05-12 Deleted DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2007-08-09 Added SYNONYM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2007-08-09 Added SYNONYM peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine
2007-08-09 Deleted SYNONYM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2007-08-09 Deleted SYNONYM peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine
2006-02-09 Added SYNONYM peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine
2006-02-09 Added SYNONYM peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine
2004-09-24 Updated DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2003-04-24 Updated DEFINITION The posttranslational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.
2002-11-27 Added DEFINITION The post-translational synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0018149 (peptide cross-linking)

Cross-references

Timestamp Action Category Detail
2005-02-24 Added XREF RESID:AA0112
2005-02-24 Added XREF RESID:AA0111
2005-02-24 Added XREF RESID:AA0110
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