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GO:0018024 histone-lysine N-methyltransferase activity

Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.

Term Information

ID GO:0018024
Name histone-lysine N-methyltransferase activity
Ontology Molecular Function
Definition Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
Comment

Synonyms

Type Synonym
narrow protein methyltransferase II activity
narrow protein methylase III activity
narrow protein methylase 3 activity
exact protein (lysine) methyltransferase activity
exact histone-lysine N-methylase activity
exact S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity
exact histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity
exact S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity

Cross-references associated with this term:

Database ID
INTERPRO IPR006560
INTERPRO IPR017111
INTERPRO IPR011381
INTERPRO IPR017155
INTERPRO IPR013110
INTERPRO IPR003606
INTERPRO IPR007728
EC 2.1.1.43
MetaCyc HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN
RESID AA0074
RESID AA0075
RESID AA0076
INTERPRO IPR013257

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016741 transferase activity, transferring one-carbon groups
GO:0008168 methyltransferase activity
GO:0008170 N-methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0016278 lysine N-methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0018024 histone-lysine N-methyltransferase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0042799 histone methyltransferase activity (H4-K20 specific)
I GO:0042800 histone methyltransferase activity (H3-K4 specific)
I GO:0046974 histone methyltransferase activity (H3-K9 specific)
I GO:0046975 histone methyltransferase activity (H3-K36 specific)
I GO:0046976 histone methyltransferase activity (H3-K27 specific)
I GO:0031151 histone methyltransferase activity (H3-K79 specific)

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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