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GO:0018024 histone-lysine N-methyltransferase activity

Term Information

ID GO:0018024
Name histone-lysine N-methyltransferase activity
Ontology Molecular Function
Definition Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
GONUTS GO:0018024 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow protein methylase 3 activity
narrow protein methylase III activity
exact histone-lysine N-methylase activity
narrow protein methyltransferase II activity
exact S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity
exact S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity
exact histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity
exact protein (lysine) methyltransferase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.1.1.43
InterPro IPR006560
InterPro IPR007728
InterPro IPR011381
InterPro IPR013257
InterPro IPR015722
InterPro IPR016858
InterPro IPR017111
InterPro IPR017155
InterPro IPR018848
InterPro IPR021162
InterPro IPR021169
InterPro IPR021654
InterPro IPR025789
InterPro IPR025805
InterPro IPR032926
InterPro IPR033498
MetaCyc HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN
RESID AA0074
RESID AA0075
RESID AA0076

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0018024:
Relationship To GO:0018024 Child Term Child Term Name
Is a GO:0042799 histone methyltransferase activity (H4-K20 specific)
Is a GO:0042800 histone methyltransferase activity (H3-K4 specific)
Is a GO:0046974 histone methyltransferase activity (H3-K9 specific)
Is a GO:0046975 histone methyltransferase activity (H3-K36 specific)
Is a GO:0046976 histone methyltransferase activity (H3-K27 specific)
Is a GO:0031151 histone methyltransferase activity (H3-K79 specific)

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
Evidence
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Date
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Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0018024. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0018024 based on the entire annotation set Co-occurrence statistics for GO:0018024 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-07-16 Added RELATION part of GO:0034968 (histone lysine methylation)
2009-07-23 Added SYNONYM histone-lysine N-methylase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2008-04-01 Updated RELATION is a GO:0016279 (protein-lysine N-methyltransferase activity)
2008-04-01 Updated RELATION is a GO:0042054 (histone methyltransferase activity)
2007-11-08 Added SYNONYM S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity
2007-11-08 Added SYNONYM S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity
2007-11-08 Added SYNONYM histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity
2007-11-08 Added SYNONYM protein (lysine) methyltransferase activity
2007-09-06 Added SYNONYM protein methylase 3 activity
2007-09-06 Added SYNONYM protein methylase III activity
2007-09-06 Added SYNONYM protein methyltransferase II activity
2005-02-24 Added XREF RESID:AA0076
2005-02-24 Added XREF RESID:AA0075
2005-02-24 Added XREF RESID:AA0074
2003-10-27 Added XREF MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN
2003-03-26 Updated DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2003-03-19 Updated TERM histone-lysine N-methyltransferase activity
2002-11-27 Added DEFINITION The methylation of peptidyl-lysine in histones to form the histone N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2001-10-01 Added XREF EC:2.1.1.43
2001-10-01 Added TERM histone-lysine N-methyltransferase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM histone-lysine N-methyltransferase activity
2001-10-01 Added TERM histone-lysine N-methyltransferase

Definition/synonyms

Timestamp Action Category Detail
2009-07-23 Added SYNONYM histone-lysine N-methylase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2007-11-08 Added SYNONYM S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity
2007-11-08 Added SYNONYM S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity
2007-11-08 Added SYNONYM histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity
2007-11-08 Added SYNONYM protein (lysine) methyltransferase activity
2007-09-06 Added SYNONYM protein methylase 3 activity
2007-09-06 Added SYNONYM protein methylase III activity
2007-09-06 Added SYNONYM protein methyltransferase II activity
2003-03-26 Updated DEFINITION Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
2002-11-27 Added DEFINITION The methylation of peptidyl-lysine in histones to form the histone N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.

Relationships

Timestamp Action Category Detail
2010-07-16 Added RELATION part of GO:0034968 (histone lysine methylation)
2008-04-01 Updated RELATION is a GO:0016279 (protein-lysine N-methyltransferase activity)
2008-04-01 Updated RELATION is a GO:0042054 (histone methyltransferase activity)

Cross-references

Timestamp Action Category Detail
2005-02-24 Added XREF RESID:AA0076
2005-02-24 Added XREF RESID:AA0075
2005-02-24 Added XREF RESID:AA0074
2003-10-27 Added XREF MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN
2001-10-01 Added XREF EC:2.1.1.43
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