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GO:0018024 histone-lysine N-methyltransferase activityCatalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
Term Information
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| Type | Synonym |
| narrow | protein methyltransferase II activity |
| narrow | protein methylase III activity |
| narrow | protein methylase 3 activity |
| exact | protein (lysine) methyltransferase activity |
| exact | histone-lysine N-methylase activity |
| exact | S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity |
| exact | histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity |
| exact | S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity |
| Database | ID |
| INTERPRO | IPR006560 |
| INTERPRO | IPR017111 |
| INTERPRO | IPR011381 |
| INTERPRO | IPR017155 |
| INTERPRO | IPR013110 |
| INTERPRO | IPR003606 |
| INTERPRO | IPR007728 |
| EC | 2.1.1.43 |
| MetaCyc | HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN |
| RESID | AA0074 |
| RESID | AA0075 |
| RESID | AA0076 |
| INTERPRO | IPR013257 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | |||||||||||
![]() | GO:0003824 catalytic activity | ||||||||||
![]() | ![]() | GO:0016740 transferase activity | |||||||||
![]() | ![]() | ![]() | GO:0016741 transferase activity, transferring one-carbon groups | ||||||||
![]() | ![]() | ![]() | ![]() | GO:0008168 methyltransferase activity | |||||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0008170 N-methyltransferase activity | ||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0008276 protein methyltransferase activity | |||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0008757 S-adenosylmethionine-dependent methyltransferase activity | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0042054 histone methyltransferase activity | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016278 lysine N-methyltransferase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016279 protein-lysine N-methyltransferase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0018024 histone-lysine N-methyltransferase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0042799 histone methyltransferase activity (H4-K20 specific) |
| I | GO:0042800 histone methyltransferase activity (H3-K4 specific) |
| I | GO:0046974 histone methyltransferase activity (H3-K9 specific) |
| I | GO:0046975 histone methyltransferase activity (H3-K36 specific) |
| I | GO:0046976 histone methyltransferase activity (H3-K27 specific) |
| I | GO:0031151 histone methyltransferase activity (H3-K79 specific) |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-8.ebi.ac.uk |
| Uptime | 17:46 13/10/2009 |
| Data version | 2009-11-21-04-03-45 |