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GO:0017136 NAD-dependent histone deacetylase activity

Term Information

ID GO:0017136
Name NAD-dependent histone deacetylase activity
Ontology Molecular Function
Definition Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
GONUTS GO:0017136 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related SIR2

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR007654

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0017136:
Relationship To GO:0017136 Child Term Child Term Name
Is a GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
Is a GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific)
Is a GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
Is a GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0017136. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0017136 based on the entire annotation set Co-occurrence statistics for GO:0017136 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-09-24 Added DEFINITION Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
2010-09-24 Deleted DEFINITION Catalysis of the removal of one or more acetyl groups from a histone, requiring NAD.
2008-10-02 Added RELATION is a GO:0034979 (NAD-dependent protein deacetylase activity)
2008-10-02 Added DEFINITION Catalysis of the removal of one or more acetyl groups from a histone, requiring NAD.
2008-10-02 Deleted DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.
2008-05-13 Added DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.
2008-05-12 Deleted DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.
2008-04-01 Updated RELATION is a GO:0004407 (histone deacetylase activity)
2007-08-09 Added SYNONYM SIR2
2007-08-09 Deleted SYNONYM SIR2
2007-08-04 Added SYNONYM SIR2
2003-03-26 Added DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.
2003-03-19 Updated TERM NAD-dependent histone deacetylase activity
2001-06-21 Added TERM NAD-dependent histone deacetylase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM NAD-dependent histone deacetylase activity
2001-06-21 Added TERM NAD-dependent histone deacetylase

Definition/synonyms

Timestamp Action Category Detail
2010-09-24 Added DEFINITION Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone.
2010-09-24 Deleted DEFINITION Catalysis of the removal of one or more acetyl groups from a histone, requiring NAD.
2008-10-02 Added DEFINITION Catalysis of the removal of one or more acetyl groups from a histone, requiring NAD.
2008-10-02 Deleted DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.
2008-05-13 Added DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.
2008-05-12 Deleted DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.
2007-08-09 Added SYNONYM SIR2
2007-08-09 Deleted SYNONYM SIR2
2007-08-04 Added SYNONYM SIR2
2003-03-26 Added DEFINITION Catalysis of the removal of acetyl groups from histones, requiring NAD.

Relationships

Timestamp Action Category Detail
2008-10-02 Added RELATION is a GO:0034979 (NAD-dependent protein deacetylase activity)
2008-04-01 Updated RELATION is a GO:0004407 (histone deacetylase activity)
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