spacer

GO:0016992 lipoate synthase activity

Term Information

ID GO:0016992
Name lipoate synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
PMID:18307109
Secondary IDs GO:0017140
GONUTS GO:0016992 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact lipoic acid synthase
related LipA
exact protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity
exact protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity
exact lipoyl synthase activity
related LS

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.8.1.8
InterPro IPR003698
InterPro IPR027526
InterPro IPR027527
MetaCyc RXN0-949

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016992:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016992. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016992 based on the entire annotation set Co-occurrence statistics for GO:0016992 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-04-08 Added RELATION part of GO:0009107 (lipoate biosynthetic process)
2011-04-08 Added SYNONYM lipoic acid synthase
2011-04-08 Added SECONDARY GO:0017140 (lipoic acid synthase activity)
2010-07-18 Added XREF MetaCyc:RXN0-949
2010-07-18 Deleted XREF MetaCyc:2.8.1.8-RXN
2009-05-21 Added XREF MetaCyc:2.8.1.8-RXN
2009-02-05 Added RELATION is a GO:0070283 (radical SAM enzyme activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
2008-04-01 Updated RELATION is a GO:0016979 (lipoate-protein ligase activity)
2008-04-01 Updated RELATION is a GO:0016783 (sulfurtransferase activity)
2007-12-27 Added DEFINITION Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
2007-12-06 Added SYNONYM LS
2007-12-06 Added SYNONYM LipA
2007-12-06 Added SYNONYM lipoyl synthase activity
2007-12-06 Added SYNONYM protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity
2007-12-06 Added SYNONYM protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity
2007-12-06 Added XREF EC:2.8.1.8
2003-03-19 Updated TERM lipoate synthase activity
2001-04-03 Added TERM lipoate synthase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM lipoate synthase activity
2001-04-03 Added TERM lipoate synthase

Definition/synonyms

Timestamp Action Category Detail
2011-04-08 Added SYNONYM lipoic acid synthase
2008-05-13 Added DEFINITION Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
2007-12-27 Added DEFINITION Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
2007-12-06 Added SYNONYM LS
2007-12-06 Added SYNONYM LipA
2007-12-06 Added SYNONYM lipoyl synthase activity
2007-12-06 Added SYNONYM protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity
2007-12-06 Added SYNONYM protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity

Relationships

Timestamp Action Category Detail
2011-04-08 Added RELATION part of GO:0009107 (lipoate biosynthetic process)
2009-02-05 Added RELATION is a GO:0070283 (radical SAM enzyme activity)
2008-04-01 Updated RELATION is a GO:0016979 (lipoate-protein ligase activity)
2008-04-01 Updated RELATION is a GO:0016783 (sulfurtransferase activity)

Cross-references

Timestamp Action Category Detail
2010-07-18 Added XREF MetaCyc:RXN0-949
2010-07-18 Deleted XREF MetaCyc:2.8.1.8-RXN
2009-05-21 Added XREF MetaCyc:2.8.1.8-RXN
2007-12-06 Added XREF EC:2.8.1.8

Other

Timestamp Action Category Detail
2011-04-08 Added SECONDARY GO:0017140 (lipoic acid synthase activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
12ms