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GO:0016987 sigma factor activity

Term Information

ID GO:0016987
Name sigma factor activity
Ontology Molecular Function
Definition A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
GONUTS GO:0016987 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related sigma transcription factor

Cross-references

Database ID
InterPro IPR000394
InterPro IPR000838
InterPro IPR000943
InterPro IPR007624
InterPro IPR007627
InterPro IPR007630
InterPro IPR007631
InterPro IPR008771
InterPro IPR009042
InterPro IPR012759
InterPro IPR012760
InterPro IPR012761
InterPro IPR012845
InterPro IPR013249
InterPro IPR013324
InterPro IPR013325
InterPro IPR014200
InterPro IPR014209
InterPro IPR014212
InterPro IPR014218
InterPro IPR014236
InterPro IPR014284
InterPro IPR014286
InterPro IPR014288
InterPro IPR014293
InterPro IPR014296
InterPro IPR014322
InterPro IPR016263
InterPro IPR016371
InterPro IPR028617
InterPro IPR028630
UniProtKB-KW Sigma factor

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016987:
Relationship To GO:0016987 Child Term Child Term Name
Is a GO:0001053 plastid sigma factor activity
Has part GO:0000985 bacterial-type RNA polymerase core promoter sequence-specific DNA binding
Has part GO:0001000 bacterial-type RNA polymerase core enzyme binding

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016987. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016987 based on the entire annotation set Co-occurrence statistics for GO:0016987 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-09-03 Added RELATION is a GO:0000996 (core DNA-dependent RNA polymerase binding promoter specificity activity)
2010-09-03 Deleted RELATION is a GO:0016986 (transcription initiation factor activity)
2008-05-13 Added DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2008-05-12 Deleted DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2008-04-01 Updated RELATION is a GO:0016986 (transcription initiation factor activity)
2008-02-10 Added SYNONYM sigma transcription factor
2003-10-23 Updated DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2003-04-12 Updated DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promotor elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2003-03-26 Updated DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids.) Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promotor elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2003-03-19 Updated TERM sigma factor activity
2001-08-06 Added DEFINITION A RNA polymerase initiating factor of bacteria; promotes the attachment of the RNA polymerase, of which it is a subunit, to specific initiation sites; it is then released.
2001-04-03 Added TERM sigma factor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM sigma factor activity
2001-04-03 Added TERM sigma factor

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2008-05-12 Deleted DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2008-02-10 Added SYNONYM sigma transcription factor
2003-10-23 Updated DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2003-04-12 Updated DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promotor elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2003-03-26 Updated DEFINITION A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids.) Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promotor elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes.
2001-08-06 Added DEFINITION A RNA polymerase initiating factor of bacteria; promotes the attachment of the RNA polymerase, of which it is a subunit, to specific initiation sites; it is then released.

Relationships

Timestamp Action Category Detail
2010-09-03 Added RELATION is a GO:0000996 (core DNA-dependent RNA polymerase binding promoter specificity activity)
2010-09-03 Deleted RELATION is a GO:0016986 (transcription initiation factor activity)
2008-04-01 Updated RELATION is a GO:0016986 (transcription initiation factor activity)
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