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GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Term Information

ID GO:0004748
Name ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Ontology Molecular Function
Definition Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
Comment When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'.
Secondary IDs GO:0016959 GO:0016960 GO:0016961
GONUTS GO:0004748 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity
exact 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity
exact nucleoside diphosphate reductase activity
exact ribonucleoside 5'-diphosphate reductase activity
exact ribonucleoside diphosphate reductase activity
exact ribonucleotide diphosphate reductase activity
exact class II ribonucleoside-diphosphate reductase activity
exact anaerobic iron-sulfur-dependent ribonucleotide reductase activity
exact class I ribonucleotide reductase activity
exact RNR
related purine/pyrimidine nucleoside diphosphate reduction
broad ribonucleoside-diphosphate reductase activity
exact class II ribonucleotide reductase activity
exact adenosylcobalamin-dependent ribonucleotide reductase activity
exact aerobic non-heme iron-dependent ribonucleotide reductase activity
exact class III ribonucleotide reductase activity
broad ribonucleotide reductase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.17.4.1
InterPro IPR013344
InterPro IPR013345
InterPro IPR013509
InterPro IPR013678
MetaCyc RIBONUCLEOSIDE-DIP-REDUCTI-RXN
RHEA 23255

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0006162 purine/pyrimidine nucleoside diphosphate reduction CONSIDER GO:0004748

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004748:
Relationship To GO:0004748 Child Term Child Term Name
Is a GO:0051061 ADP reductase activity
Is a GO:0051062 UDP reductase activity
Is a GO:0051063 CDP reductase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004748. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004748 based on the entire annotation set Co-occurrence statistics for GO:0004748 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-03-31 Updated TERM ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
2012-03-31 Added SYNONYM ribonucleoside-diphosphate reductase activity
2011-09-16 Added XREF RHEA:23255
2010-07-23 Added SYNONYM adenosylcobalamin-dependent ribonucleotide reductase activity
2010-07-23 Added SYNONYM class I ribonucleotide reductase activity
2010-07-23 Added SYNONYM anaerobic iron-sulfur-dependent ribonucleotide reductase activity
2010-07-23 Added SYNONYM class II ribonucleoside-diphosphate reductase activity
2010-07-23 Added SYNONYM class II ribonucleotide reductase activity
2010-07-23 Added SYNONYM aerobic non-heme iron-dependent ribonucleotide reductase activity
2010-07-23 Added SYNONYM class III ribonucleotide reductase activity
2010-07-23 Added SECONDARY GO:0016961 (class III ribonucleotide reductase activity)
2010-07-23 Added SECONDARY GO:0016960 (class II ribonucleotide reductase activity)
2010-07-23 Added SECONDARY GO:0016959 (class I ribonucleotide reductase activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
2008-04-01 Updated RELATION is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor)
2007-11-08 Added SYNONYM 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity
2007-11-08 Added SYNONYM 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity
2007-11-08 Added SYNONYM nucleoside diphosphate reductase activity
2007-11-08 Added SYNONYM ribonucleoside 5'-diphosphate reductase activity
2007-11-08 Added SYNONYM ribonucleoside diphosphate reductase activity
2007-11-08 Added SYNONYM ribonucleotide diphosphate reductase activity
2007-09-06 Added SYNONYM ribonucleotide reductase activity
2007-09-06 Deleted SYNONYM ribonucleotide reductase
2007-08-09 Added SYNONYM RNR
2007-08-09 Added SYNONYM purine/pyrimidine nucleoside diphosphate reduction
2007-08-09 Added SYNONYM ribonucleotide reductase
2007-08-09 Deleted SYNONYM RNR
2007-08-09 Deleted SYNONYM purine/pyrimidine nucleoside diphosphate reduction
2007-08-09 Deleted SYNONYM ribonucleotide reductase
2006-02-04 Updated DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
2005-10-02 Added SYNONYM RNR
2005-08-10 Added SYNONYM purine/pyrimidine nucleoside diphosphate reduction
2004-04-19 Added SYNONYM ribonucleotide reductase
2004-04-16 Deleted SYNONYM ribonucleotide reductase
2003-10-27 Added SYNONYM ribonucleotide reductase
2003-10-27 Added XREF MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN
2003-08-22 Deleted SYNONYM ribonucleotide reductase
2003-03-19 Updated TERM ribonucleoside-diphosphate reductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O = ribonucleoside diphosphate + reduced thioredoxin.
2002-02-06 Updated TERM ribonucleoside-diphosphate reductase
2001-04-03 Updated TERM ribonucleoside-diphosphate reductase
2001-03-30 Added XREF EC:1.17.4.1
2001-03-30 Added SYNONYM ribonucleotide reductase
2001-03-30 Added TERM ribonucleoside-diphosphate reductase

Term

Timestamp Action Category Detail
2012-03-31 Updated TERM ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
2003-03-19 Updated TERM ribonucleoside-diphosphate reductase activity
2002-02-06 Updated TERM ribonucleoside-diphosphate reductase
2001-04-03 Updated TERM ribonucleoside-diphosphate reductase
2001-03-30 Added TERM ribonucleoside-diphosphate reductase

Definition/synonyms

Timestamp Action Category Detail
2012-03-31 Added SYNONYM ribonucleoside-diphosphate reductase activity
2010-07-23 Added SYNONYM adenosylcobalamin-dependent ribonucleotide reductase activity
2010-07-23 Added SYNONYM class I ribonucleotide reductase activity
2010-07-23 Added SYNONYM anaerobic iron-sulfur-dependent ribonucleotide reductase activity
2010-07-23 Added SYNONYM class II ribonucleoside-diphosphate reductase activity
2010-07-23 Added SYNONYM class II ribonucleotide reductase activity
2010-07-23 Added SYNONYM aerobic non-heme iron-dependent ribonucleotide reductase activity
2010-07-23 Added SYNONYM class III ribonucleotide reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
2007-11-08 Added SYNONYM 2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity
2007-11-08 Added SYNONYM 2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity
2007-11-08 Added SYNONYM nucleoside diphosphate reductase activity
2007-11-08 Added SYNONYM ribonucleoside 5'-diphosphate reductase activity
2007-11-08 Added SYNONYM ribonucleoside diphosphate reductase activity
2007-11-08 Added SYNONYM ribonucleotide diphosphate reductase activity
2007-09-06 Added SYNONYM ribonucleotide reductase activity
2007-09-06 Deleted SYNONYM ribonucleotide reductase
2007-08-09 Added SYNONYM RNR
2007-08-09 Added SYNONYM purine/pyrimidine nucleoside diphosphate reduction
2007-08-09 Added SYNONYM ribonucleotide reductase
2007-08-09 Deleted SYNONYM RNR
2007-08-09 Deleted SYNONYM purine/pyrimidine nucleoside diphosphate reduction
2007-08-09 Deleted SYNONYM ribonucleotide reductase
2006-02-04 Updated DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin.
2005-10-02 Added SYNONYM RNR
2005-08-10 Added SYNONYM purine/pyrimidine nucleoside diphosphate reduction
2004-04-19 Added SYNONYM ribonucleotide reductase
2004-04-16 Deleted SYNONYM ribonucleotide reductase
2003-10-27 Added SYNONYM ribonucleotide reductase
2003-08-22 Deleted SYNONYM ribonucleotide reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O = ribonucleoside diphosphate + reduced thioredoxin.
2001-03-30 Added SYNONYM ribonucleotide reductase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor)

Cross-references

Timestamp Action Category Detail
2011-09-16 Added XREF RHEA:23255
2003-10-27 Added XREF MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN
2001-03-30 Added XREF EC:1.17.4.1

Other

Timestamp Action Category Detail
2010-07-23 Added SECONDARY GO:0016961 (class III ribonucleotide reductase activity)
2010-07-23 Added SECONDARY GO:0016960 (class II ribonucleotide reductase activity)
2010-07-23 Added SECONDARY GO:0016959 (class I ribonucleotide reductase activity)
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