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GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor

Term Information

ID GO:0016884
Name carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Ontology Molecular Function
Definition Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
PMID:12360532
Secondary IDs GO:0016003
GONUTS GO:0016884 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 6.3.5
InterPro IPR000120
InterPro IPR003789
InterPro IPR004413
InterPro IPR004414
InterPro IPR017958
InterPro IPR017959
InterPro IPR018027

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016884:
Relationship To GO:0016884 Child Term Child Term Name
Is a GO:0003922 GMP synthase (glutamine-hydrolyzing) activity
Is a GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity
Is a GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity
Is a GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Is a GO:0050566 asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
Is a GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
Is a GO:0004642 phosphoribosylformylglycinamidine synthase activity
Is a GO:0051921 adenosylcobyric acid synthase (glutamine-hydrolyzing) activity
Is a GO:0043775 cobyrinate a,c-diamide synthase activity
Is a GO:0043802 hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016884. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016884 based on the entire annotation set Co-occurrence statistics for GO:0016884 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2008-04-01 Updated RELATION is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds)
2007-11-08 Deleted SYNONYM glutamine amidotransferase
2007-08-09 Added SYNONYM glutamine amidotransferase
2007-08-09 Deleted SYNONYM glutamine amidotransferase
2006-02-09 Added XREF EC:6.3.5
2006-02-09 Deleted XREF EC:6.3.5.-
2004-04-19 Added SYNONYM glutamine amidotransferase
2004-04-16 Deleted SYNONYM glutamine amidotransferase
2003-08-06 Updated DEFINITION Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2003-03-26 Added DEFINITION Glutamine amidotransferases (GATases) are enzymes that transfer the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2003-03-25 Updated TERM carbon-nitrogen ligase activity, with glutamine as amido-N-donor
2003-03-19 Updated TERM carbon-nitrogen ligase, with glutamine as amido-N-donor activity
2003-01-11 Added SYNONYM glutamine amidotransferase
2003-01-11 Added SECONDARY GO:0016003 (glutamine amidotransferase)
2002-02-06 Updated TERM carbon-nitrogen ligase, with glutamine as amido-N-donor
2001-04-03 Updated TERM carbon-nitrogen ligase, with glutamine as amido-N-donor
2001-03-30 Added XREF EC:6.3.5.-
2001-03-30 Added TERM carbon-nitrogen ligase, with glutamine as amido-N-donor

Term

Timestamp Action Category Detail
2003-03-25 Updated TERM carbon-nitrogen ligase activity, with glutamine as amido-N-donor
2003-03-19 Updated TERM carbon-nitrogen ligase, with glutamine as amido-N-donor activity
2002-02-06 Updated TERM carbon-nitrogen ligase, with glutamine as amido-N-donor
2001-04-03 Updated TERM carbon-nitrogen ligase, with glutamine as amido-N-donor
2001-03-30 Added TERM carbon-nitrogen ligase, with glutamine as amido-N-donor

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2008-05-12 Deleted DEFINITION Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2007-11-08 Deleted SYNONYM glutamine amidotransferase
2007-08-09 Added SYNONYM glutamine amidotransferase
2007-08-09 Deleted SYNONYM glutamine amidotransferase
2004-04-19 Added SYNONYM glutamine amidotransferase
2004-04-16 Deleted SYNONYM glutamine amidotransferase
2003-08-06 Updated DEFINITION Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2003-03-26 Added DEFINITION Glutamine amidotransferases (GATases) are enzymes that transfer the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction.
2003-01-11 Added SYNONYM glutamine amidotransferase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:6.3.5
2006-02-09 Deleted XREF EC:6.3.5.-
2001-03-30 Added XREF EC:6.3.5.-

Other

Timestamp Action Category Detail
2003-01-11 Added SECONDARY GO:0016003 (glutamine amidotransferase)
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