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GO:0016874 ligase activity

Term Information

ID GO:0016874
Name ligase activity
Ontology Molecular Function
Definition Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GONUTS GO:0016874 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact synthetase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_generic149
goslim_candida89
goslim_pir462
goslim_yeast169
goslim_aspergillus85

Cross-references

Database ID
EC 6
InterPro IPR000022
InterPro IPR004101
InterPro IPR004524
InterPro IPR004549
InterPro IPR005482
InterPro IPR005930
InterPro IPR006075
InterPro IPR011762
InterPro IPR011763
InterPro IPR011764
InterPro IPR011810
InterPro IPR012647
InterPro IPR014042
InterPro IPR030297
UniProtKB-KW Ligase

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016874:
Relationship To GO:0016874 Child Term Child Term Name
Is a GO:0016877 ligase activity, forming carbon-sulfur bonds
Is a GO:0016879 ligase activity, forming carbon-nitrogen bonds
Is a GO:0016885 ligase activity, forming carbon-carbon bonds
Is a GO:0016886 ligase activity, forming phosphoric ester bonds
Is a GO:0051002 ligase activity, forming nitrogen-metal bonds
Is a GO:0008754 O antigen ligase activity
Is a GO:0045438 delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity
Is a GO:0003833 beta-alanyl-dopamine synthase activity
Is a GO:0016875 ligase activity, forming carbon-oxygen bonds
Regulates GO:0051340 regulation of ligase activity
Positively regulates GO:0051351 positive regulation of ligase activity
Negatively regulates GO:0051352 negative regulation of ligase activity
Regulates GO:0055103 ligase regulator activity
Negatively regulates GO:0055104 ligase inhibitor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016874. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016874 based on the entire annotation set Co-occurrence statistics for GO:0016874 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-12-14 Added SYNONYM synthetase activity
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2010-10-24 Deleted DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2010-10-24 Added DEFINITION Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2008-05-12 Deleted DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)
2006-02-09 Deleted XREF EC:6.-.-.-
2006-02-09 Added XREF EC:6
2004-09-29 Updated TERM ligase activity
2003-03-26 Updated DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2003-03-19 Updated TERM ligase activity
2002-11-27 Added DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2002-02-06 Updated TERM ligase
2001-04-03 Updated TERM ligase
2001-03-30 Added XREF EC:6.-.-.-
2001-03-30 Added TERM ligase

Term

Timestamp Action Category Detail
2004-09-29 Updated TERM ligase activity
2003-03-19 Updated TERM ligase activity
2002-02-06 Updated TERM ligase
2001-04-03 Updated TERM ligase
2001-03-30 Added TERM ligase

Definition/synonyms

Timestamp Action Category Detail
2012-12-14 Added SYNONYM synthetase activity
2010-10-24 Deleted DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2010-10-24 Added DEFINITION Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
2008-05-13 Added DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2008-05-12 Deleted DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2003-03-26 Updated DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
2002-11-27 Added DEFINITION Catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Deleted XREF EC:6.-.-.-
2006-02-09 Added XREF EC:6
2001-03-30 Added XREF EC:6.-.-.-

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_candida
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