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GO:0016829 lyase activity

Term Information

ID GO:0016829
Name lyase activity
Ontology Molecular Function
Definition Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Comment Note that enzymes of class EC:4.99.-.- should also be annotated to this term.
GONUTS GO:0016829 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow other lyase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_generic149
goslim_candida89
goslim_pir462
goslim_yeast169
goslim_aspergillus85

Cross-references

Database ID
EC 4
InterPro IPR000887
InterPro IPR001597
InterPro IPR001906
InterPro IPR002220
InterPro IPR002915
InterPro IPR003159
InterPro IPR004103
InterPro IPR004646
InterPro IPR005630
InterPro IPR005661
InterPro IPR008397
InterPro IPR010306
InterPro IPR017283
InterPro IPR018951
InterPro IPR020624
InterPro IPR020625
UniProtKB-KW Lyase

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0016850 other lyase activity CONSIDER GO:0016829

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016829:
Relationship To GO:0016829 Child Term Child Term Name
Is a GO:0004325 ferrochelatase activity
Is a GO:0016852 sirohydrochlorin cobaltochelatase activity
Is a GO:0018835 carbon phosphorus lyase activity
Is a GO:0018836 alkylmercury lyase activity
Is a GO:0047720 indoleacetaldoxime dehydratase activity
Is a GO:0016830 carbon-carbon lyase activity
Is a GO:0016835 carbon-oxygen lyase activity
Is a GO:0016840 carbon-nitrogen lyase activity
Is a GO:0016846 carbon-sulfur lyase activity
Is a GO:0016848 carbon-halide lyase activity
Is a GO:0016849 phosphorus-oxygen lyase activity
Is a GO:0043729 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
Regulates GO:0051339 regulation of lyase activity
Positively regulates GO:0051349 positive regulation of lyase activity
Negatively regulates GO:0051350 negative regulation of lyase activity
Is a GO:0043779 cobalt-precorrin-5A acetaldehyde-lyase activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016829. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016829 based on the entire annotation set Co-occurrence statistics for GO:0016829 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2008-05-12 Deleted DEFINITION Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)
2007-08-09 Added SYNONYM other lyase activity
2007-08-09 Deleted SYNONYM other lyase activity
2006-02-09 Deleted XREF EC:4.-.-.-
2006-02-09 Added XREF EC:4
2005-08-10 Added SYNONYM other lyase activity
2004-09-29 Updated TERM lyase activity
2003-08-06 Updated DEFINITION Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2003-03-26 Updated DEFINITION Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2003-03-19 Updated TERM lyase activity
2002-11-27 Added DEFINITION Catalysis of the nonhydrolytic removal of a group from a substrate with the resulting formation of a double bond. The reverse reaction is performed by a synthetase. Lyase is the systematic name for any enzyme of EC class 4.
2002-02-06 Updated TERM lyase
2001-04-03 Updated TERM lyase
2001-03-30 Added XREF EC:4.-.-.-
2001-03-30 Added TERM lyase

Term

Timestamp Action Category Detail
2004-09-29 Updated TERM lyase activity
2003-03-19 Updated TERM lyase activity
2002-02-06 Updated TERM lyase
2001-04-03 Updated TERM lyase
2001-03-30 Added TERM lyase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2008-05-12 Deleted DEFINITION Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2007-08-09 Added SYNONYM other lyase activity
2007-08-09 Deleted SYNONYM other lyase activity
2005-08-10 Added SYNONYM other lyase activity
2003-08-06 Updated DEFINITION Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2003-03-26 Updated DEFINITION Lyases are enzymes cleaving C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
2002-11-27 Added DEFINITION Catalysis of the nonhydrolytic removal of a group from a substrate with the resulting formation of a double bond. The reverse reaction is performed by a synthetase. Lyase is the systematic name for any enzyme of EC class 4.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Deleted XREF EC:4.-.-.-
2006-02-09 Added XREF EC:4
2001-03-30 Added XREF EC:4.-.-.-

Other

Timestamp Action Category Detail
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_generic
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2012-02-10 Added SLIM goslim_generic
2011-11-05 Added SLIM goslim_aspergillus
2011-03-18 Deleted SLIM goslim_goa
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_candida
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