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GO:0016829 lyase activity

Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

Term Information

ID GO:0016829
Name lyase activity
Ontology Molecular Function
Definition Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Comment Note that enzymes of class EC:4.99.-.- should also be annotated to this term.

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_candida91
goslim_goa62
goslim_pir470
goslim_yeast93

Synonyms

Type Synonym
narrow other lyase activity

Cross-references associated with this term:

Database ID
INTERPRO IPR003159
INTERPRO IPR002220
INTERPRO IPR005661
INTERPRO IPR001906
INTERPRO IPR002915
INTERPRO IPR001597
INTERPRO IPR004646
EC 4
INTERPRO IPR004103
INTERPRO IPR018951
INTERPRO IPR002762
INTERPRO IPR005630

This term can be used instead of these obsolete terms:

GO:0016850 other lyase activity (consider GO:0016829)

Web service: term information

Use this URI template to access this data as a service:

GTerm?id=termID&format=format

Full details can be found on the QuickGO Web Services page.

Ancestor Chart

Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term. Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms by one or more 'relationships'

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Chart

Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016829 lyase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0009985 dihydroflavonol(thiole) lyase activity
I GO:0004325 ferrochelatase activity
I GO:0016852 sirohydrochlorin cobaltochelatase activity
I GO:0018835 carbon phosphorus lyase activity
I GO:0018836 alkylmercury lyase activity
I GO:0047720 indoleacetaldoxime dehydratase activity
I GO:0016830 carbon-carbon lyase activity
I GO:0016835 carbon-oxygen lyase activity
I GO:0016840 carbon-nitrogen lyase activity
I GO:0016846 carbon-sulfur lyase activity
I GO:0016848 carbon-halide lyase activity
I GO:0016849 phosphorus-oxygen lyase activity
I GO:0043729 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
I GO:0043779 cobalt-precorrin-5A acetaldehyde-lyase activity
I GO:0046567 aphidicolan-16 beta-ol synthase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods. Users can decide which evidence code type should be used in the calculation of the co-occurence statistics.
Click on the 'Update' button to run the co-occurence calculation
IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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