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GO:0016790 thiolester hydrolase activityCatalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
Term Information
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| Type | Synonym |
| exact | thiolesterase activity |
| Database | ID |
| INTERPRO | IPR014166 |
| EC | 3.1.2 |
| INTERPRO | IPR016662 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||
![]() | GO:0003824 catalytic activity | |||
![]() | ![]() | GO:0016787 hydrolase activity | ||
![]() | ![]() | ![]() | GO:0016788 hydrolase activity, acting on ester bonds | |
![]() | ![]() | ![]() | ![]() | GO:0016790 thiolester hydrolase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0047951 glutathione thiolesterase activity |
| I | GO:0018738 S-formylglutathione hydrolase activity |
| I | GO:0004221 ubiquitin thiolesterase activity |
| I | GO:0004416 hydroxyacylglutathione hydrolase activity |
| I | GO:0050273 S-succinylglutathione hydrolase activity |
| I | GO:0047778 [citrate-(pro-3S)-lyase] thiolesterase activity |
| I | GO:0008474 palmitoyl-(protein) hydrolase activity |
| I | GO:0016289 CoA hydrolase activity |
| I | GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity |
| I | GO:0034946 3-isopropylbut-3-enoyl-CoA thioesterase activity |
| I | GO:0034843 2-oxoglutaryl-CoA thioesterase activity |
| I | GO:0034869 2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-12-11-04-06-50 |