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GO:0016787 hydrolase activity

Term Information

ID GO:0016787
Name hydrolase activity
Ontology Molecular Function
Definition Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
GONUTS GO:0016787 Wiki Page

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_metagenomics119
goslim_candida89
goslim_pir462
goslim_plant100
goslim_yeast169
goslim_aspergillus85

Cross-references

Database ID
EC 3
InterPro IPR000086
InterPro IPR000150
InterPro IPR000246
InterPro IPR000383
InterPro IPR000407
InterPro IPR000587
InterPro IPR000675
InterPro IPR001604
InterPro IPR002125
InterPro IPR002168
InterPro IPR002527
InterPro IPR002637
InterPro IPR002692
InterPro IPR002821
InterPro IPR002828
InterPro IPR002918
InterPro IPR002925
InterPro IPR002933
InterPro IPR003140
InterPro IPR003300
InterPro IPR004843
InterPro IPR005674
InterPro IPR005937
InterPro IPR005938
InterPro IPR005939
InterPro IPR006179
InterPro IPR006186
InterPro IPR006439
InterPro IPR006680
InterPro IPR006684
InterPro IPR006935
InterPro IPR007597
InterPro IPR007722
InterPro IPR008180
InterPro IPR008272
InterPro IPR008334
InterPro IPR008594
InterPro IPR010662
InterPro IPR011105
InterPro IPR011145
InterPro IPR011697
InterPro IPR011811
InterPro IPR011950
InterPro IPR011951
InterPro IPR013094
InterPro IPR013338
InterPro IPR013831
InterPro IPR014017
InterPro IPR015311
InterPro IPR015375
InterPro IPR015376
InterPro IPR015797
InterPro IPR016192
InterPro IPR017439
InterPro IPR017875
InterPro IPR018524
InterPro IPR020084
InterPro IPR020821
InterPro IPR021930
InterPro IPR022975
InterPro IPR023757
InterPro IPR023791
UniProtKB-KW Hydrolase

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016787:
Relationship To GO:0016787 Child Term Child Term Name
Is a GO:0051747 cytosine C-5 DNA demethylase activity
Is a GO:0003923 GPI-anchor transamidase activity
Is a GO:0008233 peptidase activity
Is a GO:0031964 beta-alanyl-histamine hydrolase activity
Is a GO:0003832 beta-alanyl-dopamine hydrolase activity
Is a GO:0019213 deacetylase activity
Is a GO:0017171 serine hydrolase activity
Is a GO:0046508 hydrolase activity, acting on carbon-sulfur bonds
Is a GO:0016788 hydrolase activity, acting on ester bonds
Is a GO:0016798 hydrolase activity, acting on glycosyl bonds
Is a GO:0016801 hydrolase activity, acting on ether bonds
Is a GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Is a GO:0016817 hydrolase activity, acting on acid anhydrides
Is a GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds
Is a GO:0016824 hydrolase activity, acting on acid halide bonds
Is a GO:0016825 hydrolase activity, acting on acid phosphorus-nitrogen bonds
Is a GO:0016826 hydrolase activity, acting on acid sulfur-nitrogen bonds
Is a GO:0016827 hydrolase activity, acting on acid carbon-phosphorus bonds
Is a GO:0016828 hydrolase activity, acting on acid sulfur-sulfur bonds
Regulates GO:0051336 regulation of hydrolase activity
Positively regulates GO:0051345 positive regulation of hydrolase activity
Negatively regulates GO:0051346 negative regulation of hydrolase activity
Is a GO:0036459 ubiquitinyl hydrolase activity
Is a GO:0052770 coenzyme F390-A hydrolase activity
Is a GO:0052771 coenzyme F390-G hydrolase activity
Is a GO:0098599 palmitoyl hydrolase activity

Protein Annotation

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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
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Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016787. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016787 based on the entire annotation set Co-occurrence statistics for GO:0016787 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-08-02 Added SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2011-11-05 Added SLIM goslim_aspergillus
2011-08-14 Deleted SLIM goslim_yeast
2011-03-18 Deleted SLIM goslim_goa
2010-12-05 Deleted SLIM goslim_generic
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)
2006-02-09 Added XREF EC:3
2006-02-09 Deleted XREF EC:3.-.-.-
2004-09-29 Updated TERM hydrolase activity
2004-03-13 Updated DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2003-10-18 Updated DEFINITION Catalysis of the hydrolysis of various bonds, eg. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2003-04-24 Updated DEFINITION Catalysis of the hydrolysis of various bonds, e. g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2003-03-19 Updated TERM hydrolase activity
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2002-02-06 Updated TERM hydrolase
2001-04-03 Updated TERM hydrolase
2001-03-30 Added XREF EC:3.-.-.-
2001-03-30 Added TERM hydrolase

Term

Timestamp Action Category Detail
2004-09-29 Updated TERM hydrolase activity
2003-03-19 Updated TERM hydrolase activity
2002-02-06 Updated TERM hydrolase
2001-04-03 Updated TERM hydrolase
2001-03-30 Added TERM hydrolase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2004-03-13 Updated DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2003-10-18 Updated DEFINITION Catalysis of the hydrolysis of various bonds, eg. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2003-04-24 Updated DEFINITION Catalysis of the hydrolysis of various bonds, e. g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
2002-11-27 Added DEFINITION Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003824 (catalytic activity)

Cross-references

Timestamp Action Category Detail
2006-02-09 Added XREF EC:3
2006-02-09 Deleted XREF EC:3.-.-.-
2001-03-30 Added XREF EC:3.-.-.-

Other

Timestamp Action Category Detail
2014-08-02 Added SLIM goslim_yeast
2013-04-18 Updated SLIM goslim_aspergillus
2013-04-18 Updated SLIM goslim_plant
2013-04-18 Updated SLIM goslim_pir
2013-04-18 Updated SLIM goslim_candida
2013-04-18 Updated SLIM goslim_metagenomics
2012-02-17 Added SLIM goslim_metagenomics
2011-11-05 Added SLIM goslim_aspergillus
2011-08-14 Deleted SLIM goslim_yeast
2011-03-18 Deleted SLIM goslim_goa
2010-12-05 Deleted SLIM goslim_generic
2008-06-09 Added SLIM goslim_yeast
2008-06-09 Added SLIM goslim_plant
2008-06-09 Added SLIM goslim_pir
2008-06-09 Added SLIM goslim_goa
2008-06-09 Added SLIM goslim_generic
2008-06-09 Added SLIM goslim_candida
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