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GO:0016581 NuRD complex

Term Information

ID GO:0016581
Name NuRD complex
Ontology Cellular Component
Definition An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
PMID:10589671 PMID:11743021 PMID:17289569
GONUTS GO:0016581 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact nucleosome remodeling and histone deacetylation complex
exact NRD complex
exact Mi-2 complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0005623 cell only_in_taxon 131567 cellular organisms
GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR028722
InterPro IPR028725

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016581:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016581. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016581 based on the entire annotation set Co-occurrence statistics for GO:0016581 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-05-11 Added RELATION is a GO:0090568 (nuclear transcriptional repressor complex)
2014-05-11 Deleted RELATION is a GO:0017053 (transcriptional repressor complex)
2013-02-17 Added RELATION is a GO:0090545 (CHD-type complex)
2009-07-23 Deleted SYNONYM SHREC complex
2008-12-01 Added RELATION is a GO:0017053 (transcriptional repressor complex)
2008-05-13 Added DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2008-05-12 Deleted DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2008-04-01 Updated RELATION is a GO:0000118 (histone deacetylase complex)
2007-08-09 Added SYNONYM Mi-2 complex
2007-08-09 Added SYNONYM NRD complex
2007-08-09 Added SYNONYM SHREC complex
2007-08-09 Added SYNONYM nucleosome remodeling and histone deacetylation complex
2007-08-09 Deleted SYNONYM SHREC complex
2007-08-09 Deleted SYNONYM Mi-2 complex
2007-08-09 Deleted SYNONYM NRD complex
2007-08-09 Deleted SYNONYM nucleosome remodeling and histone deacetylation complex
2007-05-27 Updated DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2007-05-05 Added SYNONYM SHREC complex
2004-05-29 Added SYNONYM nucleosome remodeling and histone deacetylation complex
2004-05-28 Added DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in both vertebrates and invertebrates. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2004-04-19 Added SYNONYM Mi-2 complex
2004-04-19 Added SYNONYM NRD complex
2004-04-16 Deleted SYNONYM Mi-2 complex
2004-04-16 Deleted SYNONYM NRD complex
2002-02-06 Updated TERM NuRD complex
2001-04-03 Updated TERM NuRD complex
2001-03-30 Added SYNONYM Mi-2 complex
2001-03-30 Added SYNONYM NRD complex
2001-03-30 Added TERM NuRD complex

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM NuRD complex
2001-04-03 Updated TERM NuRD complex
2001-03-30 Added TERM NuRD complex

Definition/synonyms

Timestamp Action Category Detail
2009-07-23 Deleted SYNONYM SHREC complex
2008-05-13 Added DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2008-05-12 Deleted DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2007-08-09 Added SYNONYM Mi-2 complex
2007-08-09 Added SYNONYM NRD complex
2007-08-09 Added SYNONYM SHREC complex
2007-08-09 Added SYNONYM nucleosome remodeling and histone deacetylation complex
2007-08-09 Deleted SYNONYM SHREC complex
2007-08-09 Deleted SYNONYM Mi-2 complex
2007-08-09 Deleted SYNONYM NRD complex
2007-08-09 Deleted SYNONYM nucleosome remodeling and histone deacetylation complex
2007-05-27 Updated DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2007-05-05 Added SYNONYM SHREC complex
2004-05-29 Added SYNONYM nucleosome remodeling and histone deacetylation complex
2004-05-28 Added DEFINITION An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in both vertebrates and invertebrates. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.
2004-04-19 Added SYNONYM Mi-2 complex
2004-04-19 Added SYNONYM NRD complex
2004-04-16 Deleted SYNONYM Mi-2 complex
2004-04-16 Deleted SYNONYM NRD complex
2001-03-30 Added SYNONYM Mi-2 complex
2001-03-30 Added SYNONYM NRD complex

Relationships

Timestamp Action Category Detail
2014-05-11 Added RELATION is a GO:0090568 (nuclear transcriptional repressor complex)
2014-05-11 Deleted RELATION is a GO:0017053 (transcriptional repressor complex)
2013-02-17 Added RELATION is a GO:0090545 (CHD-type complex)
2008-12-01 Added RELATION is a GO:0017053 (transcriptional repressor complex)
2008-04-01 Updated RELATION is a GO:0000118 (histone deacetylase complex)
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