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GO:0016446 somatic hypermutation of immunoglobulin genes

Term Information

ID GO:0016446
Name somatic hypermutation of immunoglobulin genes
Ontology Biological Process
Definition Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
PMID:11205330 PMID:11205333 PMID:14975236 PMID:7813007
GONUTS GO:0016446 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact somatic hypermutation of antibody genes

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000299 GO:0032501 multicellular organismal process only_in_taxon 2759 Eukaryota
GOTAX:0000537 GO:0032501 multicellular organismal process never_in_taxon 4932 Saccharomyces cerevisiae
GOTAX:0000538 GO:0032501 multicellular organismal process never_in_taxon 4896 Schizosaccharomyces pombe
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016446:
Relationship To GO:0016446 Child Term Child Term Name
Is a GO:0002205 somatic hypermutation of immunoglobulin genes involved in immune response

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016446. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016446 based on the entire annotation set Co-occurrence statistics for GO:0016446 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Added RELATION is a GO:0016445 (somatic diversification of immunoglobulins)
2010-10-11 Deleted RELATION is a GO:0002208 (somatic diversification of immunoglobulins involved in immune response)
2010-10-01 Added RELATION is a GO:0002208 (somatic diversification of immunoglobulins involved in immune response)
2010-10-01 Deleted RELATION is a GO:0016445 (somatic diversification of immunoglobulins)
2008-05-13 Added DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2008-05-12 Deleted DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2008-04-01 Updated RELATION is a GO:0016445 (somatic diversification of immunoglobulins)
2008-04-01 Updated RELATION is a GO:0002566 (somatic diversification of immune receptors via somatic mutation)
2007-08-09 Added SYNONYM somatic hypermutation of antibody genes
2007-08-09 Deleted SYNONYM somatic hypermutation of antibody genes
2006-09-21 Added SYNONYM somatic hypermutation of antibody genes
2006-09-21 Updated TERM somatic hypermutation of immunoglobulin genes
2006-09-19 Updated DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2005-05-26 Updated DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occurring somatically, during the affinity maturation of B cells as they migrate into the germinal centers.
2002-11-27 Updated DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occurring somatically, during the affinity maturation of B-cells as they migrate into the germinal centers.
2002-02-06 Updated TERM somatic hypermutation of antibody genes
2001-08-06 Added DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occuring somatically, during the affinity maturation of B cells as they migrate into the germinal centers.
2001-04-03 Updated TERM somatic hypermutation of antibody genes
2001-03-30 Added TERM somatic hypermutation of antibody genes

Term

Timestamp Action Category Detail
2006-09-21 Updated TERM somatic hypermutation of immunoglobulin genes
2002-02-06 Updated TERM somatic hypermutation of antibody genes
2001-04-03 Updated TERM somatic hypermutation of antibody genes
2001-03-30 Added TERM somatic hypermutation of antibody genes

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2008-05-12 Deleted DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2007-08-09 Added SYNONYM somatic hypermutation of antibody genes
2007-08-09 Deleted SYNONYM somatic hypermutation of antibody genes
2006-09-21 Added SYNONYM somatic hypermutation of antibody genes
2006-09-19 Updated DEFINITION Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.
2005-05-26 Updated DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occurring somatically, during the affinity maturation of B cells as they migrate into the germinal centers.
2002-11-27 Updated DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occurring somatically, during the affinity maturation of B-cells as they migrate into the germinal centers.
2001-08-06 Added DEFINITION Mutations that result in amino acid changes in the rearranged V regions of antibodies occuring somatically, during the affinity maturation of B cells as they migrate into the germinal centers.

Relationships

Timestamp Action Category Detail
2010-10-11 Added RELATION is a GO:0016445 (somatic diversification of immunoglobulins)
2010-10-11 Deleted RELATION is a GO:0002208 (somatic diversification of immunoglobulins involved in immune response)
2010-10-01 Added RELATION is a GO:0002208 (somatic diversification of immunoglobulins involved in immune response)
2010-10-01 Deleted RELATION is a GO:0016445 (somatic diversification of immunoglobulins)
2008-04-01 Updated RELATION is a GO:0016445 (somatic diversification of immunoglobulins)
2008-04-01 Updated RELATION is a GO:0002566 (somatic diversification of immune receptors via somatic mutation)
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