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GO:0016303 1-phosphatidylinositol-3-kinase activity

Term Information

ID GO:0016303
Name 1-phosphatidylinositol-3-kinase activity
Ontology Molecular Function
Definition Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
Secondary IDs GO:0004429
GONUTS GO:0016303 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact PtdIns-3-kinase activity
exact PI3-kinase activity
narrow type I phosphatidylinositol kinase activity
narrow type III phosphoinositide 3-kinase activity
related Vps34p
exact PI3K
exact 1-phosphatidylinositol 3-kinase activity
exact ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity
narrow phosphatidylinositol 3-kinase, class I, catalyst activity
narrow phosphatidylinositol 3-kinase activity, class III
narrow phosphatidylinositol 3-kinase activity, class II
narrow phosphatidylinositol 3-kinase activity, class I

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.7.1.137
InterPro IPR008290
KEGG R03362
MetaCyc 1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
RHEA 12712

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0016305 phosphatidylinositol 3-kinase activity, class II CONSIDER GO:0016303
GO:0015072 phosphatidylinositol 3-kinase, class I, catalyst activity REPLACEDBY GO:0016303
GO:0016304 phosphatidylinositol 3-kinase activity, class I REPLACEDBY GO:0016303
GO:0016306 phosphatidylinositol 3-kinase activity, class III REPLACEDBY GO:0016303

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016303:
Relationship To GO:0016303 Child Term Child Term Name
Regulates GO:0046935 1-phosphatidylinositol-3-kinase regulator activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016303. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016303 based on the entire annotation set Co-occurrence statistics for GO:0016303 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-01-15 Added RELATION part of GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
2012-01-15 Added RELATION is a GO:0035004 (phosphatidylinositol 3-kinase activity)
2012-01-08 Added RELATION is a GO:0052742 (phosphatidylinositol kinase activity)
2012-01-08 Deleted RELATION is a GO:0035004 (phosphatidylinositol 3-kinase activity)
2011-01-30 Deleted SYNONYM phosphatidylinositol 3-kinase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2010-10-11 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
2010-10-11 Added XREF RHEA:12712
2010-10-11 Added XREF KEGG:R03362
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2008-04-01 Updated RELATION is a GO:0035004 (phosphatidylinositol 3-kinase activity)
2007-12-14 Added SYNONYM ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity
2007-12-14 Added SYNONYM Vps34p
2007-09-06 Added SYNONYM PI3-kinase activity
2007-09-06 Added SYNONYM PtdIns-3-kinase activity
2007-09-06 Added SYNONYM type I phosphatidylinositol kinase activity
2007-09-06 Added SYNONYM type III phosphoinositide 3-kinase activity
2007-08-09 Added SYNONYM 1-phosphatidylinositol 3-kinase activity
2007-08-09 Added SYNONYM PI3K
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity, class I
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity, class II
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity, class III
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase, class I, catalyst activity
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity
2007-08-09 Deleted SYNONYM 1-phosphatidylinositol 3-kinase activity
2007-08-09 Deleted SYNONYM PI3K
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity, class I
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity, class II
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity, class III
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase, class I, catalyst activity
2007-04-01 Updated TERM 1-phosphatidylinositol-3-kinase activity
2007-04-01 Added SYNONYM phosphatidylinositol 3-kinase activity
2005-09-02 Added SECONDARY GO:0004429 (1-phosphatidylinositol 3-kinase)
2005-09-02 Deleted SYNONYM 1-phosphatidylinositol 3-kinase
2005-09-02 Added SYNONYM 1-phosphatidylinositol 3-kinase activity
2005-08-10 Added SYNONYM 1-phosphatidylinositol 3-kinase
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase activity, class I
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase activity, class II
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase activity, class III
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase, class I, catalyst activity
2004-04-19 Added SYNONYM PI3K
2004-04-16 Deleted SYNONYM PI3K
2003-10-27 Added SYNONYM PI3K
2003-10-27 Added XREF MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
2003-08-21 Deleted SYNONYM PI3K
2003-05-08 Updated DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. A phosphoinositide kinase which phosphorylates the carbon-3 residue of the inositol ring of myo-inositol or a phosphoinositol.
2003-03-19 Updated TERM phosphatidylinositol 3-kinase activity
2002-02-06 Updated TERM phosphatidylinositol 3-kinase
2001-08-06 Added DEFINITION A phosphoinositide kinase which phosphorylates the carbon-3 residue of the inositol ring of myo-inositol or a phosphoinositol.
2001-04-03 Updated TERM phosphatidylinositol 3-kinase
2001-03-30 Added XREF EC:2.7.1.137
2001-03-30 Added SYNONYM PI3K
2001-03-30 Added TERM phosphatidylinositol 3-kinase

Term

Timestamp Action Category Detail
2007-04-01 Updated TERM 1-phosphatidylinositol-3-kinase activity
2003-03-19 Updated TERM phosphatidylinositol 3-kinase activity
2002-02-06 Updated TERM phosphatidylinositol 3-kinase
2001-04-03 Updated TERM phosphatidylinositol 3-kinase
2001-03-30 Added TERM phosphatidylinositol 3-kinase

Definition/synonyms

Timestamp Action Category Detail
2011-01-30 Deleted SYNONYM phosphatidylinositol 3-kinase activity
2010-10-11 Deleted DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2010-10-11 Added DEFINITION Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2007-12-14 Added SYNONYM ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity
2007-12-14 Added SYNONYM Vps34p
2007-09-06 Added SYNONYM PI3-kinase activity
2007-09-06 Added SYNONYM PtdIns-3-kinase activity
2007-09-06 Added SYNONYM type I phosphatidylinositol kinase activity
2007-09-06 Added SYNONYM type III phosphoinositide 3-kinase activity
2007-08-09 Added SYNONYM 1-phosphatidylinositol 3-kinase activity
2007-08-09 Added SYNONYM PI3K
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity, class I
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity, class II
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase activity, class III
2007-08-09 Added SYNONYM phosphatidylinositol 3-kinase, class I, catalyst activity
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity
2007-08-09 Deleted SYNONYM 1-phosphatidylinositol 3-kinase activity
2007-08-09 Deleted SYNONYM PI3K
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity, class I
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity, class II
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase activity, class III
2007-08-09 Deleted SYNONYM phosphatidylinositol 3-kinase, class I, catalyst activity
2007-04-01 Added SYNONYM phosphatidylinositol 3-kinase activity
2005-09-02 Deleted SYNONYM 1-phosphatidylinositol 3-kinase
2005-09-02 Added SYNONYM 1-phosphatidylinositol 3-kinase activity
2005-08-10 Added SYNONYM 1-phosphatidylinositol 3-kinase
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase activity, class I
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase activity, class II
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase activity, class III
2005-08-10 Added SYNONYM phosphatidylinositol 3-kinase, class I, catalyst activity
2004-04-19 Added SYNONYM PI3K
2004-04-16 Deleted SYNONYM PI3K
2003-10-27 Added SYNONYM PI3K
2003-08-21 Deleted SYNONYM PI3K
2003-05-08 Updated DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. A phosphoinositide kinase which phosphorylates the carbon-3 residue of the inositol ring of myo-inositol or a phosphoinositol.
2001-08-06 Added DEFINITION A phosphoinositide kinase which phosphorylates the carbon-3 residue of the inositol ring of myo-inositol or a phosphoinositol.
2001-03-30 Added SYNONYM PI3K

Relationships

Timestamp Action Category Detail
2012-01-15 Added RELATION part of GO:0036092 (phosphatidylinositol-3-phosphate biosynthetic process)
2012-01-15 Added RELATION is a GO:0035004 (phosphatidylinositol 3-kinase activity)
2012-01-08 Added RELATION is a GO:0052742 (phosphatidylinositol kinase activity)
2012-01-08 Deleted RELATION is a GO:0035004 (phosphatidylinositol 3-kinase activity)
2008-04-01 Updated RELATION is a GO:0035004 (phosphatidylinositol 3-kinase activity)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:12712
2010-10-11 Added XREF KEGG:R03362
2003-10-27 Added XREF MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN
2001-03-30 Added XREF EC:2.7.1.137

Other

Timestamp Action Category Detail
2005-09-02 Added SECONDARY GO:0004429 (1-phosphatidylinositol 3-kinase)
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