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GO:0016272 prefoldin complex

Term Information

ID GO:0016272
Name prefoldin complex
Ontology Cellular Component
Definition A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
PMID:17384227 PMID:24068951 PMID:9630229
GONUTS GO:0016272 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow GIM complex

Protein complexes

Database ID Name
IntAct gimc_yeast Prefoldin complex

Cross-references

Database ID
InterPro IPR002777
InterPro IPR011599
InterPro IPR012713
InterPro IPR016655
InterPro IPR016661
InterPro IPR027235
Wikipedia Prefoldin

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016272:
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Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016272. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016272 based on the entire annotation set Co-occurrence statistics for GO:0016272 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-07 Added DEFINITION A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
2013-12-07 Deleted DEFINITION A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
2013-11-06 Deleted DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2013-11-06 Added DEFINITION A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
2013-11-06 Deleted RELATION is a GO:0044445 (cytosolic part)
2009-11-27 Added XREF Wikipedia:Prefoldin
2008-05-13 Added DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2008-05-12 Deleted DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2007-08-09 Added SYNONYM GIM complex
2007-08-09 Deleted SYNONYM GIM complex
2004-04-19 Added SYNONYM GIM complex
2004-04-16 Deleted SYNONYM GIM complex
2003-04-24 Updated DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2003-04-16 Added SYNONYM GIM complex
2003-03-26 Added DEFINITION A multi-subunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2002-12-17 Updated TERM prefoldin complex
2002-02-06 Updated TERM prefoldin
2001-04-03 Updated TERM prefoldin
2001-03-30 Added TERM prefoldin

Term

Timestamp Action Category Detail
2002-12-17 Updated TERM prefoldin complex
2002-02-06 Updated TERM prefoldin
2001-04-03 Updated TERM prefoldin
2001-03-30 Added TERM prefoldin

Definition/synonyms

Timestamp Action Category Detail
2013-12-07 Added DEFINITION A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
2013-12-07 Deleted DEFINITION A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
2013-11-06 Deleted DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2013-11-06 Added DEFINITION A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
2008-05-13 Added DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2008-05-12 Deleted DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2007-08-09 Added SYNONYM GIM complex
2007-08-09 Deleted SYNONYM GIM complex
2004-04-19 Added SYNONYM GIM complex
2004-04-16 Deleted SYNONYM GIM complex
2003-04-24 Updated DEFINITION A multisubunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.
2003-04-16 Added SYNONYM GIM complex
2003-03-26 Added DEFINITION A multi-subunit chaperone that acts to delivers unfolded proteins to cytosolic chaperonin. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits.

Relationships

Timestamp Action Category Detail
2013-11-06 Deleted RELATION is a GO:0044445 (cytosolic part)
2008-04-01 Updated RELATION is a GO:0044445 (cytosolic part)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)

Cross-references

Timestamp Action Category Detail
2009-11-27 Added XREF Wikipedia:Prefoldin
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