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GO:0016246 RNA interference

Term Information

ID GO:0016246
Name RNA interference
Ontology Biological Process
Definition The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
PMID:11201747 PMID:11713190 PMID:18771919
Comment Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'.
GONUTS GO:0016246 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact posttranscriptional gene silencing by siRNA
exact RNAi

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0016246 RNA interference never_in_taxon 4895 Schizosaccharomyces
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR033759
Wikipedia RNA_interference

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0016246:
Relationship To GO:0016246 Child Term Child Term Name
Part of GO:0030422 production of siRNA involved in RNA interference
Part of GO:0030423 targeting of mRNA for destruction involved in RNA interference
Part of GO:0035087 siRNA loading onto RISC involved in RNA interference
Part of GO:0070549 negative regulation of translation involved in RNA interference
Part of GO:0010599 production of lsiRNA involved in RNA interference
Part of GO:0090625 mRNA cleavage involved in gene silencing by siRNA
Capable of part of GO:1990633 mutator focus
Is a GO:1903453 RNA interference involved in olfactory learning
Regulates GO:1900368 regulation of RNA interference
Negatively regulates GO:1900369 negative regulation of RNA interference
Positively regulates GO:1900370 positive regulation of RNA interference
Part of GO:0033168 conversion of ds siRNA to ss siRNA involved in RNA interference
Is a GO:0036453 transitive RNA interference

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0016246. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0016246 based on the entire annotation set Co-occurrence statistics for GO:0016246 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-12-01 Deleted DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2010-12-01 Added DEFINITION The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2009-09-13 Added SYNONYM posttranscriptional gene silencing by siRNA
2009-04-06 Deleted DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2009-04-06 Added DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2009-03-29 Added XREF Wikipedia:RNA_interference
2008-05-13 Added DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2008-05-12 Deleted DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2008-04-01 Updated RELATION is a GO:0035194 (posttranscriptional gene silencing by RNA)
2007-08-09 Added SYNONYM RNAi
2007-08-09 Deleted SYNONYM RNAi
2004-11-09 Updated DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2004-04-19 Added SYNONYM RNAi
2004-04-16 Deleted SYNONYM RNAi
2002-02-06 Updated TERM RNA interference
2001-08-06 Added DEFINITION The process by which double-stranded RNAs silence cognate genes.
2001-04-03 Updated TERM RNA interference
2001-03-30 Added SYNONYM RNAi
2001-03-30 Added TERM RNA interference

Term

Timestamp Action Category Detail
2002-02-06 Updated TERM RNA interference
2001-04-03 Updated TERM RNA interference
2001-03-30 Added TERM RNA interference

Definition/synonyms

Timestamp Action Category Detail
2010-12-01 Deleted DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2010-12-01 Added DEFINITION The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2009-09-13 Added SYNONYM posttranscriptional gene silencing by siRNA
2009-04-06 Deleted DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2009-04-06 Added DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes.
2008-05-13 Added DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2008-05-12 Deleted DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2007-08-09 Added SYNONYM RNAi
2007-08-09 Deleted SYNONYM RNAi
2004-11-09 Updated DEFINITION The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes.
2004-04-19 Added SYNONYM RNAi
2004-04-16 Deleted SYNONYM RNAi
2001-08-06 Added DEFINITION The process by which double-stranded RNAs silence cognate genes.
2001-03-30 Added SYNONYM RNAi

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0035194 (posttranscriptional gene silencing by RNA)

Cross-references

Timestamp Action Category Detail
2009-03-29 Added XREF Wikipedia:RNA_interference
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