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GO:0016236 macroautophagyThe major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.
Term Information
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| Type | Synonym |
| exact | non-specific autophagy |
| exact | autophagy in response to cellular starvation |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0008150 biological_process | |||||||||||||||||||
![]() | GO:0008152 metabolic process | ||||||||||||||||||
![]() | ![]() | GO:0009987 cellular process | |||||||||||||||||
![]() | ![]() | ![]() | GO:0050896 response to stimulus | ||||||||||||||||
![]() | ![]() | ![]() | ![]() | GO:0007154 cell communication | |||||||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0009056 catabolic process | ||||||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0006950 response to stress | |||||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0009605 response to external stimulus | ||||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0044237 cellular metabolic process | |||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0009991 response to extracellular stimulus | ||||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0051716 cellular response to stimulus | |||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0031667 response to nutrient levels | ||||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0033554 cellular response to stress | |||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0044248 cellular catabolic process | ||||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0006914 autophagy | |||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0042594 response to starvation | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0031668 cellular response to extracellular stimulus | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0031669 cellular response to nutrient levels | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0009267 cellular response to starvation | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016236 macroautophagy |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| P | GO:0000045 autophagic vacuole formation |
| P | GO:0000046 autophagic vacuole fusion |
| PR | GO:0016239 positive regulation of macroautophagy |
| R | GO:0016241 regulation of macroautophagy |
| NR | GO:0016242 negative regulation of macroautophagy |
| P | GO:0016240 autophagic vacuole docking |
| P | GO:0016243 regulation of autophagic vacuole size |
| P | GO:0030399 autophagic membrane disassembly |
| I | GO:0000423 macromitophagy |
| I | GO:0000425 macropexophagy |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-25-04-02-21 |