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GO:0016236 macroautophagy

The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.

Term Information

ID GO:0016236
Name macroautophagy
Ontology Biological Process
Definition The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded.
Comment

Synonyms

Type Synonym
exact non-specific autophagy
exact autophagy in response to cellular starvation

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009987 cellular process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0009056 catabolic process
GO:0006950 response to stress
GO:0009605 response to external stimulus
GO:0044237 cellular metabolic process
GO:0009991 response to extracellular stimulus
GO:0051716 cellular response to stimulus
GO:0031667 response to nutrient levels
GO:0033554 cellular response to stress
GO:0044248 cellular catabolic process
GO:0006914 autophagy
GO:0042594 response to starvation
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0009267 cellular response to starvation
GO:0016236 macroautophagy

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0000045 autophagic vacuole formation
P GO:0000046 autophagic vacuole fusion
PR GO:0016239 positive regulation of macroautophagy
R GO:0016241 regulation of macroautophagy
NR GO:0016242 negative regulation of macroautophagy
P GO:0016240 autophagic vacuole docking
P GO:0016243 regulation of autophagic vacuole size
P GO:0030399 autophagic membrane disassembly
I GO:0000423 macromitophagy
I GO:0000425 macropexophagy

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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