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GO:0005085 guanyl-nucleotide exchange factor activity

Term Information

ID GO:0005085
Name guanyl-nucleotide exchange factor activity
Ontology Molecular Function
Definition Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
Comment Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product.
Secondary IDs GO:0008433 GO:0016219 GO:0019839
GONUTS GO:0005085 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact guanyl-nucleotide release factor activity
exact guanyl-nucleotide releasing factor
exact GDP-dissociation stimulator activity
exact GDS
exact GEF
narrow GNRP

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Binding term considerationsLink
Describing enzyme functions that catalyse multi-stage reactionsLink

GO Slims

This term is present in the following GO Consortium-maintained GO slims:
GO slim nameCount of all terms
goslim_yeast169

Cross-references

Database ID
InterPro IPR000651
InterPro IPR001331
InterPro IPR001895
InterPro IPR005414
InterPro IPR007515
InterPro IPR008937
InterPro IPR016019
InterPro IPR019804
InterPro IPR026791
InterPro IPR026796
InterPro IPR026798
InterPro IPR026799
InterPro IPR026800
InterPro IPR026817
InterPro IPR028570
InterPro IPR029647
UniProtKB-KW Guanine-nucleotide releasing factor

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0005085:
Relationship To GO:0005085 Child Term Child Term Name
Is a GO:0017132 cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity
Is a GO:0005086 ARF guanyl-nucleotide exchange factor activity
Is a GO:0005088 Ras guanyl-nucleotide exchange factor activity
Is a GO:0005090 Sar guanyl-nucleotide exchange factor activity

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0005085. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0005085 based on the entire annotation set Co-occurrence statistics for GO:0005085 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-08-02 Added SLIM goslim_yeast
2014-06-11 Added RELATION part of GO:0043547 (positive regulation of GTPase activity)
2014-06-11 Deleted RELATION part of GO:0043087 (regulation of GTPase activity)
2013-11-15 Added RELATION part of GO:0043087 (regulation of GTPase activity)
2013-11-15 Added RELATION is a GO:0003674 (molecular_function)
2013-11-15 Deleted RELATION is a GO:0030695 (GTPase regulator activity)
2010-10-29 Added SYNONYM GDS
2010-10-29 Added RELATION negatively regulates GO:0019003 (GDP binding)
2010-10-29 Added SYNONYM GDP-dissociation stimulator activity
2010-10-29 Added SECONDARY GO:0016219 (GDP-dissociation stimulator activity)
2009-12-15 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2009-12-15 Added DEFINITION Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-13 Added DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-12 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-04-01 Updated RELATION is a GO:0030695 (GTPase regulator activity)
2007-08-09 Added SYNONYM GEF
2007-08-09 Added SYNONYM GNRP
2007-08-09 Added SYNONYM guanyl-nucleotide release factor activity
2007-08-09 Added SYNONYM guanyl-nucleotide releasing factor
2007-08-09 Deleted SYNONYM GEF
2007-08-09 Deleted SYNONYM GNRP
2007-08-09 Deleted SYNONYM guanyl-nucleotide release factor activity
2007-08-09 Deleted SYNONYM guanyl-nucleotide releasing factor
2006-04-14 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2004-04-19 Added SYNONYM guanyl-nucleotide releasing factor
2004-04-19 Added SYNONYM GNRP
2004-04-19 Added SYNONYM guanyl-nucleotide release factor activity
2004-04-19 Added SYNONYM GEF
2004-04-16 Deleted SYNONYM GEF
2004-04-16 Deleted SYNONYM GNRP
2004-04-16 Deleted SYNONYM guanyl-nucleotide release factor activity
2004-04-16 Deleted SYNONYM guanyl-nucleotide releasing factor
2003-05-28 Added SECONDARY GO:0019839 (guanyl-nucleotide release factor activity)
2003-05-28 Added SYNONYM guanyl-nucleotide release factor activity
2003-04-02 Added DEFINITION Stimulates the hydrolysis and exchange of guanyl nucleotides by other proteins.
2003-03-19 Updated TERM guanyl-nucleotide exchange factor activity
2002-02-06 Updated TERM guanyl-nucleotide exchange factor
2001-12-10 Added SECONDARY GO:0008433 (guanyl-nucleotide releasing factor)
2001-12-10 Added SYNONYM guanyl-nucleotide releasing factor
2001-12-10 Added SYNONYM GNRP
2001-04-03 Updated TERM guanyl-nucleotide exchange factor
2001-03-30 Added SYNONYM GEF
2001-03-30 Added TERM guanyl-nucleotide exchange factor

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM guanyl-nucleotide exchange factor activity
2002-02-06 Updated TERM guanyl-nucleotide exchange factor
2001-04-03 Updated TERM guanyl-nucleotide exchange factor
2001-03-30 Added TERM guanyl-nucleotide exchange factor

Definition/synonyms

Timestamp Action Category Detail
2010-10-29 Added SYNONYM GDS
2010-10-29 Added SYNONYM GDP-dissociation stimulator activity
2009-12-15 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2009-12-15 Added DEFINITION Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-13 Added DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2008-05-12 Deleted DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2007-08-09 Added SYNONYM GEF
2007-08-09 Added SYNONYM GNRP
2007-08-09 Added SYNONYM guanyl-nucleotide release factor activity
2007-08-09 Added SYNONYM guanyl-nucleotide releasing factor
2007-08-09 Deleted SYNONYM GEF
2007-08-09 Deleted SYNONYM GNRP
2007-08-09 Deleted SYNONYM guanyl-nucleotide release factor activity
2007-08-09 Deleted SYNONYM guanyl-nucleotide releasing factor
2006-04-14 Updated DEFINITION Stimulates the exchange of guanyl nucleotides by a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
2004-04-19 Added SYNONYM guanyl-nucleotide releasing factor
2004-04-19 Added SYNONYM GNRP
2004-04-19 Added SYNONYM guanyl-nucleotide release factor activity
2004-04-19 Added SYNONYM GEF
2004-04-16 Deleted SYNONYM GEF
2004-04-16 Deleted SYNONYM GNRP
2004-04-16 Deleted SYNONYM guanyl-nucleotide release factor activity
2004-04-16 Deleted SYNONYM guanyl-nucleotide releasing factor
2003-05-28 Added SYNONYM guanyl-nucleotide release factor activity
2003-04-02 Added DEFINITION Stimulates the hydrolysis and exchange of guanyl nucleotides by other proteins.
2001-12-10 Added SYNONYM guanyl-nucleotide releasing factor
2001-12-10 Added SYNONYM GNRP
2001-03-30 Added SYNONYM GEF

Relationships

Timestamp Action Category Detail
2014-06-11 Added RELATION part of GO:0043547 (positive regulation of GTPase activity)
2014-06-11 Deleted RELATION part of GO:0043087 (regulation of GTPase activity)
2013-11-15 Added RELATION part of GO:0043087 (regulation of GTPase activity)
2013-11-15 Added RELATION is a GO:0003674 (molecular_function)
2013-11-15 Deleted RELATION is a GO:0030695 (GTPase regulator activity)
2010-10-29 Added RELATION negatively regulates GO:0019003 (GDP binding)
2008-04-01 Updated RELATION is a GO:0030695 (GTPase regulator activity)

Other

Timestamp Action Category Detail
2014-08-02 Added SLIM goslim_yeast
2010-10-29 Added SECONDARY GO:0016219 (GDP-dissociation stimulator activity)
2003-05-28 Added SECONDARY GO:0019839 (guanyl-nucleotide release factor activity)
2001-12-10 Added SECONDARY GO:0008433 (guanyl-nucleotide releasing factor)
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