spacer

GO:0015057 thrombin-activated receptor activity

Term Information

ID GO:0015057
Name thrombin-activated receptor activity
Ontology Molecular Function
Definition A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
PMID:20423334
Secondary IDs GO:0010655
GONUTS GO:0015057 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact thrombin receptor activity, G-protein coupled
exact thrombin receptor activity

Cross-references

Database ID
InterPro IPR002281
InterPro IPR003912
InterPro IPR003943
InterPro IPR003944

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015057:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0015057. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0015057 based on the entire annotation set Co-occurrence statistics for GO:0015057 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-09-22 Added DEFINITION A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2016-09-22 Updated TERM thrombin-activated receptor activity
2016-09-22 Added SYNONYM thrombin receptor activity
2016-09-22 Deleted DEFINITION Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
2010-06-15 Added RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2010-06-08 Added RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2009-10-28 Deleted RELATION is a GO:0001653 (peptide receptor activity)
2009-10-27 Deleted DEFINITION Combining with thrombin to initiate a change in cell activity.
2009-10-27 Added DEFINITION Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
2009-10-27 Added SYNONYM thrombin receptor activity, G-protein coupled
2009-10-27 Added RELATION is a GO:0008528 (G-protein coupled peptide receptor activity)
2009-10-27 Added SECONDARY GO:0010655 (thrombin receptor activity, G-protein coupled)
2008-08-11 Added RELATION is a GO:0001653 (peptide receptor activity)
2008-08-11 Deleted RELATION is a GO:0008528 (G-protein coupled peptide receptor activity)
2008-05-13 Added DEFINITION Combining with thrombin to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with thrombin to initiate a change in cell activity.
2008-04-01 Updated RELATION is a GO:0008528 (G-protein coupled peptide receptor activity)
2004-01-03 Updated DEFINITION Combining with thrombin to initiate a change in cell activity.
2003-05-08 Added DEFINITION The function of combining with thrombin to initiate a change in cell function.
2003-03-19 Updated TERM thrombin receptor activity
2002-02-06 Updated TERM thrombin receptor
2001-04-03 Updated TERM thrombin receptor
2001-03-30 Added TERM thrombin receptor

Term

Timestamp Action Category Detail
2016-09-22 Updated TERM thrombin-activated receptor activity
2003-03-19 Updated TERM thrombin receptor activity
2002-02-06 Updated TERM thrombin receptor
2001-04-03 Updated TERM thrombin receptor
2001-03-30 Added TERM thrombin receptor

Definition/synonyms

Timestamp Action Category Detail
2016-09-22 Added DEFINITION A G-protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2016-09-22 Added SYNONYM thrombin receptor activity
2016-09-22 Deleted DEFINITION Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
2009-10-27 Deleted DEFINITION Combining with thrombin to initiate a change in cell activity.
2009-10-27 Added DEFINITION Combining with thrombin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
2009-10-27 Added SYNONYM thrombin receptor activity, G-protein coupled
2008-05-13 Added DEFINITION Combining with thrombin to initiate a change in cell activity.
2008-05-12 Deleted DEFINITION Combining with thrombin to initiate a change in cell activity.
2004-01-03 Updated DEFINITION Combining with thrombin to initiate a change in cell activity.
2003-05-08 Added DEFINITION The function of combining with thrombin to initiate a change in cell function.

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2010-06-14 Deleted RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2010-06-08 Added RELATION part of GO:0070493 (thrombin-activated receptor signaling pathway)
2009-10-28 Deleted RELATION is a GO:0001653 (peptide receptor activity)
2009-10-27 Added RELATION is a GO:0008528 (G-protein coupled peptide receptor activity)
2008-08-11 Added RELATION is a GO:0001653 (peptide receptor activity)
2008-08-11 Deleted RELATION is a GO:0008528 (G-protein coupled peptide receptor activity)
2008-04-01 Updated RELATION is a GO:0008528 (G-protein coupled peptide receptor activity)

Other

Timestamp Action Category Detail
2009-10-27 Added SECONDARY GO:0010655 (thrombin receptor activity, G-protein coupled)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
14ms