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GO:0015039 NADPH-adrenodoxin reductase activity

Term Information

ID GO:0015039
Name NADPH-adrenodoxin reductase activity
Ontology Molecular Function
Definition Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
Comment Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'.
GONUTS GO:0015039 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact NADPH:adrenodoxin oxidoreductase activity
broad adrenodoxin reductase activity
exact adrenodoxin-type ferredoxin reductase activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.18.1.6
MetaCyc RXN-13685

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015039:
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Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0015039. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0015039 based on the entire annotation set Co-occurrence statistics for GO:0015039 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2016-05-25 Added XREF MetaCyc:RXN-13685
2016-05-25 Added XREF EC:1.18.1.6
2016-05-25 Deleted XREF EC:1.18.1.-
2008-06-30 Added RELATION is a GO:0016491 (oxidoreductase activity)
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)
2007-12-08 Added SYNONYM adrenodoxin-type ferredoxin reductase activity
2007-12-08 Added SYNONYM NADPH:adrenodoxin oxidoreductase activity
2007-12-08 Added SYNONYM adrenodoxin reductase activity
2003-11-05 Added XREF EC:1.18.1.-
2003-11-05 Deleted XREF EC:1.18.1.2
2003-03-19 Updated TERM NADPH-adrenodoxin reductase activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
2002-02-06 Updated TERM NADPH-adrenodoxin reductase
2001-11-07 Updated TERM NADPH-adrenodoxin reductase
2001-08-06 Added DEFINITION An animal flavoenzyme that transfers electrons from NADPH to oxidised adrenodoxin, first enzymatic step in the mitochondrial P450 monooxygenase system.
2001-04-03 Updated TERM NADPH--adrenodoxin reductase
2001-03-30 Added XREF EC:1.18.1.2
2001-03-30 Added TERM NADPH--adrenodoxin reductase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM NADPH-adrenodoxin reductase activity
2002-02-06 Updated TERM NADPH-adrenodoxin reductase
2001-11-07 Updated TERM NADPH-adrenodoxin reductase
2001-04-03 Updated TERM NADPH--adrenodoxin reductase
2001-03-30 Added TERM NADPH--adrenodoxin reductase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
2007-12-08 Added SYNONYM adrenodoxin-type ferredoxin reductase activity
2007-12-08 Added SYNONYM NADPH:adrenodoxin oxidoreductase activity
2007-12-08 Added SYNONYM adrenodoxin reductase activity
2002-11-27 Updated DEFINITION Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+.
2001-08-06 Added DEFINITION An animal flavoenzyme that transfers electrons from NADPH to oxidised adrenodoxin, first enzymatic step in the mitochondrial P450 monooxygenase system.

Relationships

Timestamp Action Category Detail
2008-06-30 Added RELATION is a GO:0016491 (oxidoreductase activity)
2008-06-30 Deleted RELATION is a GO:0009055 (electron carrier activity)
2008-04-01 Updated RELATION is a GO:0009055 (electron carrier activity)

Cross-references

Timestamp Action Category Detail
2016-05-25 Added XREF MetaCyc:RXN-13685
2016-05-25 Added XREF EC:1.18.1.6
2016-05-25 Deleted XREF EC:1.18.1.-
2003-11-05 Added XREF EC:1.18.1.-
2003-11-05 Deleted XREF EC:1.18.1.2
2001-03-30 Added XREF EC:1.18.1.2
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