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GO:0015012 heparan sulfate proteoglycan biosynthetic process

Term Information

ID GO:0015012
Name heparan sulfate proteoglycan biosynthetic process
Ontology Biological Process
Definition The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
GONUTS GO:0015012 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact heparan sulfate proteoglycan anabolism
exact heparan sulfate proteoglycan biosynthesis
exact heparan sulfate proteoglycan synthesis
exact heparan sulfate proteoglycan formation
exact heparan sulphate proteoglycan biosynthesis
exact heparan sulphate proteoglycan biosynthetic process
related heparin proteoglycan biosynthetic process

Cross-Ontology Relations

Relation Other Ontology ID Term
has_output CHEBI CHEBI:24499 heparan sulfate proteoglycan

Cross-references

Database ID
InterPro IPR027670
InterPro IPR027673
InterPro IPR027674
RESID AA0210

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0015012:
Relationship To GO:0015012 Child Term Child Term Name
Part of GO:0015013 heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide
Part of GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
Part of GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification
Regulates GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process
Positively regulates GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0015012. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0015012 based on the entire annotation set Co-occurrence statistics for GO:0015012 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-11-28 Added RELATION is a GO:0044711 (single-organism biosynthetic process)
2011-10-28 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2011-10-28 Added DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2008-06-03 Added SYNONYM heparin proteoglycan biosynthetic process
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2008-04-01 Updated RELATION is a GO:0030166 (proteoglycan biosynthetic process)
2008-04-01 Updated RELATION is a GO:0030201 (heparan sulfate proteoglycan metabolic process)
2008-04-01 Updated RELATION is a GO:0044272 (sulfur compound biosynthetic process)
2007-08-09 Added SYNONYM heparan sulfate proteoglycan anabolism
2007-08-09 Added SYNONYM heparan sulfate proteoglycan biosynthesis
2007-08-09 Added SYNONYM heparan sulfate proteoglycan formation
2007-08-09 Added SYNONYM heparan sulfate proteoglycan synthesis
2007-08-09 Added SYNONYM heparan sulphate proteoglycan biosynthesis
2007-08-09 Added SYNONYM heparan sulphate proteoglycan biosynthetic process
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan biosynthesis
2007-08-09 Deleted SYNONYM heparan sulphate proteoglycan biosynthetic process
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan anabolism
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan formation
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan synthesis
2007-08-09 Deleted SYNONYM heparan sulphate proteoglycan biosynthesis
2007-01-15 Updated TERM heparan sulfate proteoglycan biosynthetic process
2007-01-15 Added SYNONYM heparan sulfate proteoglycan biosynthesis
2007-01-15 Added SYNONYM heparan sulphate proteoglycan biosynthetic process
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2005-08-10 Added SYNONYM heparan sulfate proteoglycan anabolism
2005-08-10 Added SYNONYM heparan sulfate proteoglycan formation
2005-08-10 Added SYNONYM heparan sulfate proteoglycan synthesis
2005-02-24 Added XREF RESID:AA0210
2004-04-19 Added SYNONYM heparan sulphate proteoglycan biosynthesis
2004-04-16 Deleted SYNONYM heparan sulphate proteoglycan biosynthesis
2003-11-13 Added SYNONYM heparan sulphate proteoglycan biosynthesis
2003-10-07 Updated DEFINITION The formation from simpler components of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2003-04-24 Updated DEFINITION The formation from simpler components of the heparan sulfate, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2002-11-27 Added DEFINITION The formation from simpler components of the heparan sulfate, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and non-sulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2002-02-06 Updated TERM heparan sulfate proteoglycan biosynthesis
2001-09-01 Updated TERM heparan sulfate proteoglycan biosynthesis
2001-08-24 Updated TERM heparan sulfate biosynthesis
2001-04-03 Updated TERM heparin sulfate biosynthesis
2001-03-30 Added TERM heparin sulfate biosynthesis

Term

Timestamp Action Category Detail
2007-01-15 Updated TERM heparan sulfate proteoglycan biosynthetic process
2002-02-06 Updated TERM heparan sulfate proteoglycan biosynthesis
2001-09-01 Updated TERM heparan sulfate proteoglycan biosynthesis
2001-08-24 Updated TERM heparan sulfate biosynthesis
2001-04-03 Updated TERM heparin sulfate biosynthesis
2001-03-30 Added TERM heparin sulfate biosynthesis

Definition/synonyms

Timestamp Action Category Detail
2011-10-28 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2011-10-28 Added DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2008-06-03 Added SYNONYM heparin proteoglycan biosynthetic process
2008-05-13 Added DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2008-05-12 Deleted DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2007-08-09 Added SYNONYM heparan sulfate proteoglycan anabolism
2007-08-09 Added SYNONYM heparan sulfate proteoglycan biosynthesis
2007-08-09 Added SYNONYM heparan sulfate proteoglycan formation
2007-08-09 Added SYNONYM heparan sulfate proteoglycan synthesis
2007-08-09 Added SYNONYM heparan sulphate proteoglycan biosynthesis
2007-08-09 Added SYNONYM heparan sulphate proteoglycan biosynthetic process
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan biosynthesis
2007-08-09 Deleted SYNONYM heparan sulphate proteoglycan biosynthetic process
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan anabolism
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan formation
2007-08-09 Deleted SYNONYM heparan sulfate proteoglycan synthesis
2007-08-09 Deleted SYNONYM heparan sulphate proteoglycan biosynthesis
2007-01-15 Added SYNONYM heparan sulfate proteoglycan biosynthesis
2007-01-15 Added SYNONYM heparan sulphate proteoglycan biosynthetic process
2006-05-04 Updated DEFINITION The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2005-08-10 Added SYNONYM heparan sulfate proteoglycan anabolism
2005-08-10 Added SYNONYM heparan sulfate proteoglycan formation
2005-08-10 Added SYNONYM heparan sulfate proteoglycan synthesis
2004-04-19 Added SYNONYM heparan sulphate proteoglycan biosynthesis
2004-04-16 Deleted SYNONYM heparan sulphate proteoglycan biosynthesis
2003-11-13 Added SYNONYM heparan sulphate proteoglycan biosynthesis
2003-10-07 Updated DEFINITION The formation from simpler components of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2003-04-24 Updated DEFINITION The formation from simpler components of the heparan sulfate, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
2002-11-27 Added DEFINITION The formation from simpler components of the heparan sulfate, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and non-sulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.

Relationships

Timestamp Action Category Detail
2013-11-28 Added RELATION is a GO:0044711 (single-organism biosynthetic process)
2008-04-01 Updated RELATION is a GO:0030166 (proteoglycan biosynthetic process)
2008-04-01 Updated RELATION is a GO:0030201 (heparan sulfate proteoglycan metabolic process)
2008-04-01 Updated RELATION is a GO:0044272 (sulfur compound biosynthetic process)

Cross-references

Timestamp Action Category Detail
2005-02-24 Added XREF RESID:AA0210
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