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GO:0015012 heparan sulfate proteoglycan biosynthetic process

The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.

Term Information

ID GO:0015012
Name heparan sulfate proteoglycan biosynthetic process
Ontology Biological Process
Definition The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating (alpha1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues.
Comment

Synonyms

Type Synonym
exact heparan sulfate proteoglycan biosynthesis
exact heparan sulfate proteoglycan anabolism
exact heparan sulphate proteoglycan biosynthetic process
exact heparan sulphate proteoglycan biosynthesis
exact heparan sulfate proteoglycan synthesis
exact heparan sulfate proteoglycan formation
related heparin proteoglycan biosynthetic process

Cross-references associated with this term:

Database ID
RESID AA0210

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0043170 macromolecule metabolic process
GO:0043283 biopolymer metabolic process
GO:0044237 cellular metabolic process
GO:0006790 sulfur metabolic process
GO:0009059 macromolecule biosynthetic process
GO:0044260 cellular macromolecule metabolic process
GO:0044249 cellular biosynthetic process
GO:0043284 biopolymer biosynthetic process
GO:0009100 glycoprotein metabolic process
GO:0034960 cellular biopolymer metabolic process
GO:0044272 sulfur compound biosynthetic process
GO:0006029 proteoglycan metabolic process
GO:0034645 cellular macromolecule biosynthetic process
GO:0030201 heparan sulfate proteoglycan metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0034961 cellular biopolymer biosynthetic process
GO:0030166 proteoglycan biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0015013 heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide
P GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
P GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification
R GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process
PR GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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