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GO:0014902 myotube differentiation

The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.

Term Information

ID GO:0014902
Name myotube differentiation
Ontology Biological Process
Definition The process whereby a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
Comment

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Ancestor Chart

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Ancestor Table

Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0032502 developmental process
GO:0032501 multicellular organismal process
GO:0048856 anatomical structure development
GO:0007275 multicellular organismal development
GO:0048869 cellular developmental process
GO:0030154 cell differentiation
GO:0042692 muscle cell differentiation
GO:0048731 system development
GO:0048468 cell development
GO:0048513 organ development
GO:0007517 muscle organ development
GO:0009888 tissue development
GO:0060538 skeletal muscle organ development
GO:0060537 muscle tissue development
GO:0014706 striated muscle tissue development
GO:0007519 skeletal muscle tissue development
GO:0048747 muscle fiber development
GO:0048741 skeletal muscle fiber development
GO:0014902 myotube differentiation

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
P GO:0007520 myoblast fusion
R GO:0010830 regulation of myotube differentiation
PR GO:0010831 positive regulation of myotube differentiation
NR GO:0010832 negative regulation of myotube differentiation
P GO:0014904 myotube cell development
I GO:0014908 myotube differentiation involved in skeletal muscle regeneration

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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