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GO:0014065 phosphatidylinositol 3-kinase signaling

Term Information

ID GO:0014065
Name phosphatidylinositol 3-kinase signaling
Ontology Biological Process
Definition A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
PMID:22525052
GONUTS GO:0014065 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related phosphatidylinositol 3-kinase cascade
exact phosphoinositide 3-kinase cascade
exact PI 3-kinase cascade
exact PI3K cascade
exact phosphatidylinositol 3-kinase signal transduction
exact PI3K signaling
exact PI3K signal transduction

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
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Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Cross-references

Database ID
InterPro IPR026722
InterPro IPR026723

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0023043 signaling via lipid mediator CONSIDER GO:0014065

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0014065:
Relationship To GO:0014065 Child Term Child Term Name
Regulates GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
Negatively regulates GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
Positively regulates GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0014065. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0014065 based on the entire annotation set Co-occurrence statistics for GO:0014065 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-12-14 Added SYNONYM PI3K signal transduction
2013-12-14 Added SYNONYM phosphatidylinositol 3-kinase signal transduction
2013-12-14 Added SYNONYM PI3K signaling
2013-12-14 Added DEFINITION A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2013-12-14 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2013-12-07 Added SYNONYM phosphatidylinositol 3-kinase cascade
2013-12-07 Updated TERM phosphatidylinositol 3-kinase signaling
2013-12-07 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2013-12-07 Added DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2011-09-23 Added RELATION is a GO:0048015 (phosphatidylinositol-mediated signaling)
2011-09-23 Deleted RELATION is a GO:0035556 (intracellular signal transduction)
2011-09-11 Added RELATION has part GO:0038028 (insulin receptor signaling pathway via phosphatidylinositol 3-kinase)
2011-01-30 Updated TERM phosphatidylinositol 3-kinase cascade
2011-01-30 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2011-01-30 Added DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2011-01-30 Added SYNONYM phosphoinositide 3-kinase cascade
2010-05-16 Added RELATION is a GO:0035556 (intracellular signal transduction)
2010-05-16 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-25 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-25 Deleted RELATION is a GO:0007243 (intracellular protein kinase cascade)
2008-05-13 Added DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2008-05-12 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2008-04-01 Updated RELATION is a GO:0007243 (intracellular protein kinase cascade)
2007-08-09 Added SYNONYM PI 3-kinase cascade
2007-08-09 Added SYNONYM PI3K cascade
2007-08-09 Deleted SYNONYM PI 3-kinase cascade
2007-08-09 Deleted SYNONYM PI3K cascade
2006-03-30 Added SYNONYM PI 3-kinase cascade
2006-03-30 Added SYNONYM PI3K cascade
2006-03-30 Added TERM phosphoinositide 3-kinase cascade
2006-03-30 Added DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.

Term

Timestamp Action Category Detail
2013-12-07 Updated TERM phosphatidylinositol 3-kinase signaling
2011-01-30 Updated TERM phosphatidylinositol 3-kinase cascade
2006-03-30 Added TERM phosphoinositide 3-kinase cascade

Definition/synonyms

Timestamp Action Category Detail
2013-12-14 Added SYNONYM PI3K signal transduction
2013-12-14 Added SYNONYM phosphatidylinositol 3-kinase signal transduction
2013-12-14 Added SYNONYM PI3K signaling
2013-12-14 Added DEFINITION A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2013-12-14 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2013-12-07 Added SYNONYM phosphatidylinositol 3-kinase cascade
2013-12-07 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2013-12-07 Added DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2011-01-30 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2011-01-30 Added DEFINITION A series of reactions, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2011-01-30 Added SYNONYM phosphoinositide 3-kinase cascade
2008-05-13 Added DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2008-05-12 Deleted DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.
2007-08-09 Added SYNONYM PI 3-kinase cascade
2007-08-09 Added SYNONYM PI3K cascade
2007-08-09 Deleted SYNONYM PI 3-kinase cascade
2007-08-09 Deleted SYNONYM PI3K cascade
2006-03-30 Added SYNONYM PI 3-kinase cascade
2006-03-30 Added SYNONYM PI3K cascade
2006-03-30 Added DEFINITION A series of reactions, mediated by the intracellular phosphoinositide 3-kinase (PI3K). PI3K cascades lie downstream of many cell surface receptor linked signaling pathways and regulate numerous cellular functions.

Relationships

Timestamp Action Category Detail
2011-09-23 Added RELATION is a GO:0048015 (phosphatidylinositol-mediated signaling)
2011-09-23 Deleted RELATION is a GO:0035556 (intracellular signal transduction)
2011-09-11 Added RELATION has part GO:0038028 (insulin receptor signaling pathway via phosphatidylinositol 3-kinase)
2010-05-16 Added RELATION is a GO:0035556 (intracellular signal transduction)
2010-05-16 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-25 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2010-04-25 Deleted RELATION is a GO:0007243 (intracellular protein kinase cascade)
2008-04-01 Updated RELATION is a GO:0007243 (intracellular protein kinase cascade)
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