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GO:0012501 programmed cell death

Term Information

ID GO:0012501
Name programmed cell death
Ontology Biological Process
Definition A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
Comment Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children, which are descendants of GO:0034050 'host programmed cell death induced by symbiont'.
Secondary IDs GO:0016244
GONUTS GO:0012501 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow caspase-independent cell death
related caspase-independent apoptosis
related regulated cell death
exact PCD
narrow nonapoptotic programmed cell death
narrow non-apoptotic programmed cell death

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

Cross-references

Database ID
UniProtKB-KW Necrosis
Wikipedia Programmed_cell_death

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008220 necrosis CONSIDER GO:0012501

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0012501:
Relationship To GO:0012501 Child Term Child Term Name
Is a GO:0006915 apoptotic process
Is a GO:0048102 autophagic cell death
Is a GO:0070268 cornification
Is a GO:0070269 pyroptosis
Is a GO:0010623 developmental programmed cell death
Is a GO:0034050 host programmed cell death induced by symbiont
Regulates GO:0043067 regulation of programmed cell death
Positively regulates GO:0043068 positive regulation of programmed cell death
Negatively regulates GO:0043069 negative regulation of programmed cell death
Is a GO:0097468 programmed cell death in response to reactive oxygen species
Is a GO:0097300 programmed necrotic cell death
Part of GO:0005035 death receptor activity
Part of GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0012501. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0012501 based on the entire annotation set Co-occurrence statistics for GO:0012501 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2013-11-28 Added SYNONYM caspase-independent cell death
2013-11-28 Added SYNONYM caspase-independent apoptosis
2013-03-10 Added SYNONYM regulated cell death
2011-11-26 Deleted DEFINITION Cell death resulting from activation of endogenous cellular processes.
2011-11-26 Added DEFINITION A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
2011-11-24 Added SYNONYM PCD
2009-03-29 Added XREF Wikipedia:Programmed_cell_death
2009-03-13 Deleted SYNONYM type II programmed cell death
2009-02-05 Deleted SYNONYM necrosis
2009-02-05 Added SYNONYM non-apoptotic programmed cell death
2009-02-05 Added SYNONYM nonapoptotic programmed cell death
2009-02-05 Added SYNONYM type II programmed cell death
2009-02-05 Added SECONDARY GO:0016244 (non-apoptotic programmed cell death)
2009-02-01 Deleted SECONDARY GO:0016244 (non-apoptotic programmed cell death)
2009-02-01 Added SYNONYM necrosis
2009-02-01 Deleted SYNONYM non-apoptotic programmed cell death
2009-02-01 Deleted SYNONYM nonapoptotic programmed cell death
2009-02-01 Deleted SYNONYM type II programmed cell death
2009-01-31 Added SYNONYM non-apoptotic programmed cell death
2009-01-31 Added SYNONYM nonapoptotic programmed cell death
2009-01-31 Added SYNONYM type II programmed cell death
2009-01-31 Deleted SYNONYM necrosis
2009-01-31 Added SECONDARY GO:0016244 (non-apoptotic programmed cell death)
2008-05-13 Added DEFINITION Cell death resulting from activation of endogenous cellular processes.
2008-05-12 Deleted DEFINITION Cell death resulting from activation of endogenous cellular processes.
2008-04-01 Updated RELATION is a GO:0008219 (cell death)
2007-08-09 Added SYNONYM necrosis
2007-08-09 Deleted SYNONYM necrosis
2005-08-10 Added SYNONYM necrosis
2002-11-27 Added DEFINITION Cell death resulting from activation of endogenous cellular processes.
2002-03-01 Added TERM programmed cell death
2002-02-27 Deleted TERM programmed cell death
2002-02-27 Added TERM programmed cell death

Term

Timestamp Action Category Detail
2002-03-01 Added TERM programmed cell death
2002-02-27 Deleted TERM programmed cell death
2002-02-27 Added TERM programmed cell death

Definition/synonyms

Timestamp Action Category Detail
2013-11-28 Added SYNONYM caspase-independent cell death
2013-11-28 Added SYNONYM caspase-independent apoptosis
2013-03-10 Added SYNONYM regulated cell death
2011-11-26 Deleted DEFINITION Cell death resulting from activation of endogenous cellular processes.
2011-11-26 Added DEFINITION A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
2011-11-24 Added SYNONYM PCD
2009-03-13 Deleted SYNONYM type II programmed cell death
2009-02-05 Deleted SYNONYM necrosis
2009-02-05 Added SYNONYM non-apoptotic programmed cell death
2009-02-05 Added SYNONYM nonapoptotic programmed cell death
2009-02-05 Added SYNONYM type II programmed cell death
2009-02-01 Added SYNONYM necrosis
2009-02-01 Deleted SYNONYM non-apoptotic programmed cell death
2009-02-01 Deleted SYNONYM nonapoptotic programmed cell death
2009-02-01 Deleted SYNONYM type II programmed cell death
2009-01-31 Added SYNONYM non-apoptotic programmed cell death
2009-01-31 Added SYNONYM nonapoptotic programmed cell death
2009-01-31 Added SYNONYM type II programmed cell death
2009-01-31 Deleted SYNONYM necrosis
2008-05-13 Added DEFINITION Cell death resulting from activation of endogenous cellular processes.
2008-05-12 Deleted DEFINITION Cell death resulting from activation of endogenous cellular processes.
2007-08-09 Added SYNONYM necrosis
2007-08-09 Deleted SYNONYM necrosis
2005-08-10 Added SYNONYM necrosis
2002-11-27 Added DEFINITION Cell death resulting from activation of endogenous cellular processes.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008219 (cell death)

Cross-references

Timestamp Action Category Detail
2009-03-29 Added XREF Wikipedia:Programmed_cell_death

Other

Timestamp Action Category Detail
2009-02-05 Added SECONDARY GO:0016244 (non-apoptotic programmed cell death)
2009-02-01 Deleted SECONDARY GO:0016244 (non-apoptotic programmed cell death)
2009-01-31 Added SECONDARY GO:0016244 (non-apoptotic programmed cell death)
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