spacer

GO:0010629 negative regulation of gene expression

Term Information

ID GO:0010629
Name negative regulation of gene expression
Ontology Biological Process
Definition Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
GONUTS GO:0010629 Wiki Page

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0010629:
Relationship To GO:0010629 Child Term Child Term Name
Is a GO:1901312 negative regulation of gene expression involved in extracellular matrix organization
Is a GO:0016458 gene silencing
Is a GO:0045814 negative regulation of gene expression, epigenetic
Is a GO:0045871 negative regulation of rhodopsin gene expression
Is a GO:0036208 negative regulation of histone gene expression
Is a GO:0045892 negative regulation of transcription, DNA-templated
Is a GO:0039657 suppression by virus of host gene expression

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0010629. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0010629 based on the entire annotation set Co-occurrence statistics for GO:0010629 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-11-10 Added RELATION is a GO:0010605 (negative regulation of macromolecule metabolic process)
2008-11-10 Deleted RELATION is a GO:0048523 (negative regulation of cellular process)
2008-10-21 Added RELATION is a GO:0048523 (negative regulation of cellular process)
2008-10-11 Added RELATION negatively regulates GO:0010467 (gene expression)
2008-07-18 Added TERM negative regulation of gene expression
2008-07-18 Added DEFINITION Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.
2008-07-18 Added RELATION is a GO:0010468 (regulation of gene expression)

Term

Timestamp Action Category Detail
2008-07-18 Added TERM negative regulation of gene expression

Definition/synonyms

Timestamp Action Category Detail
2008-07-18 Added DEFINITION Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.

Relationships

Timestamp Action Category Detail
2008-11-10 Added RELATION is a GO:0010605 (negative regulation of macromolecule metabolic process)
2008-11-10 Deleted RELATION is a GO:0048523 (negative regulation of cellular process)
2008-10-21 Added RELATION is a GO:0048523 (negative regulation of cellular process)
2008-10-11 Added RELATION negatively regulates GO:0010467 (gene expression)
2008-07-18 Added RELATION is a GO:0010468 (regulation of gene expression)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
11ms