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GO:0009968 negative regulation of signal transductionAny process that stops, prevents or reduces the frequency, rate or extent of signal transduction.
Term Information
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ID
| Type | Synonym |
| exact | down regulation of signal transduction |
| exact | down-regulation of signal transduction |
| exact | downregulation of signal transduction |
| narrow | inhibition of signal transduction |
Cross-references associated with this term:
| Database | ID |
| INTERPRO | IPR012918 |
Web service: term information
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Full details can be found on the QuickGO Web Services page.
Ancestor Chart
Visual display of a section of the GO directed acyclic graph (DAG) for a single GO term.
Terms in the GO are linked to parent (more general) terms and often to child (more specific) terms
by one or more 'relationships'
Chart
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
Ancestor Table
Alternative display of a section of the GO, providing a concise view of the relationships connecting GO terms
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0008150 biological_process | ||||||||||||
 | GO:0009987 cellular process | |||||||||||
|  | GO:0065007 biological regulation | ||||||||||
 | | | GO:0050789 regulation of biological process | |||||||||
 | |  | | GO:0007154 cell communication | ||||||||
 | | | | | GO:0048519 negative regulation of biological process | |||||||
 | | | | | | GO:0050794 regulation of cellular process | ||||||
| | | | | | | GO:0048523 negative regulation of cellular process | |||||
| | | | | | | | GO:0007165 signal transduction | ||||
| | | | | | | | | GO:0010646 regulation of cell communication | |||
| | | | | | | | | | GO:0009966 regulation of signal transduction | ||
| | | | | | | | | | | GO:0010648 negative regulation of cell communication | |
| | | | | | | | | | | | GO:0009968 negative regulation of signal transduction |
Relationship key
| Code | Relationship |
 | part of |
| is a |
| regulates |
 | +ve regulates |
| -ve regulates |
Child Terms
All direct descendants (child terms) available for this GO term:
| I |  GO:0051387 negative regulation of nerve growth factor receptor signaling pathway |
| I | GO:0051395 negative regulation of nerve growth factor receptor activity |
| I | GO:0001960 negative regulation of cytokine-mediated signaling pathway |
| I | GO:0031549 negative regulation of brain-derived neurotrophic factor receptor signaling pathway |
| I | GO:0032007 negative regulation of TOR signaling pathway |
| I | GO:0009788 negative regulation of abscisic acid mediated signaling pathway |
| I | GO:0009938 negative regulation of gibberellic acid mediated signaling pathway |
| I | GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway |
| I | GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway |
| I | GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway |
| I | GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway |
| I | GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway |
| I | GO:0045873 negative regulation of sevenless signaling pathway |
| I | GO:0046627 negative regulation of insulin receptor signaling pathway |
| I | GO:0048387 negative regulation of retinoic acid receptor signaling pathway |
| I | GO:0050849 negative regulation of calcium-mediated signaling |
| I | GO:0070298 negative regulation of two-component signal transduction system (phosphorelay) |
| I | GO:0070303 negative regulation of stress-activated protein kinase signaling pathway |
| I | GO:0070425 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| I | GO:0030178 negative regulation of Wnt receptor signaling pathway |
| I | GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway |
| I | GO:0045746 negative regulation of Notch signaling pathway |
| I | GO:0045751 negative regulation of Toll signaling pathway |
| I | GO:0045879 negative regulation of smoothened signaling pathway |
| I | GO:0031586 negative regulation of inositol-1,4,5-trisphosphate receptor activity |
| I | GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway |
| I | GO:0010741 negative regulation of protein kinase cascade |
| I | GO:0033144 negative regulation of steroid hormone receptor signaling pathway |
| I | GO:0060240 negative regulation of signal transduction involved in conjugation with cellular fusion |
| I | GO:0016060 metarhodopsin inactivation |
| I | GO:0022401 adaptation of signaling pathway |
| I | GO:0043951 negative regulation of cAMP-mediated signaling |
| I | GO:0070563 negative regulation of vitamin D receptor signaling pathway |
| I | GO:0075149 negative regulation of signal transduction in response to host |
| I | GO:0075210 negative regulation by symbiont of host cAMP-mediated signal transduction |
| I | GO:0034122 negative regulation of toll-like receptor signaling pathway |
| I | GO:0060400 negative regulation of growth hormone receptor signaling pathway |
| I | GO:0052004 negative regulation by symbiont of host salicylic acid-mediated defense response |
| I | GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator |
| I | GO:0010751 negative regulation of nitric oxide mediated signal transduction |
| I | GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway |
| I | GO:0010754 negative regulation of cGMP-mediated signaling |
| I | GO:0032926 negative regulation of activin receptor signaling pathway |
| I | GO:0050858 negative regulation of antigen receptor-mediated signaling pathway |
| I | GO:0051058 negative regulation of small GTPase mediated signal transduction |
| I | GO:0080037 negative regulation of cytokinin mediated signaling pathway |
| I | GO:0010930 negative regulation of auxin mediated signaling pathway |
Relationship key
| Code | Relationship |
| P | part of |
| I | is a |
Protein Annotation
Co-occurring Terms
Co-occurrence statistics
This display shows those GO terms which have been annotated to the same proteins as this term.
Terms may have been co-annotated either by electronic (IEA) or manual annotation methods.
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13ms
Stand-alone
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-24-04-03-40 |
Terminal