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GO:0009386 translational attenuation

Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.

Term Information

ID GO:0009386
Name translational attenuation
Ontology Biological Process
Definition Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.
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Ancestor Table

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0043170 macromolecule metabolic process
GO:0044238 primary metabolic process
GO:0050789 regulation of biological process
GO:0044237 cellular metabolic process
GO:0043283 biopolymer metabolic process
GO:0010467 gene expression
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
GO:0009059 macromolecule biosynthetic process
GO:0044260 cellular macromolecule metabolic process
GO:0044249 cellular biosynthetic process
GO:0019538 protein metabolic process
GO:0009889 regulation of biosynthetic process
GO:0080090 regulation of primary metabolic process
GO:0060255 regulation of macromolecule metabolic process
GO:0043284 biopolymer biosynthetic process
GO:0034960 cellular biopolymer metabolic process
GO:0031323 regulation of cellular metabolic process
GO:0010468 regulation of gene expression
GO:0010608 posttranscriptional regulation of gene expression
GO:0034645 cellular macromolecule biosynthetic process
GO:0044267 cellular protein metabolic process
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051246 regulation of protein metabolic process
GO:0031326 regulation of cellular biosynthetic process
GO:0034961 cellular biopolymer biosynthetic process
GO:0006412 translation
GO:0032268 regulation of cellular protein metabolic process
GO:0006417 regulation of translation
GO:0009386 translational attenuation

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

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Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-12-15-04-02-22
Terminal
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