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GO:0008897 holo-[acyl-carrier-protein] synthase activity

Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.

Term Information

ID GO:0008897
Name holo-[acyl-carrier-protein] synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form.
Comment

Synonyms

Type Synonym
exact phosphopantetheinyltransferase activity
exact alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity
exact CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity
exact CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity
related AcpS
exact holo-acyl-carrier-protein synthase activity
exact coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity
related acyl carrier protein synthase activity
exact acyl carrier protein holoprotein (holo-ACP) synthetase activity
exact PPTase activity
exact P-pant transferase activity
narrow L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity
related ACPS activity
exact 4'-phosphopantetheinyl transferase activity
related holosynthase activity
related holo-ACP synthetase activity
related holo-ACP synthase activity
related acyl carrier protein synthetase activity
exact alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity
exact alpha-aminoadipate reductase phosphopantetheinyl transferase activity
narrow holo-[peptidyl-carrier protein] synthase activity
narrow holo-[acyl-carrier-protein] synthase activity
exact 4'-phosphopantetheinyltransferase activity

Cross-references associated with this term:

Database ID
INTERPRO IPR016614
MetaCyc HOLO-ACP-SYNTH-RXN
EC 2.7.8.7
INTERPRO IPR008278
INTERPRO IPR002582
INTERPRO IPR004568

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016780 phosphotransferase activity, for other substituted phosphate groups
GO:0008897 holo-[acyl-carrier-protein] synthase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

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Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

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