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GO:0008725 DNA-3-methyladenine glycosylase activity

Term Information

ID GO:0008725
Name DNA-3-methyladenine glycosylase activity
Ontology Molecular Function
Definition Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.
PMID:10872450 PMID:9224623
GONUTS GO:0008725 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact DNA-3-methyladenine glycosylase I activity
related deoxyribonucleate 3-methyladenine glycosidase I
broad alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
related 3-methyladenine DNA glycosylase I
exact DNA-3-methyladenine glycosidase I activity
related DNA glycosidase I activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.2.2.20
EC 3.2.2.21
InterPro IPR004597
InterPro IPR005019
MetaCyc 3.2.2.20-RXN
MetaCyc 3.2.2.21-RXN

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0043736 obsolete DNA-3-methyladenine glycosylase IV activity CONSIDER GO:0008725

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008725:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008725. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008725 based on the entire annotation set Co-occurrence statistics for GO:0008725 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-10-30 Added XREF EC:3.2.2.21
2011-10-30 Added XREF MetaCyc:3.2.2.21-RXN
2011-10-30 Added SYNONYM DNA-3-methyladenine glycosylase I activity
2011-10-30 Added RELATION is a GO:0043733 (DNA-3-methylbase glycosylase activity)
2011-10-30 Deleted RELATION is a GO:0003905 (alkylbase DNA N-glycosylase activity)
2011-10-30 Updated TERM DNA-3-methyladenine glycosylase activity
2011-10-30 Added DEFINITION Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.
2011-10-30 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2008-04-01 Updated RELATION is a GO:0003905 (alkylbase DNA N-glycosylase activity)
2007-11-08 Added SYNONYM 3-methyladenine DNA glycosylase I
2007-11-08 Added SYNONYM alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
2007-11-08 Added SYNONYM deoxyribonucleate 3-methyladenine glycosidase I
2007-09-06 Added SYNONYM DNA glycosidase I activity
2007-09-06 Added SYNONYM DNA-3-methyladenine glycosidase I activity
2003-10-27 Added XREF MetaCyc:3.2.2.20-RXN
2003-09-09 Updated TERM DNA-3-methyladenine glycosylase I activity
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2003-03-19 Updated TERM DNA 3-methyladenine glycosylase I activity
2002-11-27 Added DEFINITION Only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2002-05-17 Updated TERM DNA 3-methyladenine glycosylase I
2002-02-06 Updated TERM DNA-3-methyladenine glycosylase I
2001-04-03 Updated TERM DNA-3-methyladenine glycosylase I
2001-03-30 Added XREF EC:3.2.2.20
2001-03-30 Added TERM DNA-3-methyladenine glycosylase I

Term

Timestamp Action Category Detail
2011-10-30 Updated TERM DNA-3-methyladenine glycosylase activity
2003-09-09 Updated TERM DNA-3-methyladenine glycosylase I activity
2003-03-19 Updated TERM DNA 3-methyladenine glycosylase I activity
2002-05-17 Updated TERM DNA 3-methyladenine glycosylase I
2002-02-06 Updated TERM DNA-3-methyladenine glycosylase I
2001-04-03 Updated TERM DNA-3-methyladenine glycosylase I
2001-03-30 Added TERM DNA-3-methyladenine glycosylase I

Definition/synonyms

Timestamp Action Category Detail
2011-10-30 Added SYNONYM DNA-3-methyladenine glycosylase I activity
2011-10-30 Added DEFINITION Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.
2011-10-30 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2008-05-13 Added DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2008-05-12 Deleted DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2007-11-08 Added SYNONYM 3-methyladenine DNA glycosylase I
2007-11-08 Added SYNONYM alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)
2007-11-08 Added SYNONYM deoxyribonucleate 3-methyladenine glycosidase I
2007-09-06 Added SYNONYM DNA glycosidase I activity
2007-09-06 Added SYNONYM DNA-3-methyladenine glycosidase I activity
2003-03-26 Updated DEFINITION Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.
2002-11-27 Added DEFINITION Only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site.

Relationships

Timestamp Action Category Detail
2011-10-30 Added RELATION is a GO:0043733 (DNA-3-methylbase glycosylase activity)
2011-10-30 Deleted RELATION is a GO:0003905 (alkylbase DNA N-glycosylase activity)
2008-04-01 Updated RELATION is a GO:0003905 (alkylbase DNA N-glycosylase activity)

Cross-references

Timestamp Action Category Detail
2011-10-30 Added XREF EC:3.2.2.21
2011-10-30 Added XREF MetaCyc:3.2.2.21-RXN
2003-10-27 Added XREF MetaCyc:3.2.2.20-RXN
2001-03-30 Added XREF EC:3.2.2.20
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