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GO:0008705 methionine synthase activity

Term Information

ID GO:0008705
Name methionine synthase activity
Ontology Molecular Function
Definition Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
GONUTS GO:0008705 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity
exact 5-methyltetrahydrofolate--homocysteine transmethylase activity
exact 5-methyltetrahydrofolate--homocysteine S-methyltransferase activity
exact N(5)-methyltetrahydrofolate methyltransferase activity
exact N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity
exact N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity
exact 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
exact N-methyltetrahydrofolate:L-homocysteine methyltransferase activity
exact cobalamin-dependent methionine synthase activity
exact methionine synthase (cobalamin-dependent) activity
exact methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity
exact vitamin B12 methyltransferase activity
exact tetrahydrofolate methyltransferase activity
exact tetrahydropteroylglutamate methyltransferase activity
exact tetrahydropteroylglutamic methyltransferase activity
exact N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity
exact N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity
exact N5-methyltetrahydrofolate methyltransferase activity
exact 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity
exact B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity
related MetH

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 2.1.1.13
InterPro IPR003759
InterPro IPR004223
InterPro IPR011822
KEGG R00946
MetaCyc HOMOCYSMETB12-RXN
RHEA 11175

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008705:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Term Name
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Original GO ID
Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008705. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008705 based on the entire annotation set Co-occurrence statistics for GO:0008705 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
2010-10-11 Added DEFINITION Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
2010-10-11 Added XREF RHEA:11175
2010-10-11 Added XREF KEGG:R00946
2010-06-15 Added RELATION part of GO:0009086 (methionine biosynthetic process)
2010-06-14 Deleted RELATION part of GO:0009086 (methionine biosynthetic process)
2010-06-08 Added RELATION part of GO:0009086 (methionine biosynthetic process)
2008-05-13 Added DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
2008-04-01 Updated RELATION is a GO:0042084 (5-methyltetrahydrofolate-dependent methyltransferase activity)
2008-04-01 Updated RELATION is a GO:0008172 (S-methyltransferase activity)
2007-11-08 Added SYNONYM 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity
2007-11-08 Added SYNONYM B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity
2007-11-08 Added SYNONYM MetH
2007-11-08 Added SYNONYM N5-methyltetrahydrofolate methyltransferase activity
2007-11-08 Added SYNONYM N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity
2007-11-08 Added SYNONYM N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity
2007-10-13 Deleted SYNONYM methionine synthetase activity
2007-09-06 Added SYNONYM 5-methyltetrahydrofolate--homocysteine S-methyltransferase activity
2007-09-06 Added SYNONYM 5-methyltetrahydrofolate--homocysteine transmethylase activity
2007-09-06 Added SYNONYM B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity
2007-09-06 Added SYNONYM N(5)-methyltetrahydrofolate methyltransferase activity
2007-09-06 Added SYNONYM N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity
2007-09-06 Added SYNONYM N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity
2007-09-06 Added SYNONYM N-methyltetrahydrofolate:L-homocysteine methyltransferase activity
2007-09-06 Added SYNONYM cobalamin-dependent methionine synthase activity
2007-09-06 Added SYNONYM methionine synthase (cobalamin-dependent) activity
2007-09-06 Added SYNONYM methionine synthetase activity
2007-09-06 Added SYNONYM methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity
2007-09-06 Added SYNONYM tetrahydrofolate methyltransferase activity
2007-09-06 Added SYNONYM tetrahydropteroylglutamate methyltransferase activity
2007-09-06 Added SYNONYM tetrahydropteroylglutamic methyltransferase activity
2007-09-06 Added SYNONYM vitamin B12 methyltransferase activity
2007-08-09 Added SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2007-08-09 Deleted SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2004-04-19 Added SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2004-04-16 Deleted SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2003-10-27 Added SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2003-10-27 Added XREF MetaCyc:HOMOCYSMETB12-RXN
2003-09-13 Updated TERM methionine synthase activity
2003-03-19 Updated TERM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
2002-02-06 Updated TERM 5-methyltetrahydrofolate-homocysteine S-methyltransferase
2001-11-07 Updated TERM 5-methyltetrahydrofolate-homocysteine S-methyltransferase
2001-04-03 Updated TERM 5-methyltetrahydrofolate--homocysteine S-methyltransferase
2001-03-30 Added XREF EC:2.1.1.13
2001-03-30 Added TERM 5-methyltetrahydrofolate--homocysteine S-methyltransferase

Term

Timestamp Action Category Detail
2003-09-13 Updated TERM methionine synthase activity
2003-03-19 Updated TERM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2002-02-06 Updated TERM 5-methyltetrahydrofolate-homocysteine S-methyltransferase
2001-11-07 Updated TERM 5-methyltetrahydrofolate-homocysteine S-methyltransferase
2001-04-03 Updated TERM 5-methyltetrahydrofolate--homocysteine S-methyltransferase
2001-03-30 Added TERM 5-methyltetrahydrofolate--homocysteine S-methyltransferase

Definition/synonyms

Timestamp Action Category Detail
2010-10-11 Deleted DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
2010-10-11 Added DEFINITION Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
2008-05-13 Added DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.
2007-11-08 Added SYNONYM 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity
2007-11-08 Added SYNONYM B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity
2007-11-08 Added SYNONYM MetH
2007-11-08 Added SYNONYM N5-methyltetrahydrofolate methyltransferase activity
2007-11-08 Added SYNONYM N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity
2007-11-08 Added SYNONYM N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity
2007-10-13 Deleted SYNONYM methionine synthetase activity
2007-09-06 Added SYNONYM 5-methyltetrahydrofolate--homocysteine S-methyltransferase activity
2007-09-06 Added SYNONYM 5-methyltetrahydrofolate--homocysteine transmethylase activity
2007-09-06 Added SYNONYM B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity
2007-09-06 Added SYNONYM N(5)-methyltetrahydrofolate methyltransferase activity
2007-09-06 Added SYNONYM N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity
2007-09-06 Added SYNONYM N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity
2007-09-06 Added SYNONYM N-methyltetrahydrofolate:L-homocysteine methyltransferase activity
2007-09-06 Added SYNONYM cobalamin-dependent methionine synthase activity
2007-09-06 Added SYNONYM methionine synthase (cobalamin-dependent) activity
2007-09-06 Added SYNONYM methionine synthetase activity
2007-09-06 Added SYNONYM methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity
2007-09-06 Added SYNONYM tetrahydrofolate methyltransferase activity
2007-09-06 Added SYNONYM tetrahydropteroylglutamate methyltransferase activity
2007-09-06 Added SYNONYM tetrahydropteroylglutamic methyltransferase activity
2007-09-06 Added SYNONYM vitamin B12 methyltransferase activity
2007-08-09 Added SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2007-08-09 Deleted SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2004-04-19 Added SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2004-04-16 Deleted SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2003-10-27 Added SYNONYM 5-methyltetrahydrofolate-homocysteine S-methyltransferase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine.

Relationships

Timestamp Action Category Detail
2010-06-15 Added RELATION part of GO:0009086 (methionine biosynthetic process)
2010-06-14 Deleted RELATION part of GO:0009086 (methionine biosynthetic process)
2010-06-08 Added RELATION part of GO:0009086 (methionine biosynthetic process)
2008-04-01 Updated RELATION is a GO:0042084 (5-methyltetrahydrofolate-dependent methyltransferase activity)
2008-04-01 Updated RELATION is a GO:0008172 (S-methyltransferase activity)

Cross-references

Timestamp Action Category Detail
2010-10-11 Added XREF RHEA:11175
2010-10-11 Added XREF KEGG:R00946
2003-10-27 Added XREF MetaCyc:HOMOCYSMETB12-RXN
2001-03-30 Added XREF EC:2.1.1.13
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