spacer

GO:0008657 DNA topoisomerase (ATP-hydrolyzing) inhibitor activity

Term Information

ID GO:0008657
Name DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
Ontology Molecular Function
Definition Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
GONUTS GO:0008657 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact DNA gyrase inhibitor activity

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
InterPro IPR002712
InterPro IPR024911

Ancestor Chart

This chart is interactive; you can click on the term boxes and legend for more information.
Display options
Display
Key
GO IDs
Term box width
Term box height
Slim colours
Show children
Image size limit (in megapixels)
Note that setting the limit too high may result in images being generated slowly; it may even cause the browser to crash. The maximum limit is 20 megapixels.

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008657:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

Export

Display options

ID Mapping

QuickGO maps between different identifier types by using a combination of mapping files provided by the databases, and using identifier cross-references supplied by UniProtKB.

If more than one identifier type needs to be used to map all required sequences, drag the selected databases to change the order in which identifiers are found.

Filter

Select

Grouped by
Annotation count
Protein count
Both

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008657. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008657 based on the entire annotation set Co-occurrence statistics for GO:0008657 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2011-08-12 Added RELATION part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity)
2011-08-12 Added RELATION is a GO:0072586 (DNA topoisomerase (ATP-hydrolyzing) regulator activity)
2011-08-12 Added RELATION is a GO:0042030 (ATPase inhibitor activity)
2011-08-12 Added RELATION negatively regulates GO:0003918 (DNA topoisomerase type II (ATP-hydrolyzing) activity)
2011-08-12 Deleted RELATION is a GO:0004857 (enzyme inhibitor activity)
2009-01-29 Updated TERM DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
2009-01-29 Added SYNONYM DNA gyrase inhibitor activity
2009-01-29 Deleted DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2009-01-29 Added DEFINITION Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2008-04-01 Updated RELATION is a GO:0004857 (enzyme inhibitor activity)
2003-06-17 Added DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2003-03-19 Updated TERM DNA gyrase inhibitor activity
2002-02-06 Updated TERM DNA gyrase inhibitor
2001-04-03 Updated TERM DNA gyrase inhibitor
2001-03-30 Added TERM DNA gyrase inhibitor

Term

Timestamp Action Category Detail
2009-01-29 Updated TERM DNA topoisomerase (ATP-hydrolyzing) inhibitor activity
2003-03-19 Updated TERM DNA gyrase inhibitor activity
2002-02-06 Updated TERM DNA gyrase inhibitor
2001-04-03 Updated TERM DNA gyrase inhibitor
2001-03-30 Added TERM DNA gyrase inhibitor

Definition/synonyms

Timestamp Action Category Detail
2009-01-29 Added SYNONYM DNA gyrase inhibitor activity
2009-01-29 Deleted DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2009-01-29 Added DEFINITION Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.
2008-05-13 Added DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2008-05-12 Deleted DEFINITION Stops, prevents or reduces the activity of DNA gyrase.
2003-06-17 Added DEFINITION Stops, prevents or reduces the activity of DNA gyrase.

Relationships

Timestamp Action Category Detail
2011-08-12 Added RELATION part of GO:2000372 (negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity)
2011-08-12 Added RELATION is a GO:0072586 (DNA topoisomerase (ATP-hydrolyzing) regulator activity)
2011-08-12 Added RELATION is a GO:0042030 (ATPase inhibitor activity)
2011-08-12 Added RELATION negatively regulates GO:0003918 (DNA topoisomerase type II (ATP-hydrolyzing) activity)
2011-08-12 Deleted RELATION is a GO:0004857 (enzyme inhibitor activity)
2008-04-01 Updated RELATION is a GO:0004857 (enzyme inhibitor activity)
spacer
Please send comments, suggestions or bug reports to goa@ebi.ac.uk. Click here for details of how to cite UniProt-GOA and QuickGO.
17ms