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GO:0006915 apoptotic process

Term Information

ID GO:0006915
Name apoptotic process
Ontology Biological Process
Definition A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
PMID:18846107 PMID:21494263
Secondary IDs GO:0006917 GO:0008632
GONUTS GO:0006915 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related induction of apoptosis
narrow apoptosis
broad cell suicide
broad cellular suicide
exact apoptotic cell death
related commitment to apoptosis
narrow apoptosis signaling
related induction of apoptosis by p53
related apoptosis activator activity
narrow activation of apoptosis
narrow apoptotic program
narrow type I programmed cell death
related signaling (initiator) caspase activity
exact apoptotic programmed cell death
exact programmed cell death by apoptosis

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR002117
InterPro IPR003508
InterPro IPR008063
InterPro IPR008064
InterPro IPR008092
InterPro IPR009062
InterPro IPR015142
InterPro IPR015470
InterPro IPR015471
InterPro IPR015917
InterPro IPR019502
InterPro IPR022103
InterPro IPR024140
InterPro IPR024579
InterPro IPR026117
InterPro IPR026668
InterPro IPR026753
InterPro IPR027322
InterPro IPR027770
InterPro IPR028192
InterPro IPR028319
InterPro IPR028320
InterPro IPR028326
InterPro IPR028502
InterPro IPR028754
InterPro IPR030030
InterPro IPR030257
UniProtKB-KW Apoptosis
Wikipedia Apoptosis

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004200 signaling (initiator) caspase activity CONSIDER GO:0006915
GO:0004207 effector caspase activity CONSIDER GO:0006915
GO:0006918 induction of apoptosis by p53 CONSIDER GO:0006915
GO:0006920 commitment to apoptosis CONSIDER GO:0006915
GO:0016506 apoptosis activator activity REPLACEDBY GO:0006915

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0006915:
Relationship To GO:0006915 Child Term Child Term Name
Is a GO:0043276 anoikis
Regulates GO:0042981 regulation of apoptotic process
Positively regulates GO:0043065 positive regulation of apoptotic process
Negatively regulates GO:0043066 negative regulation of apoptotic process
Part of GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
Part of GO:0008637 apoptotic mitochondrial changes
Part of GO:0097190 apoptotic signaling pathway
Part of GO:0097194 execution phase of apoptosis
Is a GO:1902742 apoptotic process involved in development
Part of GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
Part of GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process
Part of GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
Part of GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Part of GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
Is a GO:0097285 cell-type specific apoptotic process
Part of GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
Part of GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
Part of GO:0016505 peptidase activator activity involved in apoptotic process

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
Database
Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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ID Mapping

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0006915. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0006915 based on the entire annotation set Co-occurrence statistics for GO:0006915 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-04-12 Deleted DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
2014-04-12 Added DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2013-09-06 Added SECONDARY GO:0006917 (induction of apoptosis)
2013-09-06 Added SYNONYM commitment to apoptosis
2013-09-06 Added SYNONYM induction of apoptosis
2013-09-06 Added SYNONYM activation of apoptosis
2013-09-06 Added SYNONYM apoptosis activator activity
2013-09-06 Added SYNONYM induction of apoptosis by p53
2013-09-06 Added SYNONYM apoptosis signaling
2012-12-06 Deleted DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former.
2012-12-06 Added DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
2011-11-24 Added SYNONYM apoptosis
2011-11-24 Added SYNONYM cell suicide
2011-11-24 Added SYNONYM cellular suicide
2011-11-24 Updated TERM apoptotic process
2011-11-24 Deleted DEFINITION A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
2011-11-24 Added DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former.
2009-03-21 Added SECONDARY GO:0008632 (apoptotic program)
2009-03-21 Deleted DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2009-03-21 Added DEFINITION A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
2009-03-21 Added SYNONYM apoptotic program
2009-03-13 Added SYNONYM apoptotic cell death
2009-03-02 Added XREF Wikipedia:Apoptosis
2009-02-05 Deleted DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2009-02-05 Added DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2009-02-01 Deleted DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2009-02-01 Added DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2009-01-31 Deleted DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2009-01-31 Added DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2008-05-13 Added DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2008-05-12 Deleted DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2008-04-01 Updated RELATION is a GO:0012501 (programmed cell death)
2007-09-26 Deleted SYNONYM effector caspase activity
2007-08-09 Added SYNONYM apoptotic programmed cell death
2007-08-09 Added SYNONYM effector caspase activity
2007-08-09 Added SYNONYM programmed cell death by apoptosis
2007-08-09 Added SYNONYM signaling (initiator) caspase activity
2007-08-09 Added SYNONYM type I programmed cell death
2007-08-09 Deleted SYNONYM apoptotic programmed cell death
2007-08-09 Deleted SYNONYM effector caspase activity
2007-08-09 Deleted SYNONYM programmed cell death by apoptosis
2007-08-09 Deleted SYNONYM signaling (initiator) caspase activity
2007-08-09 Deleted SYNONYM type I programmed cell death
2007-01-25 Added SYNONYM apoptotic programmed cell death
2006-01-31 Updated DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2005-11-03 Added SYNONYM programmed cell death by apoptosis
2005-08-10 Added SYNONYM effector caspase activity
2005-08-10 Added SYNONYM signaling (initiator) caspase activity
2004-04-19 Added SYNONYM type I programmed cell death
2004-04-16 Deleted SYNONYM type I programmed cell death
2003-07-10 Updated DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine.
2002-02-06 Updated TERM apoptosis
2001-08-06 Added DEFINITION The intracellular, controlled process characterized by condensation and subsequent fragmentation of the cell nucleus during which the plasma membrane remains intact. The process of apoptosis begins with external or internal signals which trigger, directly or indirectly, a cascade of caspases and results in death of the cell. Characteristics are membrane blebbing, DNA fragmentation and macrophage-mediate endocytosis.
2001-04-03 Updated TERM apoptosis
2001-03-30 Added SYNONYM type I programmed cell death
2001-03-30 Added TERM apoptosis

Term

Timestamp Action Category Detail
2011-11-24 Updated TERM apoptotic process
2002-02-06 Updated TERM apoptosis
2001-04-03 Updated TERM apoptosis
2001-03-30 Added TERM apoptosis

Definition/synonyms

Timestamp Action Category Detail
2014-04-12 Deleted DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
2014-04-12 Added DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
2013-09-06 Added SYNONYM commitment to apoptosis
2013-09-06 Added SYNONYM induction of apoptosis
2013-09-06 Added SYNONYM activation of apoptosis
2013-09-06 Added SYNONYM apoptosis activator activity
2013-09-06 Added SYNONYM induction of apoptosis by p53
2013-09-06 Added SYNONYM apoptosis signaling
2012-12-06 Deleted DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former.
2012-12-06 Added DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase, and an execution phase, which is triggered by the former.
2011-11-24 Added SYNONYM apoptosis
2011-11-24 Added SYNONYM cell suicide
2011-11-24 Added SYNONYM cellular suicide
2011-11-24 Deleted DEFINITION A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
2011-11-24 Added DEFINITION A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former.
2009-03-21 Deleted DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2009-03-21 Added DEFINITION A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
2009-03-21 Added SYNONYM apoptotic program
2009-03-13 Added SYNONYM apoptotic cell death
2009-02-05 Deleted DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2009-02-05 Added DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2009-02-01 Deleted DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2009-02-01 Added DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2009-01-31 Deleted DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2009-01-31 Added DEFINITION A form of programmed cell death characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), classically little or no ultrastructural modifications of cytoplasmic organelles, plasma membrane blebbing (but maintenance of its integrity until the final stages of the process) and engulfment by resident phagocytes. Apoptosis is usually induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death.
2008-05-13 Added DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2008-05-12 Deleted DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2007-09-26 Deleted SYNONYM effector caspase activity
2007-08-09 Added SYNONYM apoptotic programmed cell death
2007-08-09 Added SYNONYM effector caspase activity
2007-08-09 Added SYNONYM programmed cell death by apoptosis
2007-08-09 Added SYNONYM signaling (initiator) caspase activity
2007-08-09 Added SYNONYM type I programmed cell death
2007-08-09 Deleted SYNONYM apoptotic programmed cell death
2007-08-09 Deleted SYNONYM effector caspase activity
2007-08-09 Deleted SYNONYM programmed cell death by apoptosis
2007-08-09 Deleted SYNONYM signaling (initiator) caspase activity
2007-08-09 Deleted SYNONYM type I programmed cell death
2007-01-25 Added SYNONYM apoptotic programmed cell death
2006-01-31 Updated DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposure of phosphatidyl serine on the cell surface.
2005-11-03 Added SYNONYM programmed cell death by apoptosis
2005-08-10 Added SYNONYM effector caspase activity
2005-08-10 Added SYNONYM signaling (initiator) caspase activity
2004-04-19 Added SYNONYM type I programmed cell death
2004-04-16 Deleted SYNONYM type I programmed cell death
2003-07-10 Updated DEFINITION A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle the cell and result in cell death. Apoptosis begins internally with condensation and subsequent fragmentation of the cell nucleus (blebbing) while the plasma membrane remains intact. Other characteristics of apoptosis include DNA fragmentation and the exposition of phosphatidylserine.
2001-08-06 Added DEFINITION The intracellular, controlled process characterized by condensation and subsequent fragmentation of the cell nucleus during which the plasma membrane remains intact. The process of apoptosis begins with external or internal signals which trigger, directly or indirectly, a cascade of caspases and results in death of the cell. Characteristics are membrane blebbing, DNA fragmentation and macrophage-mediate endocytosis.
2001-03-30 Added SYNONYM type I programmed cell death

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0012501 (programmed cell death)

Cross-references

Timestamp Action Category Detail
2009-03-02 Added XREF Wikipedia:Apoptosis

Other

Timestamp Action Category Detail
2013-09-06 Added SECONDARY GO:0006917 (induction of apoptosis)
2009-03-21 Added SECONDARY GO:0008632 (apoptotic program)
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