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GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage

Term Information

ID GO:0008630
Name intrinsic apoptotic signaling pathway in response to DNA damage
Ontology Biological Process
Definition A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
GONUTS GO:0008630 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related DNA damage response, signal transduction resulting in induction of apoptosis

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

Cross-references

Database ID
InterPro IPR028424

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008630:
Relationship To GO:0008630 Child Term Child Term Name
Is a GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Regulates GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Negatively regulates GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Positively regulates GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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GO Identifier
GO Term Name
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Original GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008630. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008630 based on the entire annotation set Co-occurrence statistics for GO:0008630 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-12-06 Updated TERM intrinsic apoptotic signaling pathway in response to DNA damage
2012-11-09 Deleted DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2012-11-09 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
2012-09-28 Updated TERM intrinsic apoptotic signaling pathway in response to DNA damage response
2012-09-28 Added SYNONYM DNA damage response, signal transduction resulting in induction of apoptosis
2012-09-28 Added RELATION is a GO:0097193 (intrinsic apoptotic signaling pathway)
2012-09-28 Added RELATION is a GO:0006974 (cellular response to DNA damage stimulus)
2012-09-28 Deleted RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2012-09-28 Deleted RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2008-05-13 Added DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2008-05-12 Deleted DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2008-04-01 Updated RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2008-04-01 Updated RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2005-10-14 Updated DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2003-06-21 Updated TERM DNA damage response, signal transduction resulting in induction of apoptosis
2003-06-21 Updated DEFINITION A cascade of processes initiated by the perception of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2002-11-27 Added DEFINITION The activation, by DNA damage, of any of the steps required for cell death by apoptosis.
2002-02-06 Updated TERM induction of apoptosis by DNA damage
2001-04-03 Updated TERM induction of apoptosis by DNA damage
2001-03-30 Added TERM induction of apoptosis by DNA damage

Term

Timestamp Action Category Detail
2012-12-06 Updated TERM intrinsic apoptotic signaling pathway in response to DNA damage
2012-09-28 Updated TERM intrinsic apoptotic signaling pathway in response to DNA damage response
2003-06-21 Updated TERM DNA damage response, signal transduction resulting in induction of apoptosis
2002-02-06 Updated TERM induction of apoptosis by DNA damage
2001-04-03 Updated TERM induction of apoptosis by DNA damage
2001-03-30 Added TERM induction of apoptosis by DNA damage

Definition/synonyms

Timestamp Action Category Detail
2012-11-09 Deleted DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2012-11-09 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
2012-09-28 Added SYNONYM DNA damage response, signal transduction resulting in induction of apoptosis
2008-05-13 Added DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2008-05-12 Deleted DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2005-10-14 Updated DEFINITION A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2003-06-21 Updated DEFINITION A cascade of processes initiated by the perception of DNA damage and resulting in the induction of apoptosis (programmed cell death).
2002-11-27 Added DEFINITION The activation, by DNA damage, of any of the steps required for cell death by apoptosis.

Relationships

Timestamp Action Category Detail
2012-09-28 Added RELATION is a GO:0097193 (intrinsic apoptotic signaling pathway)
2012-09-28 Added RELATION is a GO:0006974 (cellular response to DNA damage stimulus)
2012-09-28 Deleted RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2012-09-28 Deleted RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2008-04-01 Updated RELATION is a GO:0008629 (induction of apoptosis by intracellular signals)
2008-04-01 Updated RELATION is a GO:0042770 (signal transduction in response to DNA damage)
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