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GO:0097193 intrinsic apoptotic signaling pathway

Term Information

ID GO:0097193
Name intrinsic apoptotic signaling pathway
Ontology Biological Process
Definition A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
PMID:11919192 PMID:17340152 PMID:18852119
Comment The signals that start intrinsic apoptosis may come from extracellular sources (e.g. oxidative stress, UV exposure), but the reception of the signal and thus the signaling pathway start inside the cell (as a result of DNA damage, redox imbalance, etc.). Examples are ZPR9 (ZNF622) and ASK1 (MAP3K5) (UniProt symbols Q969S3 and Q99683) in PMID:21771788. A diagram of the intrinsic apoptotic pathway including examples of molecular players can be found in Figure 2 in PMID:21760595.
Secondary IDs GO:0008629
GONUTS GO:0097193 Wiki Page
Acknowledgements This term was created by the GO Consortium with support from KRUK logo

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related induction of apoptosis by intracellular signals
narrow intrinsic apoptosis
exact intrinsic apoptotic signalling pathway
exact intrinsic apoptotic pathway
exact mitochondrial-mediated apoptotic pathway

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0097193:
Relationship To GO:0097193 Child Term Child Term Name
Is a GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Is a GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress
Is a GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
Is a GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
Is a GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Regulates GO:2001242 regulation of intrinsic apoptotic signaling pathway
Negatively regulates GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Positively regulates GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Is a GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Gene Product ID
Symbol
Qualifier
GO Identifier
GO Term Name
Aspect
Original GO ID
Original GO Term Name
Evidence
Reference
With
Taxon
Date
Assigned By
Product Form ID
Name
Synonym
Type
Taxon Name
Sequence

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0097193. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0097193 based on the entire annotation set Co-occurrence statistics for GO:0097193 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-09-29 Deleted RELATION is a GO:0006917 (induction of apoptosis)
2012-09-28 Added SECONDARY GO:0008629 (induction of apoptosis by intracellular signals)
2012-09-28 Added RELATION is a GO:0006917 (induction of apoptosis)
2012-09-28 Added SYNONYM induction of apoptosis by intracellular signals
2012-04-14 Added SYNONYM intrinsic apoptotic signalling pathway
2012-03-29 Added SYNONYM intrinsic apoptosis
2012-02-04 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
2012-02-04 Deleted DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, growth factor withdrawal, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
2011-11-26 Added TERM intrinsic apoptotic signaling pathway
2011-11-26 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, growth factor withdrawal, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
2011-11-26 Added SYNONYM mitochondrial-mediated apoptotic pathway
2011-11-26 Added SYNONYM intrinsic apoptotic pathway
2011-11-26 Added RELATION is a GO:0097190 (apoptotic signaling pathway)
2011-11-26 Added RELATION is a GO:0035556 (intracellular signal transduction)

Term

Timestamp Action Category Detail
2011-11-26 Added TERM intrinsic apoptotic signaling pathway

Definition/synonyms

Timestamp Action Category Detail
2012-09-28 Added SYNONYM induction of apoptosis by intracellular signals
2012-04-14 Added SYNONYM intrinsic apoptotic signalling pathway
2012-03-29 Added SYNONYM intrinsic apoptosis
2012-02-04 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
2012-02-04 Deleted DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, growth factor withdrawal, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
2011-11-26 Added DEFINITION A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, growth factor withdrawal, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
2011-11-26 Added SYNONYM mitochondrial-mediated apoptotic pathway
2011-11-26 Added SYNONYM intrinsic apoptotic pathway

Relationships

Timestamp Action Category Detail
2012-09-29 Deleted RELATION is a GO:0006917 (induction of apoptosis)
2012-09-28 Added RELATION is a GO:0006917 (induction of apoptosis)
2011-11-26 Added RELATION is a GO:0097190 (apoptotic signaling pathway)
2011-11-26 Added RELATION is a GO:0035556 (intracellular signal transduction)

Other

Timestamp Action Category Detail
2012-09-28 Added SECONDARY GO:0008629 (induction of apoptosis by intracellular signals)
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