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GO:0008626 granzyme-mediated apoptotic signaling pathway

Term Information

ID GO:0008626
Name granzyme-mediated apoptotic signaling pathway
Ontology Biological Process
Definition A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
PMID:17158907
GONUTS GO:0008626 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
related induction of apoptosis by granzyme
related apoptotic signaling pathway in response to granzyme

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating cell death and apoptosis using the new guidelinesLink

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO.
If you would like to be involved in discussions regarding this development activity, please email the GO Consortium.
Please note that it is still appropriate to use this term for curation or analysis purposes.
Ontology Development Project
signallingLink

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000490 GO:0006915 apoptotic process never_in_taxon 33090 Viridiplantae
More information on taxon constraints in GO is available here

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008626:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008626. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008626 based on the entire annotation set Co-occurrence statistics for GO:0008626 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2012-12-08 Added SYNONYM apoptotic signaling pathway in response to granzyme
2012-09-21 Deleted DEFINITION Any process induced by granzyme that directly activates any of the steps required for cell death by apoptosis. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
2012-09-21 Added DEFINITION A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
2012-09-21 Updated TERM granzyme-mediated apoptotic signaling pathway
2012-09-21 Added RELATION is a GO:0097190 (apoptotic signaling pathway)
2012-09-21 Deleted RELATION is a GO:0008624 (induction of apoptosis by extracellular signals)
2012-09-21 Added SYNONYM induction of apoptosis by granzyme
2010-10-17 Added DEFINITION Any process induced by granzyme that directly activates any of the steps required for cell death by apoptosis. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
2008-04-01 Updated RELATION is a GO:0008624 (induction of apoptosis by extracellular signals)
2002-02-06 Updated TERM induction of apoptosis by granzyme
2001-04-03 Updated TERM induction of apoptosis by granzyme
2001-03-30 Added TERM induction of apoptosis by granzyme

Term

Timestamp Action Category Detail
2012-09-21 Updated TERM granzyme-mediated apoptotic signaling pathway
2002-02-06 Updated TERM induction of apoptosis by granzyme
2001-04-03 Updated TERM induction of apoptosis by granzyme
2001-03-30 Added TERM induction of apoptosis by granzyme

Definition/synonyms

Timestamp Action Category Detail
2012-12-08 Added SYNONYM apoptotic signaling pathway in response to granzyme
2012-09-21 Deleted DEFINITION Any process induced by granzyme that directly activates any of the steps required for cell death by apoptosis. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
2012-09-21 Added DEFINITION A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.
2012-09-21 Added SYNONYM induction of apoptosis by granzyme
2010-10-17 Added DEFINITION Any process induced by granzyme that directly activates any of the steps required for cell death by apoptosis. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells.

Relationships

Timestamp Action Category Detail
2012-09-21 Added RELATION is a GO:0097190 (apoptotic signaling pathway)
2012-09-21 Deleted RELATION is a GO:0008624 (induction of apoptosis by extracellular signals)
2008-04-01 Updated RELATION is a GO:0008624 (induction of apoptosis by extracellular signals)
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