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GO:0008622 epsilon DNA polymerase complex

Term Information

ID GO:0008622
Name epsilon DNA polymerase complex
Ontology Cellular Component
Definition A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
PMID:15814431 PMID:9745046
GONUTS GO:0008622 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact DNA polymerase epsilon complex

Taxon Constraints

The use of this term should conform to the following taxon constraints:
Taxon Rule Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GOTAX:0000057 GO:0005623 cell only_in_taxon 131567 cellular organisms
GOTAX:0000059 GO:0005634 nucleus only_in_taxon 2759 Eukaryota
More information on taxon constraints in GO is available here

Protein complexes

Database ID Name
IntAct dpol-epsilon_human DNA polymerase epsilon heterotetramer
IntAct dpol-epsilon_yeast DNA polymerase epsilon heterotetramer
IntAct dpol-epsilon_schpo DNA polymerase epsilon heterotetramer

Cross-references

Database ID
InterPro IPR029703

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008622:
Term has no children

Protein Annotation

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GO Identifier
GO Term Name
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008622. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008622 based on the entire annotation set Co-occurrence statistics for GO:0008622 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2009-10-31 Added SYNONYM DNA polymerase epsilon complex
2008-05-13 Added DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2008-05-12 Deleted DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2008-04-01 Updated RELATION part of GO:0000109 (nucleotide-excision repair complex)
2008-04-01 Updated RELATION part of GO:0043601 (nuclear replisome)
2008-04-01 Updated RELATION is a GO:0042575 (DNA polymerase complex)
2008-04-01 Updated RELATION is a GO:0044454 (nuclear chromosome part)
2007-05-27 Updated DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2005-09-30 Updated DEFINITION A nuclear DNA polymerase with proofreading exonuclease activity. High processivity in the absence of PCNA. Also involved in nucleotide-excision repair and mismatch repair.
2002-06-12 Updated TERM epsilon DNA polymerase complex
2002-02-06 Updated TERM epsilon DNA polymerase
2001-08-06 Added DEFINITION A nuclear DNA polymerase with proofreading exonuclease activity. High processivity in the absence of PCNA. Also involved in nucleotide excision repair and mismatch repair.
2001-04-03 Updated TERM epsilon DNA polymerase
2001-03-30 Added TERM epsilon DNA polymerase

Term

Timestamp Action Category Detail
2002-06-12 Updated TERM epsilon DNA polymerase complex
2002-02-06 Updated TERM epsilon DNA polymerase
2001-04-03 Updated TERM epsilon DNA polymerase
2001-03-30 Added TERM epsilon DNA polymerase

Definition/synonyms

Timestamp Action Category Detail
2009-10-31 Added SYNONYM DNA polymerase epsilon complex
2008-05-13 Added DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2008-05-12 Deleted DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2007-05-27 Updated DEFINITION A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
2005-09-30 Updated DEFINITION A nuclear DNA polymerase with proofreading exonuclease activity. High processivity in the absence of PCNA. Also involved in nucleotide-excision repair and mismatch repair.
2001-08-06 Added DEFINITION A nuclear DNA polymerase with proofreading exonuclease activity. High processivity in the absence of PCNA. Also involved in nucleotide excision repair and mismatch repair.

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION part of GO:0000109 (nucleotide-excision repair complex)
2008-04-01 Updated RELATION part of GO:0043601 (nuclear replisome)
2008-04-01 Updated RELATION is a GO:0042575 (DNA polymerase complex)
2008-04-01 Updated RELATION is a GO:0044454 (nuclear chromosome part)
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