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GO:0008622 epsilon DNA polymerase complex

A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.

Term Information

ID GO:0008622
Name epsilon DNA polymerase complex
Ontology Cellular Component
Definition A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.
Comment

Synonyms

Type Synonym
exact DNA polymerase epsilon complex

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Ancestor Table

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GO:0005575 cellular_component
GO:0005623 cell
GO:0032991 macromolecular complex
GO:0043226 organelle
GO:0032993 protein-DNA complex
GO:0043228 non-membrane-bounded organelle
GO:0043227 membrane-bounded organelle
GO:0044464 cell part
GO:0043234 protein complex
GO:0044422 organelle part
GO:0005622 intracellular
GO:0044424 intracellular part
GO:0043229 intracellular organelle
GO:0042575 DNA polymerase complex
GO:0044446 intracellular organelle part
GO:0043232 intracellular non-membrane-bounded organelle
GO:0043231 intracellular membrane-bounded organelle
GO:0005634 nucleus
GO:0005694 chromosome
GO:0044427 chromosomal part
GO:0044428 nuclear part
GO:0005657 replication fork
GO:0000109 nucleotide-excision repair complex
GO:0030894 replisome
GO:0000228 nuclear chromosome
GO:0044454 nuclear chromosome part
GO:0043596 nuclear replication fork
GO:0043601 nuclear replisome
GO:0008622 epsilon DNA polymerase complex

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
Download limit
Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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16ms
Stand-alone
Hostnametomcat-7.ebi.ac.uk
Uptime16:38 12/10/2009
Data version2009-12-16-04-01-54
Terminal
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