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GO:0008612 peptidyl-lysine modification to peptidyl-hypusine

Term Information

ID GO:0008612
Name peptidyl-lysine modification to peptidyl-hypusine
Ontology Biological Process
Definition The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.
Secondary IDs GO:0046515
GONUTS GO:0008612 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact hypusine anabolism
exact protein hypusination
exact hypusine synthesis
exact hypusine formation
exact hypusine biosynthetic process from peptidyl-lysine
exact hypusine biosynthesis
exact hypusine biosynthetic process
exact hypusine synthesis from peptidyl-lysine
exact hypusine formation from peptidyl-lysine
exact hypusine anabolism from peptidyl-lysine

Cross-Ontology Relations

Relation Other Ontology ID Term
has_input CHEBI CHEBI:29967 L-lysine residue
has_output CHEBI CHEBI:64640 hypusine residue

Cross-references

Database ID
InterPro IPR001884
InterPro IPR002773
InterPro IPR027517
RESID AA0116
UniProtKB-KW Hypusine biosynthesis

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0004171 deoxyhypusine synthase activity REPLACEDBY GO:0008612

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008612:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008612. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008612 based on the entire annotation set Co-occurrence statistics for GO:0008612 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2014-05-18 Updated TERM peptidyl-lysine modification to peptidyl-hypusine
2014-05-18 Deleted DEFINITION The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2014-05-18 Added DEFINITION The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.
2014-05-18 Deleted RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2014-05-18 Deleted RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2014-05-18 Deleted RELATION is a GO:0046516 (hypusine metabolic process)
2012-11-15 Added RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2012-07-13 Added SYNONYM protein hypusination
2011-03-09 Added RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2010-10-15 Added DEFINITION The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2010-10-15 Deleted DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2008-05-13 Added DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2008-05-12 Deleted DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2008-04-01 Updated RELATION is a GO:0018205 (peptidyl-lysine modification)
2008-04-01 Updated RELATION is a GO:0046516 (hypusine metabolic process)
2008-03-01 Added SECONDARY GO:0046515 (hypusine biosynthetic process)
2008-03-01 Added SYNONYM hypusine anabolism
2008-03-01 Added SYNONYM hypusine biosynthesis
2008-03-01 Added SYNONYM hypusine biosynthetic process
2008-03-01 Added SYNONYM hypusine biosynthetic process from peptidyl-lysine
2008-03-01 Added SYNONYM hypusine formation
2008-03-01 Added SYNONYM hypusine synthesis
2008-03-01 Updated TERM peptidyl-lysine modification to hypusine
2007-08-09 Added SYNONYM hypusine anabolism from peptidyl-lysine
2007-08-09 Added SYNONYM hypusine formation from peptidyl-lysine
2007-08-09 Added SYNONYM hypusine synthesis from peptidyl-lysine
2007-08-09 Deleted SYNONYM hypusine anabolism from peptidyl-lysine
2007-08-09 Deleted SYNONYM hypusine formation from peptidyl-lysine
2007-08-09 Deleted SYNONYM hypusine synthesis from peptidyl-lysine
2007-01-15 Updated TERM hypusine biosynthetic process from peptidyl-lysine
2005-08-10 Added SYNONYM hypusine anabolism from peptidyl-lysine
2005-08-10 Added SYNONYM hypusine formation from peptidyl-lysine
2005-08-10 Added SYNONYM hypusine synthesis from peptidyl-lysine
2005-02-24 Added XREF RESID:AA0116
2003-04-24 Updated DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2002-11-27 Updated DEFINITION The post-translational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2002-10-12 Updated TERM hypusine biosynthesis from peptidyl-lysine
2002-08-09 Updated TERM hypusine biosynthesis, from peptidyl-lysine
2002-02-06 Updated TERM hypusine biosynthesis
2001-08-06 Added DEFINITION The biosynthesis of hypusine (N-epsilon[4-amino-2-hydroxybutyl]lysine], by post-translational modification of a lysine residue of eukaryotic translation initiation factor 5A.
2001-04-03 Updated TERM hypusine biosynthesis
2001-03-30 Added TERM hypusine biosynthesis

Term

Timestamp Action Category Detail
2014-05-18 Updated TERM peptidyl-lysine modification to peptidyl-hypusine
2008-03-01 Updated TERM peptidyl-lysine modification to hypusine
2007-01-15 Updated TERM hypusine biosynthetic process from peptidyl-lysine
2002-10-12 Updated TERM hypusine biosynthesis from peptidyl-lysine
2002-08-09 Updated TERM hypusine biosynthesis, from peptidyl-lysine
2002-02-06 Updated TERM hypusine biosynthesis
2001-04-03 Updated TERM hypusine biosynthesis
2001-03-30 Added TERM hypusine biosynthesis

Definition/synonyms

Timestamp Action Category Detail
2014-05-18 Deleted DEFINITION The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2014-05-18 Added DEFINITION The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine.
2012-07-13 Added SYNONYM protein hypusination
2010-10-15 Added DEFINITION The modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2010-10-15 Deleted DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2008-05-13 Added DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2008-05-12 Deleted DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2008-03-01 Added SYNONYM hypusine anabolism
2008-03-01 Added SYNONYM hypusine biosynthesis
2008-03-01 Added SYNONYM hypusine biosynthetic process
2008-03-01 Added SYNONYM hypusine biosynthetic process from peptidyl-lysine
2008-03-01 Added SYNONYM hypusine formation
2008-03-01 Added SYNONYM hypusine synthesis
2007-08-09 Added SYNONYM hypusine anabolism from peptidyl-lysine
2007-08-09 Added SYNONYM hypusine formation from peptidyl-lysine
2007-08-09 Added SYNONYM hypusine synthesis from peptidyl-lysine
2007-08-09 Deleted SYNONYM hypusine anabolism from peptidyl-lysine
2007-08-09 Deleted SYNONYM hypusine formation from peptidyl-lysine
2007-08-09 Deleted SYNONYM hypusine synthesis from peptidyl-lysine
2005-08-10 Added SYNONYM hypusine anabolism from peptidyl-lysine
2005-08-10 Added SYNONYM hypusine formation from peptidyl-lysine
2005-08-10 Added SYNONYM hypusine synthesis from peptidyl-lysine
2003-04-24 Updated DEFINITION The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2002-11-27 Updated DEFINITION The post-translational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine.
2001-08-06 Added DEFINITION The biosynthesis of hypusine (N-epsilon[4-amino-2-hydroxybutyl]lysine], by post-translational modification of a lysine residue of eukaryotic translation initiation factor 5A.

Relationships

Timestamp Action Category Detail
2014-05-18 Deleted RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2014-05-18 Deleted RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2014-05-18 Deleted RELATION is a GO:0046516 (hypusine metabolic process)
2012-11-15 Added RELATION is a GO:1901607 (alpha-amino acid biosynthetic process)
2011-03-09 Added RELATION is a GO:0042398 (cellular modified amino acid biosynthetic process)
2008-04-01 Updated RELATION is a GO:0018205 (peptidyl-lysine modification)
2008-04-01 Updated RELATION is a GO:0046516 (hypusine metabolic process)

Cross-references

Timestamp Action Category Detail
2005-02-24 Added XREF RESID:AA0116

Other

Timestamp Action Category Detail
2008-03-01 Added SECONDARY GO:0046515 (hypusine biosynthetic process)
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