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GO:0004221 ubiquitin thiolesterase activity

This term is obsolete.
This term was made obsolete because this molecular function does not exist.

Term Information

ID GO:0004221
Name ubiquitin thiolesterase activity
Ontology Molecular Function
Definition OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
Comment This term was made obsolete because this molecular function does not exist.
Secondary IDs GO:0008577
GONUTS GO:0004221 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact ubiquitin-C-terminal-thioester hydrolase activity
narrow ubiquitinyl hydrolase 1 activity
related ubiquitin C-terminal hydrolase activity
related ubiquitin carboxy-terminal hydrolase activity
exact ubiquitin carboxy-terminal esterase activity
exact ubiquitin thioesterase activity

Replaced by

This term is obsolete - try one of these terms:
Advice GO Identifier Ontology GO Term Name
Consider GO:0004843 Molecular Function ubiquitin-specific protease activity
Consider GO:0036459 Molecular Function ubiquitinyl hydrolase activity

Cross-references

Database ID
EC 3.1.2.15
KEGG R02418
MetaCyc UBIQUITIN-THIOLESTERASE-RXN

Replaces

This term can be used instead of these obsolete terms:
GO Identifier GO Term Name Reason
GO:0008581 ubiquitin-specific protease 5 activity REPLACEDBY GO:0004221

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004221:
Term has no children

Protein Annotation

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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0004221. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0004221 based on the entire annotation set Co-occurrence statistics for GO:0004221 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2015-01-08 Updated TERM ubiquitin thiolesterase activity
2015-01-08 Deleted DEFINITION Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
2015-01-08 Added DEFINITION OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
2015-01-08 Deleted RELATION is a GO:0036459 (ubiquitinyl hydrolase activity)
2015-01-08 Deleted RELATION is a GO:0016790 (thiolester hydrolase activity)
2015-01-08 Added OBSOLETION consider GO:0036459 (ubiquitinyl hydrolase activity)
2015-01-08 Added OBSOLETION consider GO:0004843 (ubiquitin-specific protease activity)
2013-12-21 Added RELATION is a GO:0036459 (ubiquitinyl hydrolase activity)
2013-11-29 Deleted DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2013-11-29 Added DEFINITION Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
2013-11-29 Added XREF KEGG:R02418
2008-11-21 Deleted RELATION is a GO:0004843 (ubiquitin-specific protease activity)
2008-11-21 Deleted SYNONYM ubiquitin C-terminal hydrolase activity
2008-11-21 Deleted SYNONYM isopeptidase T
2008-11-21 Deleted SYNONYM ubiquitin carboxy-terminal hydrolase activity
2008-11-21 Added SYNONYM ubiquitin C-terminal hydrolase activity
2008-11-21 Added SYNONYM ubiquitin carboxy-terminal hydrolase activity
2008-11-21 Deleted SYNONYM isopeptidase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2008-04-01 Updated RELATION is a GO:0016790 (thiolester hydrolase activity)
2008-04-01 Updated RELATION is a GO:0004843 (ubiquitin-specific protease activity)
2007-11-08 Added SYNONYM isopeptidase T
2007-11-08 Added SYNONYM isopeptidase activity
2007-11-08 Added SYNONYM ubiquitin-C-terminal-thioester hydrolase activity
2007-10-16 Deleted SYNONYM ubiquitin thiolesterase activity
2007-09-06 Added SYNONYM ubiquitin carboxy-terminal esterase activity
2007-09-06 Added SYNONYM ubiquitin carboxy-terminal hydrolase activity
2007-09-06 Added SYNONYM ubiquitin thioesterase activity
2007-08-09 Added SYNONYM ubiquitin C-terminal hydrolase activity
2007-08-09 Added SYNONYM ubiquitin thiolesterase activity
2007-08-09 Added SYNONYM ubiquitinyl hydrolase 1 activity
2007-08-09 Deleted SYNONYM ubiquitin C-terminal hydrolase activity
2007-08-09 Deleted SYNONYM ubiquitin thiolesterase activity
2007-08-09 Deleted SYNONYM ubiquitinyl hydrolase 1 activity
2005-07-04 Added SYNONYM ubiquitin thiolesterase activity
2005-07-04 Added SYNONYM ubiquitinyl hydrolase 1 activity
2005-07-04 Deleted SYNONYM ubiquitin thiolesterase
2005-07-04 Deleted SYNONYM ubiquitinyl hydrolase 1
2004-05-23 Updated DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2004-04-19 Added SYNONYM ubiquitin C-terminal hydrolase activity
2004-04-19 Added SYNONYM ubiquitin thiolesterase
2004-04-19 Added SYNONYM ubiquitinyl hydrolase 1
2004-04-16 Deleted SYNONYM ubiquitin C-terminal hydrolase activity
2004-04-16 Deleted SYNONYM ubiquitin thiolesterase
2004-04-16 Deleted SYNONYM ubiquitinyl hydrolase 1
2003-10-27 Added SYNONYM ubiquitin C-terminal hydrolase activity
2003-10-27 Added SYNONYM ubiquitin thiolesterase
2003-10-27 Added SYNONYM ubiquitinyl hydrolase 1
2003-10-27 Added XREF MetaCyc:UBIQUITIN-THIOLESTERASE-RXN
2003-09-09 Updated TERM ubiquitin thiolesterase activity
2003-08-21 Deleted SYNONYM ubiquitin thiolesterase
2003-08-21 Deleted SYNONYM ubiquitinyl hydrolase 1
2003-08-05 Updated DEFINITION Catalysis of the hydrolysis of esters formed between thiols and the C-terminal glycine residue of the polypeptide ubiquitin, and of AMP-ubiquitin.
2003-03-19 Updated TERM ubiquitin C-terminal hydrolase activity
2002-11-27 Updated DEFINITION The hydrolysis of esters formed between thiols and the C-terminal glycine residue of the polypeptide ubiquitin, and of AMP-ubiquitin.
2002-06-07 Added SECONDARY GO:0008577 (ubiquitinyl hydrolase 1)
2002-06-07 Added SYNONYM ubiquitinyl hydrolase 1
2002-02-06 Updated TERM ubiquitin C-terminal hydrolase
2002-01-08 Added SYNONYM ubiquitin thiolesterase
2002-01-08 Updated TERM ubiquitin C-terminal hydrolase
2001-08-06 Added DEFINITION An enzyme that acts on esters formed between thiols and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin.
2001-04-03 Updated TERM ubiquitin thiolesterase
2001-03-30 Added XREF EC:3.1.2.15
2001-03-30 Added TERM ubiquitin thiolesterase

Term

Timestamp Action Category Detail
2015-01-08 Updated TERM ubiquitin thiolesterase activity
2003-09-09 Updated TERM ubiquitin thiolesterase activity
2003-03-19 Updated TERM ubiquitin C-terminal hydrolase activity
2002-02-06 Updated TERM ubiquitin C-terminal hydrolase
2002-01-08 Updated TERM ubiquitin C-terminal hydrolase
2001-04-03 Updated TERM ubiquitin thiolesterase
2001-03-30 Added TERM ubiquitin thiolesterase

Obsoletions

Timestamp Action Category Detail
2015-01-08 Added OBSOLETION consider GO:0036459 (ubiquitinyl hydrolase activity)
2015-01-08 Added OBSOLETION consider GO:0004843 (ubiquitin-specific protease activity)

Definition/synonyms

Timestamp Action Category Detail
2015-01-08 Deleted DEFINITION Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
2015-01-08 Added DEFINITION OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
2013-11-29 Deleted DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2013-11-29 Added DEFINITION Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol.
2008-11-21 Deleted SYNONYM ubiquitin C-terminal hydrolase activity
2008-11-21 Deleted SYNONYM isopeptidase T
2008-11-21 Deleted SYNONYM ubiquitin carboxy-terminal hydrolase activity
2008-11-21 Added SYNONYM ubiquitin C-terminal hydrolase activity
2008-11-21 Added SYNONYM ubiquitin carboxy-terminal hydrolase activity
2008-11-21 Deleted SYNONYM isopeptidase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2007-11-08 Added SYNONYM isopeptidase T
2007-11-08 Added SYNONYM isopeptidase activity
2007-11-08 Added SYNONYM ubiquitin-C-terminal-thioester hydrolase activity
2007-10-16 Deleted SYNONYM ubiquitin thiolesterase activity
2007-09-06 Added SYNONYM ubiquitin carboxy-terminal esterase activity
2007-09-06 Added SYNONYM ubiquitin carboxy-terminal hydrolase activity
2007-09-06 Added SYNONYM ubiquitin thioesterase activity
2007-08-09 Added SYNONYM ubiquitin C-terminal hydrolase activity
2007-08-09 Added SYNONYM ubiquitin thiolesterase activity
2007-08-09 Added SYNONYM ubiquitinyl hydrolase 1 activity
2007-08-09 Deleted SYNONYM ubiquitin C-terminal hydrolase activity
2007-08-09 Deleted SYNONYM ubiquitin thiolesterase activity
2007-08-09 Deleted SYNONYM ubiquitinyl hydrolase 1 activity
2005-07-04 Added SYNONYM ubiquitin thiolesterase activity
2005-07-04 Added SYNONYM ubiquitinyl hydrolase 1 activity
2005-07-04 Deleted SYNONYM ubiquitin thiolesterase
2005-07-04 Deleted SYNONYM ubiquitinyl hydrolase 1
2004-05-23 Updated DEFINITION Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin.
2004-04-19 Added SYNONYM ubiquitin C-terminal hydrolase activity
2004-04-19 Added SYNONYM ubiquitin thiolesterase
2004-04-19 Added SYNONYM ubiquitinyl hydrolase 1
2004-04-16 Deleted SYNONYM ubiquitin C-terminal hydrolase activity
2004-04-16 Deleted SYNONYM ubiquitin thiolesterase
2004-04-16 Deleted SYNONYM ubiquitinyl hydrolase 1
2003-10-27 Added SYNONYM ubiquitin C-terminal hydrolase activity
2003-10-27 Added SYNONYM ubiquitin thiolesterase
2003-10-27 Added SYNONYM ubiquitinyl hydrolase 1
2003-08-21 Deleted SYNONYM ubiquitin thiolesterase
2003-08-21 Deleted SYNONYM ubiquitinyl hydrolase 1
2003-08-05 Updated DEFINITION Catalysis of the hydrolysis of esters formed between thiols and the C-terminal glycine residue of the polypeptide ubiquitin, and of AMP-ubiquitin.
2002-11-27 Updated DEFINITION The hydrolysis of esters formed between thiols and the C-terminal glycine residue of the polypeptide ubiquitin, and of AMP-ubiquitin.
2002-06-07 Added SYNONYM ubiquitinyl hydrolase 1
2002-01-08 Added SYNONYM ubiquitin thiolesterase
2001-08-06 Added DEFINITION An enzyme that acts on esters formed between thiols and the C-terminal glycine residue of the polypeptide ubiquitin. Also acts on AMP-ubiquitin.

Relationships

Timestamp Action Category Detail
2015-01-08 Deleted RELATION is a GO:0036459 (ubiquitinyl hydrolase activity)
2015-01-08 Deleted RELATION is a GO:0016790 (thiolester hydrolase activity)
2013-12-21 Added RELATION is a GO:0036459 (ubiquitinyl hydrolase activity)
2008-11-21 Deleted RELATION is a GO:0004843 (ubiquitin-specific protease activity)
2008-04-01 Updated RELATION is a GO:0016790 (thiolester hydrolase activity)
2008-04-01 Updated RELATION is a GO:0004843 (ubiquitin-specific protease activity)

Cross-references

Timestamp Action Category Detail
2013-11-29 Added XREF KEGG:R02418
2003-10-27 Added XREF MetaCyc:UBIQUITIN-THIOLESTERASE-RXN
2001-03-30 Added XREF EC:3.1.2.15

Other

Timestamp Action Category Detail
2002-06-07 Added SECONDARY GO:0008577 (ubiquitinyl hydrolase 1)
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