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GO:0008559 xenobiotic-transporting ATPase activity

Term Information

ID GO:0008559
Name xenobiotic-transporting ATPase activity
Ontology Molecular Function
Definition Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
Secondary IDs GO:0005226 GO:0008560
GONUTS GO:0008559 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
exact ATP phosphohydrolase (steroid-exporting)
exact steroid-transporting ATPase activity
related pleiotropic-drug-resistance protein
narrow xenobiotic ABC transporter
related MDR protein
related multidrug-resistance protein
related multidrug resistance exporter
related P-glycoprotein
related PDR protein
narrow steroid ABC transporter
exact ATP phosphohydrolase (xenobiotic-exporting)

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 3.6.3.44
InterPro IPR030244
MetaCyc 3.6.3.44-RXN

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008559:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008559. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008559 based on the entire annotation set Co-occurrence statistics for GO:0008559 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2010-04-15 Deleted RELATION is a GO:0015239 (multidrug transporter activity)
2010-04-15 Added RELATION is a GO:0015238 (drug transmembrane transporter activity)
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2008-04-01 Updated RELATION is a GO:0015239 (multidrug transporter activity)
2008-04-01 Updated RELATION is a GO:0042910 (xenobiotic transporter activity)
2008-04-01 Updated RELATION is a GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
2007-11-08 Added SYNONYM ATP phosphohydrolase (steroid-exporting)
2007-11-08 Added SYNONYM ATP phosphohydrolase (xenobiotic-exporting)
2007-11-08 Added SYNONYM MDR protein
2007-11-08 Added SYNONYM PDR protein
2007-11-08 Added SYNONYM pleiotropic-drug-resistance protein
2007-11-08 Deleted XREF MetaCyc:3.6.3.45-RXN
2007-11-08 Deleted XREF EC:3.6.3.45
2007-08-09 Added SYNONYM P-glycoprotein
2007-08-09 Added SYNONYM multidrug resistance exporter
2007-08-09 Added SYNONYM multidrug-resistance protein
2007-08-09 Added SYNONYM steroid ABC transporter
2007-08-09 Added SYNONYM steroid-transporting ATPase activity
2007-08-09 Added SYNONYM xenobiotic ABC transporter
2007-08-09 Deleted SYNONYM steroid ABC transporter
2007-08-09 Deleted SYNONYM steroid-transporting ATPase activity
2007-08-09 Deleted SYNONYM P-glycoprotein
2007-08-09 Deleted SYNONYM multidrug resistance exporter
2007-08-09 Deleted SYNONYM multidrug-resistance protein
2007-08-09 Deleted SYNONYM xenobiotic ABC transporter
2007-07-11 Deleted XREF TC:3.A.1.201.1
2007-06-27 Added XREF MetaCyc:3.6.3.45-RXN
2007-06-27 Added XREF EC:3.6.3.45
2007-06-27 Added SECONDARY GO:0008560 (steroid-transporting ATPase activity)
2007-06-27 Added SYNONYM steroid ABC transporter
2007-06-27 Added SYNONYM steroid-transporting ATPase activity
2005-06-12 Added SYNONYM xenobiotic ABC transporter
2004-04-19 Added SYNONYM P-glycoprotein
2004-04-19 Added SYNONYM multidrug resistance exporter
2004-04-19 Added SYNONYM multidrug-resistance protein
2004-04-05 Deleted SYNONYM P-glycoprotein
2004-04-05 Deleted SYNONYM multidrug resistance exporter
2004-04-05 Deleted SYNONYM multidrug-resistance protein
2003-10-27 Added SYNONYM P-glycoprotein
2003-10-27 Added SYNONYM multidrug resistance exporter
2003-10-27 Added SYNONYM multidrug-resistance protein
2003-10-27 Added XREF TC:3.A.1.201.1
2003-10-27 Added XREF MetaCyc:3.6.3.44-RXN
2003-08-21 Deleted XREF TC:3.A.1.201.1
2003-08-21 Deleted SYNONYM P-glycoprotein
2003-08-21 Deleted SYNONYM multidrug resistance exporter
2003-08-21 Deleted SYNONYM multidrug-resistance protein
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2003-03-19 Updated TERM xenobiotic-transporting ATPase activity
2002-11-27 Updated DEFINITION The export of drugs from cells by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. Show unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione conjugates with drugs. Some also show some 'flippase' (magnesium-ATPase, GO:0004012) activity.
2002-02-06 Updated TERM xenobiotic-transporting ATPase
2001-08-06 Added DEFINITION The export of drugs from cells by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. Show unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione conjugates with drugs. Some also show some 'flippase' (magnesium-ATPase, GO:0004012) activity.
2001-04-03 Updated TERM xenobiotic-transporting ATPase
2001-03-30 Added XREF TC:3.A.1.201.1
2001-03-30 Added XREF EC:3.6.3.44
2001-03-30 Added SYNONYM P-glycoprotein
2001-03-30 Added SYNONYM multidrug resistance exporter
2001-03-30 Added SYNONYM multidrug-resistance protein
2001-03-30 Added TERM xenobiotic-transporting ATPase

Term

Timestamp Action Category Detail
2003-03-19 Updated TERM xenobiotic-transporting ATPase activity
2002-02-06 Updated TERM xenobiotic-transporting ATPase
2001-04-03 Updated TERM xenobiotic-transporting ATPase
2001-03-30 Added TERM xenobiotic-transporting ATPase

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2007-11-08 Added SYNONYM ATP phosphohydrolase (steroid-exporting)
2007-11-08 Added SYNONYM ATP phosphohydrolase (xenobiotic-exporting)
2007-11-08 Added SYNONYM MDR protein
2007-11-08 Added SYNONYM PDR protein
2007-11-08 Added SYNONYM pleiotropic-drug-resistance protein
2007-08-09 Added SYNONYM P-glycoprotein
2007-08-09 Added SYNONYM multidrug resistance exporter
2007-08-09 Added SYNONYM multidrug-resistance protein
2007-08-09 Added SYNONYM steroid ABC transporter
2007-08-09 Added SYNONYM steroid-transporting ATPase activity
2007-08-09 Added SYNONYM xenobiotic ABC transporter
2007-08-09 Deleted SYNONYM steroid ABC transporter
2007-08-09 Deleted SYNONYM steroid-transporting ATPase activity
2007-08-09 Deleted SYNONYM P-glycoprotein
2007-08-09 Deleted SYNONYM multidrug resistance exporter
2007-08-09 Deleted SYNONYM multidrug-resistance protein
2007-08-09 Deleted SYNONYM xenobiotic ABC transporter
2007-06-27 Added SYNONYM steroid ABC transporter
2007-06-27 Added SYNONYM steroid-transporting ATPase activity
2005-06-12 Added SYNONYM xenobiotic ABC transporter
2004-04-19 Added SYNONYM P-glycoprotein
2004-04-19 Added SYNONYM multidrug resistance exporter
2004-04-19 Added SYNONYM multidrug-resistance protein
2004-04-05 Deleted SYNONYM P-glycoprotein
2004-04-05 Deleted SYNONYM multidrug resistance exporter
2004-04-05 Deleted SYNONYM multidrug-resistance protein
2003-10-27 Added SYNONYM P-glycoprotein
2003-10-27 Added SYNONYM multidrug resistance exporter
2003-10-27 Added SYNONYM multidrug-resistance protein
2003-08-21 Deleted SYNONYM P-glycoprotein
2003-08-21 Deleted SYNONYM multidrug resistance exporter
2003-08-21 Deleted SYNONYM multidrug-resistance protein
2003-03-26 Updated DEFINITION Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out).
2002-11-27 Updated DEFINITION The export of drugs from cells by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. Show unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione conjugates with drugs. Some also show some 'flippase' (magnesium-ATPase, GO:0004012) activity.
2001-08-06 Added DEFINITION The export of drugs from cells by an ABC-type (ATP-binding cassette-type) ATPase, characterised by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process. Show unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally. Several distinct enzymes may be present in a single eukaryotic cell. Many of them transport glutathione conjugates with drugs. Some also show some 'flippase' (magnesium-ATPase, GO:0004012) activity.
2001-03-30 Added SYNONYM P-glycoprotein
2001-03-30 Added SYNONYM multidrug resistance exporter
2001-03-30 Added SYNONYM multidrug-resistance protein

Relationships

Timestamp Action Category Detail
2010-04-15 Deleted RELATION is a GO:0015239 (multidrug transporter activity)
2010-04-15 Added RELATION is a GO:0015238 (drug transmembrane transporter activity)
2008-04-01 Updated RELATION is a GO:0015239 (multidrug transporter activity)
2008-04-01 Updated RELATION is a GO:0042910 (xenobiotic transporter activity)
2008-04-01 Updated RELATION is a GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)

Cross-references

Timestamp Action Category Detail
2007-11-08 Deleted XREF MetaCyc:3.6.3.45-RXN
2007-11-08 Deleted XREF EC:3.6.3.45
2007-07-11 Deleted XREF TC:3.A.1.201.1
2007-06-27 Added XREF MetaCyc:3.6.3.45-RXN
2007-06-27 Added XREF EC:3.6.3.45
2003-10-27 Added XREF TC:3.A.1.201.1
2003-10-27 Added XREF MetaCyc:3.6.3.44-RXN
2003-08-21 Deleted XREF TC:3.A.1.201.1
2001-03-30 Added XREF TC:3.A.1.201.1
2001-03-30 Added XREF EC:3.6.3.44

Other

Timestamp Action Category Detail
2007-06-27 Added SECONDARY GO:0008560 (steroid-transporting ATPase activity)
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