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GO:0008534 oxidized purine base lesion DNA N-glycosylase activityCatalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
Term Information
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| Type | Synonym |
| related | purine-specific oxidized base lesion DNA N-glycosylase activity |
| exact | formamidopyrimidine-DNA glycosylase activity |
| broad | bifunctional DNA glycosylase activity |
| exact | DNA-formamidopyrimidine glycosylase activity |
| exact | fapy-DNA glycosylase activity |
| broad | DNA glycosylase/AP-lyase activity |
| broad | 8-oxoguanine DNA glycosylase activity |
| exact | Fapy-DNA glycosylase activity |
| broad | DNA glycosylase/beta-lyase activity |
| exact | deoxyribonucleate glycosidase activity |
| related | Fpg protein |
| related | DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing] |
| exact | 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity |
| exact | 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity |
| Database | ID |
| INTERPRO | IPR012904 |
| INTERPRO | IPR004577 |
| INTERPRO | IPR000191 |
| MetaCyc | 3.2.2.23-RXN |
| EC | 3.2.2.23 |
All GO terms displayed in this graph can be clicked to display term definitions and child (descendent) terms.
All GO terms displayed in this chart can be right-clicked to display term definitions and child (descendent) terms.
| GO:0003674 molecular_function | ||||||||||
![]() | GO:0003824 catalytic activity | |||||||||
![]() | ![]() | GO:0016787 hydrolase activity | ||||||||
![]() | ![]() | ![]() | GO:0016829 lyase activity | |||||||
![]() | ![]() | ![]() | ![]() | GO:0016798 hydrolase activity, acting on glycosyl bonds | ||||||
![]() | ![]() | ![]() | ![]() | ![]() | GO:0016835 carbon-oxygen lyase activity | |||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds | ||||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity | |||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0019104 DNA N-glycosylase activity | ||
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0000702 oxidized base lesion DNA N-glycosylase activity | |
![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | ![]() | GO:0008534 oxidized purine base lesion DNA N-glycosylase activity |
| Code | Relationship |
![]() | part of |
![]() | is a |
![]() | regulates |
![]() | +ve regulates |
![]() | -ve regulates |
| I | GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| Code | Relationship |
| P | part of |
| I | is a |
| Hostname | tomcat-7.ebi.ac.uk |
| Uptime | 16:38 12/10/2009 |
| Data version | 2009-11-23-04-03-36 |