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GO:0008534 oxidized purine base lesion DNA N-glycosylase activity

Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.

Term Information

ID GO:0008534
Name oxidized purine base lesion DNA N-glycosylase activity
Ontology Molecular Function
Definition Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site.
Comment Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.

Synonyms

Type Synonym
related purine-specific oxidized base lesion DNA N-glycosylase activity
exact formamidopyrimidine-DNA glycosylase activity
broad bifunctional DNA glycosylase activity
exact DNA-formamidopyrimidine glycosylase activity
exact fapy-DNA glycosylase activity
broad DNA glycosylase/AP-lyase activity
broad 8-oxoguanine DNA glycosylase activity
exact Fapy-DNA glycosylase activity
broad DNA glycosylase/beta-lyase activity
exact deoxyribonucleate glycosidase activity
related Fpg protein
related DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]
exact 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity
exact 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity

Cross-references associated with this term:

Database ID
INTERPRO IPR012904
INTERPRO IPR004577
INTERPRO IPR000191
MetaCyc 3.2.2.23-RXN
EC 3.2.2.23

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Ancestor Chart

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Ancestor Table

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016835 carbon-oxygen lyase activity
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0000702 oxidized base lesion DNA N-glycosylase activity
GO:0008534 oxidized purine base lesion DNA N-glycosylase activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
I GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Relationship key

CodeRelationship
Ppart of
Iis a

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

Co-occurrence statistics

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IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP Statistics may take up to 1 minute to calculate
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