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GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity

Term Information

ID GO:0008386
Name cholesterol monooxygenase (side-chain-cleaving) activity
Ontology Molecular Function
Definition Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
GONUTS GO:0008386 Wiki Page

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope. Click on the icon for more details.
Type Synonym
narrow cytochrome p450(scc) activity
broad steroid 20-22-lyase activity
related cholesterol side-chain-cleaving enzyme activity
related cholesterol side-chain cleavage enzyme activity
exact cholesterol desmolase activity
exact cholesterol C(20-22) desmolase activity
exact cholesterol 20-22-desmolase activity
narrow cytochrome P-450(scc) activity
broad steroid 20-22 desmolase activity
narrow Cyp11a1
related C27-side chain cleavage enzyme
exact cholesterol C20-22 desmolase activity
exact cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
related cytochrome P-450scc
related cytochrome p450scc
exact desmolase, steroid 20-22
related enzymes, cholesterol side-chain-cleaving

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:
Annotation Guidelines
Annotating to catalytic activities using the IPI evidence codeLink
Describing enzyme functions that catalyse multi-stage reactionsLink

Cross-references

Database ID
EC 1.14.15.6
MetaCyc 1.14.15.6-RXN

Ancestor Chart

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Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0008386:
Term has no children

Protein Annotation

Displaying annotations FIRST to LAST of TOTAL Page size: Additional filters: Bookmarkable link
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Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated with GO:0008386. The terms are listed in descending order of number of times the term has been co-annotated.
The table on the left is calculated using both electronic and manual-evidenced annotations, while the table on the right is calculated using only manual-evidenced annotations.
Co-occurrence statistics for GO:0008386 based on the entire annotation set Co-occurrence statistics for GO:0008386 based on non-IEA annotations only

Change Log

All changes

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
2008-04-01 Updated RELATION is a GO:0016713 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)
2007-11-08 Added SYNONYM C27-side chain cleavage enzyme
2007-11-08 Added SYNONYM cholesterol C20-22 desmolase activity
2007-11-08 Added SYNONYM cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
2007-11-08 Added SYNONYM cytochrome P-450scc
2007-11-08 Added SYNONYM cytochrome p450scc
2007-11-08 Added SYNONYM desmolase, steroid 20-22
2007-11-08 Added SYNONYM enzymes, cholesterol side-chain-cleaving
2007-09-06 Deleted SYNONYM cholesterol desmolase
2007-09-06 Added SYNONYM cholesterol 20-22-desmolase activity
2007-09-06 Added SYNONYM cholesterol C(20-22) desmolase activity
2007-09-06 Added SYNONYM cholesterol desmolase activity
2007-09-06 Added SYNONYM cholesterol side-chain cleavage enzyme activity
2007-09-06 Added SYNONYM cholesterol side-chain-cleaving enzyme activity
2007-09-06 Added SYNONYM cytochrome P-450(scc) activity
2007-09-06 Added SYNONYM cytochrome p450(scc) activity
2007-09-06 Added SYNONYM steroid 20-22 desmolase activity
2007-09-06 Added SYNONYM steroid 20-22-lyase activity
2007-08-09 Added SYNONYM Cyp11a1
2007-08-09 Added SYNONYM cholesterol desmolase
2007-08-09 Deleted SYNONYM Cyp11a1
2007-08-09 Deleted SYNONYM cholesterol desmolase
2004-04-19 Added SYNONYM Cyp11a1
2004-04-19 Added SYNONYM cholesterol desmolase
2004-04-16 Deleted SYNONYM Cyp11a1
2004-04-16 Deleted SYNONYM cholesterol desmolase
2003-10-27 Added SYNONYM Cyp11a1
2003-10-27 Added SYNONYM cholesterol desmolase
2003-10-27 Added XREF MetaCyc:1.14.15.6-RXN
2003-09-09 Updated TERM cholesterol monooxygenase (side-chain-cleaving) activity
2003-08-18 Deleted SYNONYM cholesterol desmolase
2003-08-18 Deleted SYNONYM Cyp11a1
2003-03-19 Updated TERM cholesterol monooxygenase (side-chain cleaving) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
2002-02-06 Updated TERM cholesterol monooxygenase (side-chain cleaving)
2001-04-03 Updated TERM cholesterol monooxygenase (side-chain cleaving)
2001-03-30 Added XREF EC:1.14.15.6
2001-03-30 Added SYNONYM Cyp11a1
2001-03-30 Added SYNONYM cholesterol desmolase
2001-03-30 Added TERM cholesterol monooxygenase (side-chain cleaving)

Term

Timestamp Action Category Detail
2003-09-09 Updated TERM cholesterol monooxygenase (side-chain-cleaving) activity
2003-03-19 Updated TERM cholesterol monooxygenase (side-chain cleaving) activity
2002-02-06 Updated TERM cholesterol monooxygenase (side-chain cleaving)
2001-04-03 Updated TERM cholesterol monooxygenase (side-chain cleaving)
2001-03-30 Added TERM cholesterol monooxygenase (side-chain cleaving)

Definition/synonyms

Timestamp Action Category Detail
2008-05-13 Added DEFINITION Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
2007-11-08 Added SYNONYM C27-side chain cleavage enzyme
2007-11-08 Added SYNONYM cholesterol C20-22 desmolase activity
2007-11-08 Added SYNONYM cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
2007-11-08 Added SYNONYM cytochrome P-450scc
2007-11-08 Added SYNONYM cytochrome p450scc
2007-11-08 Added SYNONYM desmolase, steroid 20-22
2007-11-08 Added SYNONYM enzymes, cholesterol side-chain-cleaving
2007-09-06 Deleted SYNONYM cholesterol desmolase
2007-09-06 Added SYNONYM cholesterol 20-22-desmolase activity
2007-09-06 Added SYNONYM cholesterol C(20-22) desmolase activity
2007-09-06 Added SYNONYM cholesterol desmolase activity
2007-09-06 Added SYNONYM cholesterol side-chain cleavage enzyme activity
2007-09-06 Added SYNONYM cholesterol side-chain-cleaving enzyme activity
2007-09-06 Added SYNONYM cytochrome P-450(scc) activity
2007-09-06 Added SYNONYM cytochrome p450(scc) activity
2007-09-06 Added SYNONYM steroid 20-22 desmolase activity
2007-09-06 Added SYNONYM steroid 20-22-lyase activity
2007-08-09 Added SYNONYM Cyp11a1
2007-08-09 Added SYNONYM cholesterol desmolase
2007-08-09 Deleted SYNONYM Cyp11a1
2007-08-09 Deleted SYNONYM cholesterol desmolase
2004-04-19 Added SYNONYM Cyp11a1
2004-04-19 Added SYNONYM cholesterol desmolase
2004-04-16 Deleted SYNONYM Cyp11a1
2004-04-16 Deleted SYNONYM cholesterol desmolase
2003-10-27 Added SYNONYM Cyp11a1
2003-10-27 Added SYNONYM cholesterol desmolase
2003-08-18 Deleted SYNONYM cholesterol desmolase
2003-08-18 Deleted SYNONYM Cyp11a1
2002-11-27 Added DEFINITION Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
2001-03-30 Added SYNONYM Cyp11a1
2001-03-30 Added SYNONYM cholesterol desmolase

Relationships

Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016713 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)
2008-04-01 Updated RELATION is a GO:0008395 (steroid hydroxylase activity)

Cross-references

Timestamp Action Category Detail
2003-10-27 Added XREF MetaCyc:1.14.15.6-RXN
2001-03-30 Added XREF EC:1.14.15.6
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