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GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.

Term Information

ID GO:0008386
Name cholesterol monooxygenase (side-chain-cleaving) activity
Ontology Molecular Function
Definition Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.
Comment

Synonyms

Type Synonym
broad steroid 20-22-lyase activity
exact cholesterol 20-22-desmolase activity
exact cholesterol C(20-22) desmolase activity
exact cholesterol desmolase activity
related cholesterol side-chain cleavage enzyme activity
related cholesterol side-chain-cleaving enzyme activity
narrow cytochrome P-450(scc) activity
narrow cytochrome p450(scc) activity
broad steroid 20-22 desmolase activity
related C27-side chain cleavage enzyme
exact cholesterol C20-22 desmolase activity
exact cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
related cytochrome P-450scc
related cytochrome p450scc
exact desmolase, steroid 20-22
related enzymes, cholesterol side-chain-cleaving
narrow Cyp11a1

Cross-references associated with this term:

Database ID
MetaCyc 1.14.15.6-RXN
EC 1.14.15.6

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0004497 monooxygenase activity
GO:0008395 steroid hydroxylase activity
GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity

Relationship key

Code Relationship
part of
is a
regulates
+ve regulates
-ve regulates

Child Terms

All direct descendants (child terms) available for this GO term:
Term has no children

Protein Annotation

DB
ID
Qualifier colocalizes_with contributes_to NOT NOT|colocalizes_with NOT|contributes_to
GO Term
Reference
Evidence IMP IGI IPI IGC ISS IDA IEP IEA TAS NAS ND IC RCA ISA EXP
With
Taxonomy
From
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Format

Co-occurring Terms

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